Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06968650Recruiting
Cocooned Moms Support Study
This study tests a program that offers extra support to Black women during pregnancy. It aims to help moms feel safe, connected, and healthy.
Miami, FloridaAges 18 years+ - NCT06962527Recruiting
Study on how the brain handles uncertainty
This study uses brain imaging to understand how people react to uncertain situations. It may help develop better ways to treat anxiety and related conditions.
Chicago, IllinoisAges 25–60 - NCT06604481Recruiting
Online coaching for family caregivers
This study tests a 6-week online coaching program to help family caregivers reduce stress and build resilience. You'll learn practical strategies you can use at home.
Hong KongAges 18 years+ - NCT06951893Recruiting
Predicting quality of life after weight-loss surgery
This study looks at whether certain traits before weight-loss surgery can predict how a person's quality of life will change afterward. It aims to find patterns that could help doctors and patients make better decisions about treatment.
Chambéry, SavoieAges 18 years+ - NCT06948903Recruiting
Fibromyalgia, brain sensitivity and thinking
This study looks at how the brain's pain sensitivity (central sensitization) relates to memory and thinking problems in people with fibromyalgia. Participating could help doctors understand and treat these symptoms better.
Istanbul, UskudarAges 18–65 - NCT06936202Recruiting
Spirulina pill study for healthy adults
This study tests whether a supplement called spirulina (a type of algae) can improve mental health in healthy adults. You would take spirulina daily and have your mood and well-being checked over several weeks.
Phoenix, ArizonaAges 16–65 - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT06929208Recruiting
Music and heart rate during procedures
This trial studies how listening to music affects your heart rate and stress response during a procedure like surgery or a pain treatment. It may help you relax and feel more comfortable.
SingaporeAges 21–90 - NCT06455397Recruiting
Building emotional awareness and mental health for parents
This trial tests a program called BEAM that helps parents and caregivers of young children (ages 2–5) manage stress, depression, anxiety, or anger. You'll get support from a peer coach through check-ins and learn skills to feel better.
Winnipeg, ManitobaAges 18 years+ - NCT06923423Recruiting
Cognitive processing therapy for drug use and trauma in prison
This study tests if a type of therapy called cognitive processing therapy (CPT) can help people in prison who have both a drug use problem and trauma-related stress. If you qualify, you would receive CPT and be compared to those getting usual care.
Little Rock, ArkansasAges 18 years+ - NCT06927076Recruiting
DMT with propofol for depression
This study tests whether a combination of DMT (a psychedelic) and propofol (a sedative) can help treat depression. You will receive both medicines in a hospital setting, and the team will monitor your response.
BaselAges 21 years+ - NCT06423417Recruiting
LifeHack program for student mental wellbeing
This trial tests a program called LifeHack to see if it helps university students feel better mentally. You'll take part in an online program and answer questions about your wellbeing.
AmsterdamAges 16–99 - NCT06921512Recruiting
Chinese therapeutic exercise for anxiety and depression
This study tests whether a traditional Chinese mind-body exercise (Daoyin) can help people with mild to moderate anxiety and depression. It also looks at how the exercise might affect your body and mind.
ShanghaiAges 18–65 - NCT05553197Recruiting
Track mood during therapy using smartphone check-ins
This study looks at how mood changes between therapy sessions by having you answer short mood questions on your smartphone. It may help the researchers understand what support works best for people with mild-to-moderate depression.
Zurich, Canton of ZurichAges 18 years+ - NCT06901739Recruiting
Synbiotic for mental health in obesity
This trial tests if a synbiotic (a mix of probiotics and prebiotics) can improve mental health in people with obesity. It may help if you have obesity and also struggle with anxiety or depression.
Valencia, ValenciaAges 18–65 - NCT06907654Recruiting
Couples study for depression and relationship wellbeing
This study looks at how partners can support each other while coping with depression. Couples will use a mental health app for a short time to see if it helps improve mood and relationships.
Madison, WisconsinAges 18 years+ - NCT06902636Recruiting
Trauma care program for older adults living alone
This trial tests a special care program for older adults who live alone and have limb injuries. It aims to help them recover safely at home using smartphone support for three months.
Kaohsiung City, KaohsiungAges 65 years+ - NCT06903897Recruiting
Social Needs Screening for Chronic Disease Study
This study looks at how asking about social needs (like food, housing, or money worries) can help people with chronic conditions like high blood pressure, diabetes, asthma, or depression. It takes place in Family Medicine clinics and aims to improve overall health.
Worcester, MassachusettsAges Any age - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06898879Recruiting
Working together to improve mental health care for veterans
This study is for veterans getting mental health support through VA programs. It tests a way to improve teamwork between veterans and their care teams to make the care better.
San Diego, CaliforniaAges 18 years+ - NCT06897670Recruiting
Brain blood flow patterns in mood and memory disorders
This study uses a headband with light sensors (fNIRS) to measure blood flow in the brain while you do thinking tasks. It aims to understand differences in brain activity for people with depression, bipolar disorder, or mild memory loss.
Rochester, MinnesotaAges 18 years+ - NCT06898593Recruiting
Including patient goals in collaborative care
This trial looks at ways to better include your personal goals and concerns in your care if you're already in the Collaborative Care Model at Dartmouth Health. It aims to make your treatment more focused on what matters to you.
Concord, New HampshireAges 18–100 - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06900712Recruiting
Single-session program for sexual assault recovery
This trial tests a one-time session designed to help survivors of unwanted sexual contact or assault reduce symptoms of PTSD or depression. It may be a good fit if you live in Ohio and have had these symptoms for at least a month.
Cleveland, OhioAges 18–65
Hear when a new Depression trial opens
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.