Clinical trials
E-cigarette Use clinical trials
Below are recruiting e-cigarette use clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07599462Recruiting
Better Communication for People Who Use Cigarettes and E-Cigarettes
This study tests new ways to talk with people about quitting or reducing cigarettes and e-cigarettes. Researchers want to understand what communication approaches work best for people using both products.
Chapel Hill, North CarolinaAges 18 years+ - NCT07398976Recruiting
E-Cigarette perception study in men vs women
This study compares how men and women perceive e-cigarettes. It looks at people who smoke cigarettes regularly and have tried e-cigarettes.
New Haven, ConnecticutAges 21–44 - NCT07167225Recruiting
Chemical exposure in young adults who use e-cigarettes and cannabis
This study looks at how young adults who use e-cigarettes, cannabis, or both are exposed to harmful chemicals. It aims to understand the health effects of using these products together.
Buffalo, New YorkAges 18–25 - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT07124702Recruiting
Quitting dual cigarette and e-cigarette use in pregnancy
This study tests a program to help pregnant people under 21 weeks who smoke both cigarettes and e-cigarettes. The goal is to help them quit both, focusing on those with lower household income.
Buffalo, New YorkAges 18 years+ - NCT07040566RecruitingPhase 2
Varenicline to help stop vaping
This trial tests whether varenicline, a medicine that reduces cravings, can help people quit using e-cigarettes that contain nicotine. You must be a daily nicotine vaper and live in Connecticut or South Carolina.
New Haven, ConnecticutAges 18 years+ - NCT07039292Enrolling by invitation
Can e-cigarettes help reduce smoking?
This study tests whether e-cigarettes can help people who smoke but have not wanted to use other treatments. If you currently smoke and have declined traditional options like nicotine patches or quitlines, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT06944847Recruiting
Vaping and smoking study for people with schizophrenia
This study looks at habits of vaping and smoking in people with schizophrenia. It may help researchers understand how to better support people who want to reduce or quit nicotine use.
Buffalo, New YorkAges 21–50 - NCT06922617Recruiting
Comparing e-cigarettes to standard quitting aids for people in addiction treatment
This study compares two ways to help people who are in treatment for substance use also quit or reduce smoking: using e-cigarettes or using standard nicotine replacement therapy (like patches or gum). If you're ready to make a change in your smoking, this could be a helpful option.
Charleston, South CarolinaAges 21 years+ - NCT06929520Recruiting
ENDS intervention for rural Hawaiian youth
This trial tests a culturally tailored program to reduce e-cigarette (ENDS) use among rural middle school students in Hawaii. It may help if you are a 6th to 8th grader on Hawaii Island.
Honolulu, HawaiiAges 10–14 - NCT06614504RecruitingPhase 2
Nicotine control for dual e-cigarette and cigarette users
This study is testing how to help people who both smoke cigarettes and use e-cigarettes. It looks at ways to control nicotine use to help you quit or cut back.
Providence, Rhode IslandAges 21 years+ - NCT05906082Recruiting
Vape-free texting program for young adults in rural North Dakota
This pilot study tests whether vape-free coaching by text message can help people quit e-cigarettes. You may be eligible if you are a young adult who vapes daily and plans to quit within a month.
Milwaukee, WisconsinAges 18–24 - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT04616313Recruiting
MRI and breathing tests in people who vape
This study uses a special lung scan (MRI) and breathing tests to understand how vaping affects lung structure and function. It may help researchers learn what early lung changes happen after starting vaping, even if you don’t feel sick.
London, OntarioAges 16 years+ - NCT06610838Recruiting
Long-term health effects of vaping nicotine
This study looks at how long-term e-cigarette use affects your health. Researchers will follow people who vape nicotine regularly to understand risks and benefits over time.
Madison, WisconsinAges 21 years+ - NCT06609109RecruitingPhase 1
Testing how cannabis affects e-cigarette use
This study is for daily e-cigarette users who also use cannabis at least once a week. It tests how cannabis affects vaping behavior. Researchers want to see if using cannabis changes how much or how people vape.
Baltimore, MarylandAges 21 years+ - NCT06489249RecruitingEarly Phase 1
Study on vaping, inflammation, and blood vessel health
This study looks at how vaping (e-cigarettes) might affect inflammation and blood vessel health in young adults. You will be asked to take a drug called salsalate to see if it changes these effects.
Iowa City, IowaAges 18–24 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06373679Recruiting
Switch or Quit: A study for smokers who want to quit
This study helps adults 21 and older who have tried to quit smoking with a stop-smoking medication. You may be able to join if you want to try quitting again or want to reduce harm from tobacco.
Charleston, South CarolinaAges 21 years+ - NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking
This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.
Columbus, OhioAges 21 years+ - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06159608RecruitingEarly Phase 1
E-cigarette effects on blood vessels in young adults
This study looks at how e-cigarettes affect blood vessels in young adults. Researchers want to compare first-time vapers, experienced vapers, and non-vapers to see if there are differences between men and women.
Iowa City, IowaAges 18–24 - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT06066996RecruitingEarly Phase 1
Study of withdrawal symptoms when people vape less
This study looks at what happens when people who vape nicotine daily try to cut back. Researchers want to understand withdrawal symptoms and find better ways to help people reduce or quit vaping.
Baltimore, MarylandAges 21–55
Hear when a new E-cigarette Use trial opens
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Common questions
- Are there clinical trials for e-cigarette use?
- Yes. Clin2 currently lists 46 recruiting e-cigarette use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a e-cigarette use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a e-cigarette use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.