Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07051200Recruiting
Support program for young adults after a mental health crisis
This study offers a program to support young adults who recently faced a mental health crisis. It aims to help you recover by providing inspiration, support, and empowerment after a hospital stay.
Dallas, TexasAges 18–27 - NCT07048574Recruiting
Mood and behavior in children with cystic fibrosis
This study looks at mood and behavior in children with cystic fibrosis (CF) under 12. By following children over time, researchers hope to better understand and help with depression, anxiety, and behavior challenges that may come up.
Orange, CaliforniaAges 1.5 years–11 years - NCT06979440Recruiting
Berberine for diabetes with depression
This trial tests if berberine, a natural compound, can improve both blood sugar and mood in people who have type 2 diabetes and major depression. It aims to understand how berberine works at a molecular level.
Nantong, JiangsuAges 18–65 - NCT07036757Recruiting
Healthy meal kits for better health
This study provides free healthy meal kits to adults with overweight and health concerns to see if they can improve blood sugar, blood pressure, and weight. It is for people 40 and older with low income who live in the Greater Lowell area.
Lowell, MassachusettsAges 40 years+ - NCT07039305Recruiting
Building physical strength after stroke
This study looks at whether a specific exercise program can help people with chronic stroke (more than 6 months ago) who still have some weakness in their leg. It aims to improve walking and overall physical ability.
Charleston, South CarolinaAges 18–80 - NCT06770517Recruiting
Exposure therapy for anxiety in older adults
This study tests whether exposure therapy helps older adults with anxiety. It focuses on people 60 and older who have conditions like generalized anxiety, panic disorder, agoraphobia, or social anxiety.
Nederland, NijmegenAges 65 years+ - NCT07032480Recruiting
Sleep, Neck Pain, and Depression Study
This study looks at how sleep problems, neck pain, and depression might be connected in healthy young adults. It aims to help understand these common issues better.
Istanbul, ÜsküdarAges 18–28 - NCT07025590Recruiting
Exercise to help lower antidepressants for heart patients
This trial tests whether adding a structured exercise program can help people with both depression/anxiety and heart disease slowly reduce their antidepressant medication. It may offer a way to lower medication use while improving heart and mental health.
Guangzhou, GuangdongAges 18–70 - NCT07024979Recruiting
Music therapy for university students' mental health
This trial tests whether a music therapy program can help university students with moderate stress, social problems, or trouble adjusting to college life. It aims to improve your mental health and well-being.
Hong KongAges 18–35 - NCT07033052Recruiting
Art therapy for anxiety and depression in teens
This trial tests whether art-based activities can help children and teens aged 8 to 17 who feel anxious or depressed. Parents must agree to let their child join.
Cleveland, OhioAges 8–17 - NCT07031661Recruiting
Bipolar disorder risk study for teens and children
This study follows children and teens who may be at higher risk for bipolar disorder to develop a prediction model. It includes three groups: those with a parent who has bipolar disorder, those with atypical depression, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT07020572Recruiting
Teen mood support program (iMATTER) in primary care
This study tests a group program to help teenagers with mild to moderate depression symptoms feel better. It takes place in primary care and uses a phone, computer, or tablet for activities.
Philadelphia, PennsylvaniaAges 13–17 - NCT07014852RecruitingEarly Phase 1
Inuit mental health trial with cultural foods and activities
This trial tests whether a program that includes traditional country foods, group conversations, and cultural workshops can improve mental health for Inuit adults. It is designed with Inuit knowledge to make the study feel supportive and relevant.
Arviat, NunavutAges 18–65 - NCT06988410Recruiting
Income changes and mental health study
This study looks at how ups and downs in income affect mental health. If you're a woman between 18 and 60 living with up to 4 other adults, you may be able to join.
TamaleAges 18–60 - NCT06996067Recruiting
Parent coaching texts after first baby in Nova Scotia
This trial tests a text message program to support new parents after childbirth. It aims to help you feel more confident and connected during the early weeks at home.
Halifax, Nova ScotiaAges 18 years+ - NCT07000799Enrolling by invitation
School absence and well-being study for elementary kids
This study tests a group program to help children who struggle with school attendance due to anxiety or sadness. It aims to boost well-being and reduce school avoidance.
OsloAges 8–13 - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT06985784Recruiting
Virtual reality for head and neck cancer patients and caregivers
This study tests whether using virtual reality can help reduce depression, anxiety, and pain in people with head and neck cancer and their caregivers. You and your caregiver may be able to use VR headsets together as part of your treatment.
Duarte, CaliforniaAges 18 years+ - NCT06987799Recruiting
Mindfulness for stress and high blood pressure
This study tests if a mindfulness program can help lower stress and blood pressure in people living in Chicago's South Side. You may join if you have high blood pressure and feel down or depressed.
Chicago, IllinoisAges 18 years+ - NCT06009523Recruiting
Testing brain stimulation for suicidal thoughts
This study tests a non-invasive brain stimulation technique called tDCS, which uses mild electrical currents to reduce suicidal thoughts in people with depression. If you have moderate to severe depression and still have suicidal ideation despite treatment, this might be an option.
Faye-l'AbbesseAges 18 years+ - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+ - NCT06979089Recruiting
Stress relief program for Dutch SMEs
This trial tests an online stress-management program for employees in small to medium-sized businesses in the Netherlands. It aims to help people with high stress levels feel better and cope more effectively.
Amsterdam, North HollandAges 18 years+ - NCT06978257Recruiting
Digital happiness skills study for anxiety and low mood
This study tests a smartphone-based program designed to boost positive feelings and reduce worry or low mood. It may help if you have mild to moderate anxiety or depression but are not severely affected or in crisis.
SingaporeAges 21–64 - NCT06981598Recruiting
Preventing mental health issues with unit-based support
This trial studies how having behavioral health technicians (mental health support people) work directly in military units can help prevent psychological problems. It is for service members who are currently seeing one of these technicians, or for the technicians themselves who are embedded in a unit.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.