Clinical trials
E-cigarette Use clinical trials
Below are recruiting e-cigarette use clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06609109RecruitingPhase 1
Testing how cannabis affects e-cigarette use
This study is for daily e-cigarette users who also use cannabis at least once a week. It tests how cannabis affects vaping behavior. Researchers want to see if using cannabis changes how much or how people vape.
Baltimore, MarylandAges 21 years+ - NCT06614504RecruitingPhase 2
Nicotine control for dual e-cigarette and cigarette users
This study is testing how to help people who both smoke cigarettes and use e-cigarettes. It looks at ways to control nicotine use to help you quit or cut back.
Providence, Rhode IslandAges 21 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06922617Recruiting
E-cigarettes vs. Nicotine Replacement for Smoking in Substance Use Treatment
This study compares e-cigarettes to nicotine replacement therapy (like patches or gum) to help people who are in treatment for substance use disorder (like drugs or alcohol) quit or reduce smoking. It aims to find a safer way to cut back on cigarettes.
Charleston, South CarolinaAges 21 years+ - NCT06929520Recruiting
ENDS intervention for rural Hawaiian youth
This trial tests a culturally tailored program to reduce e-cigarette (ENDS) use among rural middle school students in Hawaii. It may help if you are a 6th to 8th grader on Hawaii Island.
Honolulu, HawaiiAges 10–14 - NCT07040566RecruitingPhase 2
Varenicline to help stop vaping
This trial tests whether varenicline, a medicine that reduces cravings, can help people quit using e-cigarettes that contain nicotine. You must be a daily nicotine vaper and live in Connecticut or South Carolina.
New Haven, ConnecticutAges 18 years+ - NCT07039292Enrolling by invitation
Can e-cigarettes help reduce smoking?
This study tests whether e-cigarettes can help people who smoke but have not wanted to use other treatments. If you currently smoke and have declined traditional options like nicotine patches or quitlines, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT03862924Recruiting
Study tests standardized e-cigarette effects in people with HIV who smoke
This study looks at how a specific e-cigarette affects health in people who have HIV and smoke cigarettes regularly. You might be able to join if you meet smoking, HIV care, and safety requirements and are not planning to quit right away.
Providence, Rhode IslandAges 18 years+ - NCT05703672RecruitingPhase 3
Switching smokers to e-cigarettes who do not want to quit
This study tests whether switching from regular cigarettes to e-cigarettes helps smokers who are not interested in quitting. You would also be offered varenicline and regular check-ins to compare outcomes over time.
Kansas City, MissouriAges 21 years+ - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT06448351Recruiting
Changing nicotine in e-cigarettes to reduce harm
This study tests how changing the amount of nicotine in e-cigarettes affects people's behavior. It looks at two groups: young adults who already vape and older adult smokers who want to try vaping, to see if different nicotine levels can help reduce smoking or make vaping safer.
Columbus, OhioAges 21–65 - NCT07129265Enrolling by invitation
Understanding vape marketing study for youth
This study looks at how young people understand vape marketing. You might join a working group or a focus group to share your thoughts.
Boston, MassachusettsAges 13 years+ - NCT06297005Recruiting
E-cigarette use in pregnancy and child health study
This study looks at how using e-cigarettes during pregnancy might affect children's health. If you are pregnant, smoke or vape, or are a non-smoker, you may be able to join and help us learn more.
DublinAges 18–46 - NCT07207850Recruiting
Parents helping teens quit vaping
This study tests a program where parents work together to help their teenager stop vaping. It is designed for teens who vape and a parent or guardian who wants to support them.
Omaha, NebraskaAges 15–18 - NCT06196489Recruiting
Quit vaping: program for young veterans
This trial tests a program to help young veterans quit vaping. You'll get support through your phone or computer to help you stop using nicotine.
San Diego, CaliforniaAges 18–30 - NCT06909500Recruiting
Vaping cessation app for young adults
This trial tests a smartphone app called ACT on Vaping to help young adults quit vaping. It may help you if you are ready to stop using e-cigarettes and want support through a digital tool.
Seattle, WashingtonAges 18–30 - NCT05257629RecruitingPhase 3
Aggressive smoking quit program after heart problems
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
New Westminster, British ColumbiaAges 18 years+ - NCT07322432RecruitingPhase 2
The CONQUER trial: quitting vaping with e-cigarette reduction
This study tests whether gradually reducing nicotine in e-cigarettes helps people who vape quit completely. It is for adults who are ready to stop and want a structured program.
New York, New YorkAges 21 years+ - NCT04907136Recruiting
Testing health warning labels on e-cigarettes
This study tests whether different health warning labels on an e-cigarette device change how people understand risks and use the product. You may be able to help by trying labeled ENDS device options in a lab setting.
Miami, FloridaAges 21–35 - NCT07108166Recruiting
COPD and Chronic Bronchitis: Switching from Cigarettes to Heat-Not-Burn Device
This study tests whether switching from regular cigarettes to a heated tobacco device (a product that heats rather than burns tobacco) can improve symptoms and lung function in people with moderate COPD and chronic bronchitis. Participants will be randomly assigned to either switch to the heated device or continue smoking cigarettes.
Clearwater, FloridaAges 40 years+ - NCT04662658RecruitingPhase 1/Phase 2
Testing a special MRI gas scan of healthy lungs
This study tests a special MRI scan that uses a “hyperpolarized” gas to look at how well the lungs are working. It’s likely looking for safe imaging results and clear lung measurements in people without lung disease.
Charlottesville, VirginiaAges 18 years+
Hear when a new E-cigarette Use trial opens
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Common questions
- Are there clinical trials for e-cigarette use?
- Yes. Clin2 currently lists 45 recruiting e-cigarette use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a e-cigarette use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a e-cigarette use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.