Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05443906Recruiting
Home exercise program for people with neurodegenerative conditions
This trial studies whether a home exercise program is safe and helpful for people with certain neurodegenerative conditions, including X-linked adrenoleukodystrophy and DARS2-related disease, as well as some other similar diagnoses. You would be asked to do exercises at home and be assessed on your walking and strength/safety.
Baltimore, MarylandAges 5–75 - NCT04974593RecruitingPhase 3
Test breath testing to guide a lactose-free diet in IBS
This trial studies whether a breath test (hydrogen/methane lactose testing) can predict who with IBS will improve on a lactose-free diet. If you have moderate-to-severe IBS and regularly eat lactose-containing foods, the test result may help tailor your diet approach.
Jette, Brussels CapitalAges 18–75 - NCT05120752RecruitingPhase 3
Low FODMAP diet trial for IBS without lactose intolerance
This trial tests whether eating a low-FODMAP diet can reduce IBS symptoms in people who do not have lactose intolerance. It aims to improve moderate-to-severe IBS symptoms by changing what kinds of carbohydrates you eat.
Jette, Brussels CapitalAges 18–75 - NCT05293769Recruiting
Food diary questionnaire test for IBS and activity levels
This study checks whether a food questionnaire can reliably estimate what you eat, including certain carbs that can affect digestion (FODMAPs). It also looks at how the results relate to IBS symptoms and your self-reported physical activity.
Jette, Brussels CapitalAges 18–65 - NCT05412862Recruiting
Improving mood after a recent heart event
This study looks at whether increasing positive emotions after an acute heart problem (like a heart attack or unstable angina) can help patients feel and function better. You may be eligible if you had a recent heart event and are not currently getting enough physical activity.
Boston, MassachusettsAges 18–95 - NCT05382754Recruiting
Home sleep testing for children being checked for sleep apnea
This trial tests whether home sleep testing can help diagnose sleep apnea in children. It is for kids who are already being referred for an in-lab sleep study at CHOP.
Philadelphia, PennsylvaniaAges 5–12 - NCT05365282Recruiting
Check how a wrist artery procedure affects hand nerve symptoms
This study looks at whether a procedure on an artery in the wrist is linked to new or worsening nerve symptoms in the hand. It may help doctors understand who is at higher or lower risk and improve safety.
AarhusAges 18 years+ - NCT04783701Recruiting
CT scan timing to check bypass grafts after heart attack
This study looks at whether a special CT heart scan (CT angiography) can show how well bypass grafts are working in people who had a CABG after an acute coronary syndrome. It compares people managed with two anti-platelet medicines versus one aspirin, aiming to understand how well grafts stay open and guide care.
BergenAges 18 years+ - NCT05355415Recruiting
Eye imaging study for outer retina diseases using adaptive optics
This study uses a special, high-detail eye imaging machine to take clear pictures of the outer retina. It may help researchers understand these eye conditions better, and how the eye images look when people have an outer retinal disease.
Bethesda, MarylandAges 21 years+ - NCT05342584RecruitingPhase 1
Venetoclax plus intensive chemo for AML and advanced MDS
This early-phase study tests whether venetoclax combined with intensive chemotherapy can treat AML (acute leukemia) and certain advanced MDS. It’s for people who are newly diagnosed (or certain high-risk blood cancers) and can safely tolerate strong treatment.
The Bronx, New YorkAges 18–75 - NCT05325034Recruiting
Lipid-lowering plan after heart attack in adults
This study tests a cholesterol-lowering treatment plan for adults admitted for a Type 1 heart attack. It may help your care team choose guideline-based cholesterol goals and treatments after the event.
Wollongong, New South WalesAges 18 years+ - NCT05348564Recruiting
Family genetic screening methods for heart rhythm risk
This study compares two ways to find relatives who may carry a specific inherited genetic change. It may help your family learn faster who should get follow-up testing and care.
Lancaster, PennsylvaniaAges 18 years+ - NCT05355272RecruitingPhase 2
Growth hormone treatment for Gulf War illness with low growth hormone
This Phase 2 study tests whether replacing growth hormone can improve symptoms in veterans with Gulf War Illness and adult growth hormone deficiency. It also checks that the treatment is safe for people with stable medications and hormone regimens.
Houston, TexasAges 18–64 - NCT05284006Recruiting
Non-invasive tests for Morquio A
This trial studies Morquio A (MPS IVA) using non-invasive ways to measure how the body is working, and to better understand why the condition happens. If you have Morquio A, this may help researchers learn more and improve care.
Wilmington, DelawareAges Any age - NCT05263076Recruiting
Uterus transplant trial for women born without a working uterus
This trial studies uterus transplant surgery to help people with “absolute uterine factor infertility” (no working uterus) become pregnant using embryos made by IVF. It checks whether the donated uterus can support pregnancy and safe delivery for participants who meet strict medical and health requirements.
Houston, TexasAges 20–65 - NCT05267821RecruitingPhase 2/Phase 3
Testing anakinra to reduce inflammation in pediatric sepsis MODS
This study tests whether a medicine called anakinra can “turn down” harmful inflammation in children with severe illness from sepsis. It aims to improve organ function when multiple organs are starting to fail.
Birmingham, AlabamaAges 1 day–17 years - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70 - NCT05209568Enrolling by invitation
Study of immune reactions after eating gluten
This study looks at how your immune system responds when you eat gluten, including for people with celiac disease. You may be asked to follow a gluten-free diet first and then safely reintroduce gluten so researchers can measure immune changes.
Aurora, ColoradoAges 2–101 - NCT05242315RecruitingPhase 4
Long-acting tacrolimus after liver transplant
This trial studies whether taking an extended-release form of tacrolimus (a medicine to prevent transplant rejection) after a liver transplant works well for people who are followed at the University of Alberta. It may help simplify dosing and monitor safety and effectiveness after transplant.
Edmonton, AlbertaAges 18 years+ - NCT05219110Recruiting
More fluids for children sick with toxin E. coli
This study looks at whether giving extra (hyper) fluids early helps children with a high-risk E. coli stomach infection. The goal is to improve outcomes by supporting the kidneys during the illness.
Birmingham, AlabamaAges 9 months–21 years - NCT05192603Enrolling by invitation
Low FODMAP vs SSRD diet for IBS symptoms
This study compares two dietary approaches to see which one helps improve symptoms in people with irritable bowel syndrome (IBS). You may be asked to follow a specific diet plan and report how you feel over the study period.
MalmöAges 18–70 - NCT05150483Recruiting
Study of a blood test in new severe breathing failure
This trial looks at how a test might help evaluate adults who come to the emergency room with a brand-new, sudden breathing problem that needs high-flow oxygen. It may help doctors identify what’s going on faster and guide care in the early hours.
Athens, AtticaAges 18 years+ - NCT05184842RecruitingPhase 2
Weekly low-dose decitabine plus venetoclax for MDS or AML
This Phase 2 study tests a gentler weekly combination of two medicines—decitabine and venetoclax—for people with MDS, AML, or MDS/MPN. The goal is to improve blood counts and disease control while reducing side effects compared with more harsh treatments.
Sacramento, CaliforniaAges 18 years+ - NCT05188612Recruiting
Hospital patients with confirmed COVID-19 survey study
This study collects information from adults who are in the hospital for confirmed COVID-19. The goal is to better understand what happens during acute (early) COVID-19 and improve care.
Bologna, BolognaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.