Clinical trials
E-cigarette Use clinical trials
Below are recruiting e-cigarette use clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05932745Recruiting
Test of new e-cig ingredients in current adult users
This study tests how new e-cigarette ingredients affect adults who already use e-cigarettes. You may be asked to avoid tobacco and nicotine briefly before sessions so researchers can measure effects more clearly.
New Haven, ConnecticutAges 18 years+ - NCT05896033Recruiting
Study how menthol cigarette rules affect current menthol smokers
This study looks at how changes in menthol cigarette and e-cigarette rules may affect people who currently smoke menthol cigarettes. You may be asked to complete phone-based reports (like a diary) about your smoking patterns.
Charleston, South CarolinaAges 21 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT05772845Recruiting
Study of quitting support for vaping and smoking withdrawal
This study looks at nicotine withdrawal symptoms in people who vape and/or smoke regularly. It may help improve how quitting support is tailored, based on how participants respond during the withdrawal period.
Buffalo, New YorkAges 21–50 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT05338801Recruiting
Study menthol effects in e-cigarette users
This study tests how menthol in e-cigarettes affects addiction-related feelings and exposure. You may be asked to visit a lab and temporarily stop vaping before each session.
Miami, FloridaAges 21–35 - NCT03721822RecruitingPhase 1
Imaging how smoking affects lung inflammation in adults
This Phase 1 study uses special lung imaging to measure inflammation after different types of smoking or vaping. It looks at differences between people and may help researchers understand how smoking-related lung irritation develops.
Philadelphia, PennsylvaniaAges 18–45 - NCT03862924Recruiting
Study tests standardized e-cigarette effects in people with HIV who smoke
This study looks at how a specific e-cigarette affects health in people who have HIV and smoke cigarettes regularly. You might be able to join if you meet smoking, HIV care, and safety requirements and are not planning to quit right away.
Providence, Rhode IslandAges 18 years+ - NCT07604246Recruiting
How nicotine affects eye movements in e-cigarette users
This study looks at how nicotine from e-cigarettes affects eye movements and related behaviors. It involves two lab visits and may help understand nicotine's effects on the brain.
Columbus, OhioAges 21–50 - NCT05703672RecruitingPhase 3
Switching smokers to e-cigarettes who do not want to quit
This study tests whether switching from regular cigarettes to e-cigarettes helps smokers who are not interested in quitting. You would also be offered varenicline and regular check-ins to compare outcomes over time.
Kansas City, MissouriAges 21 years+ - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT06297005Recruiting
E-cigarette use in pregnancy and child health study
This study looks at how using e-cigarettes during pregnancy might affect children's health. If you are pregnant, smoke or vape, or are a non-smoker, you may be able to join and help us learn more.
DublinAges 18–46 - NCT07322432RecruitingPhase 2
The CONQUER trial: quitting vaping with e-cigarette reduction
This study tests whether gradually reducing nicotine in e-cigarettes helps people who vape quit completely. It is for adults who are ready to stop and want a structured program.
New York, New YorkAges 21 years+ - NCT07207850Recruiting
Parents helping teens quit vaping
This study tests a program where parents work together to help their teenager stop vaping. It is designed for teens who vape and a parent or guardian who wants to support them.
Omaha, NebraskaAges 15–18 - NCT05257629RecruitingPhase 3
Aggressive smoking quit program after heart problems
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
New Westminster, British ColumbiaAges 18 years+ - NCT07129265Enrolling by invitation
Understanding vape marketing study for youth
This study looks at how young people understand vape marketing. You might join a working group or a focus group to share your thoughts.
Boston, MassachusettsAges 13 years+ - NCT06909500Recruiting
Vaping cessation app for young adults
This trial tests a smartphone app called ACT on Vaping to help young adults quit vaping. It may help you if you are ready to stop using e-cigarettes and want support through a digital tool.
Seattle, WashingtonAges 18–30 - NCT06448351Recruiting
Changing nicotine in e-cigarettes to reduce harm
This study tests how changing the amount of nicotine in e-cigarettes affects people's behavior. It looks at two groups: young adults who already vape and older adult smokers who want to try vaping, to see if different nicotine levels can help reduce smoking or make vaping safer.
Columbus, OhioAges 21–65 - NCT06196489Recruiting
Quit vaping: program for young veterans
This trial tests a program to help young veterans quit vaping. You'll get support through your phone or computer to help you stop using nicotine.
San Diego, CaliforniaAges 18–30 - NCT07564648Recruiting
Menthol Cigarette Study: How Different Brands Affect Smoking
This study compares how your body and mind respond to your usual menthol cigarettes versus a new menthol cigarette. Researchers want to understand how different menthol cigarettes affect smoking behavior and cravings over two weeks.
Columbus, OhioAges 21 years+ - NCT04907136Recruiting
Testing health warning labels on e-cigarettes
This study tests whether different health warning labels on an e-cigarette device change how people understand risks and use the product. You may be able to help by trying labeled ENDS device options in a lab setting.
Miami, FloridaAges 21–35 - NCT04662658RecruitingPhase 1/Phase 2
Testing a special MRI gas scan of healthy lungs
This study tests a special MRI scan that uses a “hyperpolarized” gas to look at how well the lungs are working. It’s likely looking for safe imaging results and clear lung measurements in people without lung disease.
Charlottesville, VirginiaAges 18 years+
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Common questions
- Are there clinical trials for e-cigarette use?
- Yes. Clin2 currently lists 46 recruiting e-cigarette use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a e-cigarette use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a e-cigarette use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.