Clinical trials · Massachusetts
Depression clinical trials in Massachusetts
We’re tracking 100 recruiting depression studies with a site in Massachusetts — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT07082998Recruiting
Heated yoga vs. sauna for depression
This study compares heated yoga with sauna sessions to see which helps reduce depression. You'll also use a mindfulness app. Both treatments are meant to boost mood and well-being.
Boston, MassachusettsAges 18–65 - NCT06968390Recruiting
Faster TMS for depression during pregnancy or after childbirth
This trial tests a faster form of TMS (brain stimulation) for people with depression who are pregnant (14-34 weeks) or within one year of giving birth. It aims to see if the treatment is safe and well-tolerated.
Boston, MassachusettsAges 18–55 - NCT07621237RecruitingPhase 2
TNX-102 SL for Major Depressive Disorder
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
Methuen, MassachusettsAges 18 years+ - NCT07161700Enrolling by invitationPhase 2
Long-term safety study of SPT-300 for major depression
This study is for people who finished the earlier BUOY-1 study of SPT-300 and want to continue treatment. It tests the long-term safety and tolerability of SPT-300 for major depressive disorder, with or without anxious distress.
Boston, MassachusettsAges 18–66 - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Boston, MassachusettsAges 18–65 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Watertown, MassachusettsAges 18–65 - NCT06289010Recruiting
Family therapy for childhood depression: brain study
This study tests whether a family-focused therapy can help children ages 7 to 12 with depression. It looks at how the brain changes during treatment using an MRI scan.
Boston, MassachusettsAges 7–12 - NCT05393622Recruiting
Brain stimulation trial for severe, treatment-resistant depression
This study tests an implanted form of brain stimulation for people with severe depression that has not improved with multiple medication trials. If you qualify, you would have brain scans and surgery planning, then follow a treatment-and-safety plan for several months.
Boston, MassachusettsAges 21–80 - NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT06878859Recruiting
Online program for depression and cannabis use
This study tests a digital (online) program designed to help people who struggle with both depression and cannabis use. If you're feeling down and also using cannabis more than you'd like, this program might help you manage both.
Boston, MassachusettsAges 18 years+ - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Boston, MassachusettsAges 18–75 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Boston, MassachusettsAges 18 years+ - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
Boston, MassachusettsAges 18–74 - NCT06238700Recruiting
Studying allopregnanolone for depression in midlife women
This trial tests whether allopregnanolone, a natural brain chemical, can help depression in women going through menopause. It compares the effects against a placebo to see if it improves mood symptoms.
Boston, MassachusettsAges 40–60 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Boston, MassachusettsAges 18 years+ - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Boston, MassachusettsAges 18–75 - NCT05921201Recruiting
RRE program to prevent depression in Chinese American teens
This trial tests an education and skills program (Relax, Reflect, and Empower, or RRE) designed to help prevent depression in Chinese American teens. It may help by teaching coping strategies before symptoms become more serious.
Boston, MassachusettsAges 14–18 - NCT07195721Recruiting
How special contact lenses affect mental health
This study looks at whether PROSE or scleral lenses can improve mental health in people with certain eye surface conditions. It may be a good fit if you have a dry eye or related disease and are considering these lenses.
Needham, MassachusettsAges Any age - NCT07655232Recruiting
Behavioral program for depression in nursing homes
This study tests a behavioral program designed to help skilled nursing facility residents with depression. The program aims to improve mood and quality of life.
Boston, MassachusettsAges 18 years+ - NCT06017622Recruiting
THC Levels in Young People with Cannabis Overdose in the ER
This study looks at the amount of THC (the active ingredient in cannabis) in the blood of children and teens who come to the emergency room with severe drowsiness or confusion after using cannabis. It will help doctors better understand how cannabis affects young people.
Worcester, MassachusettsAges Any age - NCT06597695RecruitingPhase 1/Phase 2
Ketamine group therapy for Spanish-speaking adults with depression
This trial tests whether ketamine-assisted group therapy can help Spanish-speaking Latinx adults with major depression. You would receive ketamine in a supportive group setting, with the goal of improving your mood and quality of life.
Chelsea, MassachusettsAges 18–64 - NCT03276793Recruiting
Brain connectivity study in people with depression
This study looks at brain “connectivity” (how different brain areas talk to each other) in people with depression. You may be able to join if you are already getting once-daily TMS to a specific brain area at Brigham and Women’s or Massachusetts General, and you can safely complete MRI scans.
Boston, MassachusettsAges 18 years+ - NCT06876129RecruitingPhase 1
Adding D-serine to TMS for depression
This trial tests whether adding a medication called D-serine to a brain stimulation treatment (TMS) helps improve depression. It’s for adults with major depression who are already getting TMS therapy.
Belmont, MassachusettsAges 18–80 - NCT06775379RecruitingPhase 3
Azetukalner vs. placebo for major depression
This trial tests an investigational medication called Azetukalner against a placebo to see if it helps reduce symptoms of major depressive disorder. You may qualify if you are currently in a depressive episode that started in adulthood and have not tried or failed only a few antidepressants.
Boston, MassachusettsAges 18–74
Depression trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting depression studies listed above.
- Massachusetts General Hospital · 7 studies
- Adams Clinical · 3 studies
- Beth Israel Deaconess Medical Center · 2 studies
- Brigham and Women's Hospital · 2 studies
- Seaport Investigator Site · 2 studies
- Vitalix Clinical · 2 studies
- ActivMed Practices and Research
- Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Massachusetts?
- Yes. We're currently tracking 100 recruiting depression studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.