Clinical trials
E-cigarette Use clinical trials
Below are recruiting e-cigarette use clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06610838Recruiting
Long-term health effects of vaping nicotine
This study looks at how long-term e-cigarette use affects your health. Researchers will follow people who vape nicotine regularly to understand risks and benefits over time.
Madison, WisconsinAges 21 years+ - NCT06066996RecruitingEarly Phase 1
Study of withdrawal symptoms when people vape less
This study looks at what happens when people who vape nicotine daily try to cut back. Researchers want to understand withdrawal symptoms and find better ways to help people reduce or quit vaping.
Baltimore, MarylandAges 21–55 - NCT06489249RecruitingEarly Phase 1
Study on vaping, inflammation, and blood vessel health
This study looks at how vaping (e-cigarettes) might affect inflammation and blood vessel health in young adults. You will be asked to take a drug called salsalate to see if it changes these effects.
Iowa City, IowaAges 18–24 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06373679Recruiting
Switch or Quit: A study for smokers who want to quit
This study helps adults 21 and older who have tried to quit smoking with a stop-smoking medication. You may be able to join if you want to try quitting again or want to reduce harm from tobacco.
Charleston, South CarolinaAges 21 years+ - NCT05896033Recruiting
Study how menthol cigarette rules affect current menthol smokers
This study looks at how changes in menthol cigarette and e-cigarette rules may affect people who currently smoke menthol cigarettes. You may be asked to complete phone-based reports (like a diary) about your smoking patterns.
Charleston, South CarolinaAges 21 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT03721822RecruitingPhase 1
Imaging how smoking affects lung inflammation in adults
This Phase 1 study uses special lung imaging to measure inflammation after different types of smoking or vaping. It looks at differences between people and may help researchers understand how smoking-related lung irritation develops.
Philadelphia, PennsylvaniaAges 18–45 - NCT05772845Recruiting
Study of quitting support for vaping and smoking withdrawal
This study looks at nicotine withdrawal symptoms in people who vape and/or smoke regularly. It may help improve how quitting support is tailored, based on how participants respond during the withdrawal period.
Buffalo, New YorkAges 21–50 - NCT06159608RecruitingEarly Phase 1
E-cigarette effects on blood vessels in young adults
This study looks at how e-cigarettes affect blood vessels in young adults. Researchers want to compare first-time vapers, experienced vapers, and non-vapers to see if there are differences between men and women.
Iowa City, IowaAges 18–24 - NCT06860698Recruiting
E-cigarettes and blood vessel health in young adults
This study looks at how using e-cigarettes with nicotine affects the small blood vessels in young adults. It compares regular e-cigarette users to non-users to understand potential health impacts.
Richmond, VirginiaAges 18–29 - NCT07124702Recruiting
Quitting dual cigarette and e-cigarette use in pregnancy
This study tests a program to help pregnant people under 21 weeks who smoke both cigarettes and e-cigarettes. The goal is to help them quit both, focusing on those with lower household income.
Buffalo, New YorkAges 18 years+ - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking
This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.
Columbus, OhioAges 21 years+ - NCT04616313Recruiting
MRI and breathing tests in people who vape
This study uses a special lung scan (MRI) and breathing tests to understand how vaping affects lung structure and function. It may help researchers learn what early lung changes happen after starting vaping, even if you don’t feel sick.
London, OntarioAges 16 years+ - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT06944847Recruiting
Vaping and smoking study for people with schizophrenia
This study looks at habits of vaping and smoking in people with schizophrenia. It may help researchers understand how to better support people who want to reduce or quit nicotine use.
Buffalo, New YorkAges 21–50 - NCT05906082Recruiting
Vape-free texting program for young adults in rural North Dakota
This pilot study tests whether vape-free coaching by text message can help people quit e-cigarettes. You may be eligible if you are a young adult who vapes daily and plans to quit within a month.
Milwaukee, WisconsinAges 18–24 - NCT07599462Recruiting
Better Communication for People Who Use Cigarettes and E-Cigarettes
This study tests new ways to talk with people about quitting or reducing cigarettes and e-cigarettes. Researchers want to understand what communication approaches work best for people using both products.
Chapel Hill, North CarolinaAges 18 years+ - NCT07167225Recruiting
E-cigarette and cannabis co-use in young adults
This study looks at how using e-cigarettes and cannabis together affects exposure to harmful chemicals in young adults aged 18-25. It aims to understand the risks of co-use to help guide healthier choices.
Buffalo, New YorkAges 18–25 - NCT05338801Recruiting
Study menthol effects in e-cigarette users
This study tests how menthol in e-cigarettes affects addiction-related feelings and exposure. You may be asked to visit a lab and temporarily stop vaping before each session.
Miami, FloridaAges 21–35 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT05932745Recruiting
Test of new e-cig ingredients in current adult users
This study tests how new e-cigarette ingredients affect adults who already use e-cigarettes. You may be asked to avoid tobacco and nicotine briefly before sessions so researchers can measure effects more clearly.
New Haven, ConnecticutAges 18 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+
Hear when a new E-cigarette Use trial opens
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Common questions
- Are there clinical trials for e-cigarette use?
- Yes. Clin2 currently lists 45 recruiting e-cigarette use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a e-cigarette use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a e-cigarette use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.