Clinical trials
Electronic Cigarette Use clinical trials
Below are recruiting electronic cigarette use clinical trials, each written for real people, not researchers. We’re tracking 23 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06610838Recruiting
Long-term health effects of vaping nicotine
This study looks at how long-term e-cigarette use affects your health. Researchers will follow people who vape nicotine regularly to understand risks and benefits over time.
Madison, WisconsinAges 21 years+ - NCT06489249RecruitingEarly Phase 1
Study on vaping, inflammation, and blood vessel health
This study looks at how vaping (e-cigarettes) might affect inflammation and blood vessel health in young adults. You will be asked to take a drug called salsalate to see if it changes these effects.
Iowa City, IowaAges 18–24 - NCT06395415Recruiting
Mobile health program for young adult e-cigarette users
This study tests a mobile health program to help young adults ages 18–26 who use e-cigarettes regularly to reduce or quit. It uses text messages to support you, and you'll need to be interested in changing your vaping habits.
Chicago, IllinoisAges 18–26 - NCT06474299RecruitingPhase 4
Quit Smoking and Vaping With Patches and Pills
This study tests whether a combination of a nicotine patch plus a medication called varenicline can help people who both smoke and vape quit both. You'll get free medication and support to help you stop.
Madison, WisconsinAges 21 years+ - NCT06609109RecruitingPhase 1
Testing how cannabis affects e-cigarette use
This study is for daily e-cigarette users who also use cannabis at least once a week. It tests how cannabis affects vaping behavior. Researchers want to see if using cannabis changes how much or how people vape.
Baltimore, MarylandAges 21 years+ - NCT05338801Recruiting
Study menthol effects in e-cigarette users
This study tests how menthol in e-cigarettes affects addiction-related feelings and exposure. You may be asked to visit a lab and temporarily stop vaping before each session.
Miami, FloridaAges 21–35 - NCT07124702Recruiting
Quitting dual cigarette and e-cigarette use in pregnancy
This study tests a program to help pregnant people under 21 weeks who smoke both cigarettes and e-cigarettes. The goal is to help them quit both, focusing on those with lower household income.
Buffalo, New YorkAges 18 years+ - NCT06066996RecruitingEarly Phase 1
Study of withdrawal symptoms when people vape less
This study looks at what happens when people who vape nicotine daily try to cut back. Researchers want to understand withdrawal symptoms and find better ways to help people reduce or quit vaping.
Baltimore, MarylandAges 21–55 - NCT05555069Recruiting
Menthol-flavored vaping study for adult menthol cigarette smokers
This study looks at how menthol flavoring may affect whether adult menthol cigarette smokers switch to e-cigarettes. You may be asked to switch and use e-cigarettes over a set period, while researchers track your smoking behavior.
Kansas City, MissouriAges 21 years+ - NCT04907136Recruiting
Testing health warning labels on e-cigarettes
This study tests whether different health warning labels on an e-cigarette device change how people understand risks and use the product. You may be able to help by trying labeled ENDS device options in a lab setting.
Miami, FloridaAges 21–35 - NCT06291597Recruiting
Vaping study: effects on lungs and heart
This study is looking at how daily vaping affects your lungs and heart over time. If you vape every day, researchers want to monitor your health to spot any early warning signs.
QuébecAges 18 years+ - NCT07599462Recruiting
Better Communication for People Who Use Cigarettes and E-Cigarettes
This study tests new ways to talk with people about quitting or reducing cigarettes and e-cigarettes. Researchers want to understand what communication approaches work best for people using both products.
Chapel Hill, North CarolinaAges 18 years+ - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT07562295Recruiting
How Smoking Affects Gum Health
This study compares gum and tooth health in young adults who smoke cigarettes, e-cigarettes, or hookah. Researchers want to understand how each type of smoking affects your mouth and gums differently.
Homs, Homs GovernorateAges 18–25 - NCT07202039Recruiting
E-Cigarettes for Smokers on Buprenorphine
This study tests whether switching to electronic cigarettes can help reduce harm for people with opioid use disorder who are on buprenorphine and smoke daily. The goal is to see if e-cigarettes are a safer option than continuing to smoke regular cigarettes.
Greenville, South CarolinaAges 21 years+ - NCT03862924Recruiting
Study tests standardized e-cigarette effects in people with HIV who smoke
This study looks at how a specific e-cigarette affects health in people who have HIV and smoke cigarettes regularly. You might be able to join if you meet smoking, HIV care, and safety requirements and are not planning to quit right away.
Providence, Rhode IslandAges 18 years+ - NCT05703672RecruitingPhase 3
Switching smokers to e-cigarettes who do not want to quit
This study tests whether switching from regular cigarettes to e-cigarettes helps smokers who are not interested in quitting. You would also be offered varenicline and regular check-ins to compare outcomes over time.
Kansas City, MissouriAges 21 years+ - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT06856525RecruitingPhase 2/Phase 3
MRI scan to study lung health in e-cigarette users
This study tests a new type of MRI scan to see how e-cigarettes affect your lungs. It's for young adults who vape nicotine regularly. The results may help doctors understand vaping-related lung damage.
Durham, North CarolinaAges 18–35 - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65
Hear when a new Electronic Cigarette Use trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for electronic cigarette use?
- Yes. Clin2 currently lists 23 recruiting electronic cigarette use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a electronic cigarette use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a electronic cigarette use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.