Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05164744Recruiting
MRI study of heart tissue changes after COVID-19
This study uses a heart MRI to look for leftover (healing) changes in heart tissue after COVID-19. It may help researchers better understand what ongoing heart effects can happen after infection.
Brooklyn, New YorkAges 18 years+ - NCT05149573Recruiting
PEMF therapy for women with painful bladder symptoms
This trial studies whether a device that uses gentle pulsed electromagnetic waves (PEMF) can reduce symptoms in women with interstitial cystitis/bladder pain syndrome (IC/BPS). It may help if your symptoms are currently fairly severe and ongoing.
Winston-Salem, North CarolinaAges 18–80 - NCT05150483Recruiting
Study of a blood test in new severe breathing failure
This trial looks at how a test might help evaluate adults who come to the emergency room with a brand-new, sudden breathing problem that needs high-flow oxygen. It may help doctors identify what’s going on faster and guide care in the early hours.
Athens, AtticaAges 18 years+ - NCT04361994Recruiting
GErman Italian Spanish Takotsubo Registry
This registry studies people who have been diagnosed with Takotsubo syndrome (a temporary heart condition that can mimic a heart attack). It helps researchers learn about who gets it, what happens over time, and what factors may affect recovery.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT05107635Recruiting
Registry for people treated with AtriCure for IST or POTS
This registry collects information from people who are getting—or already had—treatment for IST or POTS using an AtriCure device. It helps researchers better understand outcomes and safety in real-world care.
Loma Linda, CaliforniaAges 18–100 - NCT05133245Enrolling by invitation
Study of genes in people with PHACE syndrome
This study looks at genetic (DNA) differences in people who have PHACE syndrome. It also includes an eye exam, and results may help doctors better understand the condition.
Nashville, TennesseeAges Any age - NCT05126810Recruiting
Standard versus personalized counseling for TP53 test results
This trial compares standard genetic counseling with a more personalized approach for people considering or receiving TP53 genetic testing. It may help by seeing which counseling style better supports you before and after testing for a TP53 inherited change.
Houston, TexasAges Any age - NCT05091645Recruiting
Testing a Greek version of a frailty screening for hip fracture patients
This trial checks whether a translated and culturally adapted questionnaire (called the Groningen Frailty Indicator) works well for people age 65+ who have a hip fracture and are having surgery. It may help care teams better understand frailty and plan support after surgery.
LarissaAges 65 years+ - NCT05075161RecruitingPhase 3
Pirfenidone to help prevent lung scarring in ARDS
This Phase 3 trial tests whether pirfenidone can prevent or reduce lung scarring (fibrosis) in adults with ARDS who are within about a week of their illness starting. It may help by lowering harmful inflammation and the body’s scarring response.
Milan, MIAges 18 years+ - NCT00177268Recruiting
Collecting blood and tissue samples in skin diseases research
This study collects blood, urine, and possibly small tissue samples to learn more about cutaneous T-cell lymphoma (CTCL) and either eczema or atopic dermatitis. It may help researchers better understand these skin conditions and improve future treatments.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04336644Recruiting
Checks heart rhythm continuously or intermittently during treatment
This study compares two ways of monitoring your heart rhythm while you start certain cancer treatments. It may help doctors detect heart rhythm changes earlier and decide which monitoring approach is better.
St Louis, MissouriAges 18 years+ - NCT05003986RecruitingPhase 2
Sparsentan for children with protein leaking kidney diseases
This Phase 2 study tests sparsentan in children with certain kidney diseases that cause high amounts of protein in the urine. It aims to see if the medicine can reduce kidney damage signals and protein leakage compared with standard care.
Los Angeles, CaliforniaAges 1–17 - NCT05027945RecruitingPhase 2
Stem cell transplant for people with VEXAS syndrome
This Phase 2 trial tests whether an allogeneic stem cell transplant (from a donor) can treat VEXAS syndrome. It may help calm the body’s overactive inflammation and improve symptoms in eligible adults.
Bethesda, MarylandAges 18–75 - NCT05040711Recruiting
Mindfulness app for serious illness patients and caregivers
This study tests whether a mindfulness training delivered through a phone or tablet can help people and their caregivers cope with serious illness. You may be eligible if you’re 60 or older (as a patient) or an adult caregiver, and if simple screening questionnaires suggest you could benefit.
Livingston, New JerseyAges 21 years+ - NCT05023005Recruiting
Strain-Counterstrain therapy for piriformis muscle pain
This trial tests a hands-on physical therapy technique called “strain-counterstrain” to reduce pain from the piriformis muscle. It may help people whose pain is coming from that specific muscle rather than the low back.
Loma Linda, CaliforniaAges 18–65 - NCT04942080Recruiting
Using CALR test results to track certain blood cancers
This study looks at how much of a specific gene change (CALR) you have, and whether it helps doctors diagnose and follow people with certain blood cancers over time. It mainly involves using samples and medical data rather than testing a new drug.
AngersAges 18 years+ - NCT04948658Recruiting
Freezing ovarian tissue to protect future fertility
This study looks at storing ovarian (ovary) tissue by freezing it for people at higher risk of losing fertility. It may help preserve options for having biological children later, especially for certain genetic conditions, cancer-related risks, or planned gonad removal.
Bethesda, MarylandAges 2–35 - NCT04953910RecruitingPhase 1
Oral decitabine for cancers with liver problems
This Phase 1 trial studies how a pill form of decitabine/cedazuridine behaves in the body and how safe it is for people whose livers don’t work normally. It may help doctors better understand dosing and safety in patients with hepatic impairment.
Houston, TexasAges 18 years+ - NCT04953897RecruitingPhase 1
Oral decitabine for cancer patients with kidney problems
This Phase 1 trial studies how an oral combination cancer medicine behaves in the body (dose handling and safety) in people with kidney impairment. It may help doctors learn the safest way to use this treatment when kidney function is reduced.
Houston, TexasAges 18 years+ - NCT04988555RecruitingPhase 1/Phase 2
Study of an investigational drug for high-risk acute leukemia
This Phase 1/2 study tests enzomenib (DSP-5336) in people with relapsed or hard-to-treat acute leukemia (and, in some places, certain other blood cancers). The goal is to see how the drug works and how safe it is, especially for leukemia cases with specific genetic changes (KMT2A/MLL or NPM1).
Newport Beach, CaliforniaAges 12 years+ - NCT04444128Recruiting
Testing heart risk assessment using MRI T1 mapping
This study checks whether an MRI heart scan measure called “T1 mapping” can improve how doctors estimate heart disease risk in everyday people. You may join if you’re an adult and can have a contrast-enhanced heart MRI safely.
Frankfurt am Main, HesseAges 18 years+ - NCT04859270Recruiting
Rehab support for survivors after cardiac arrest
This study looks at a “whole-person” support plan for people who survived a non-traumatic cardiac arrest. It aims to improve the survivor’s health and also help support family members as they recover.
TaipeiAges 20 years+ - NCT04909138Recruiting
Intermittent nerve stimulation instead of daily low-frequency therapy
This study tests whether switching from continuous implanted nerve stimulation to an intermittent schedule can keep pain relief for people with chronic back and/or leg pain. You would be compared in a structured study plan to see if the alternate dosing works for you and is safe.
Chicago, IllinoisAges 18–90 - NCT04871035Recruiting
Compare immunoadsorption vs plasma exchange for Guillain-Barré
This study tests whether immunoadsorption works as well as plasma exchange to improve symptoms in people with Guillain-Barré syndrome. The goal is to find which treatment helps recovery and is safer for patients.
Ulm, Baden-WurttembergAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.