Clinical trials
Endodontics clinical trials
Below are recruiting endodontics clinical trials, each written for real people, not researchers. We’re tracking 51 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06574152Recruiting
Light therapy for pain relief after dental root surgery
This trial tests whether a special light treatment, called photobiomodulation, can help reduce pain and speed up healing after a specific type of dental surgery on the root of a tooth. The surgery involves a small cut in the gum, and the light may help the gum recover faster.
Houston, TexasAges 18 years+ - NCT04528979Recruiting
Tests a bioceramic filling material for root-canal treatment outcomes
This study looks at how well a bioceramic sealing material works for tooth root-canal treatment, including cases where previous treatment did not work. If you have certain types of tooth nerve inflammation or infection, you may be eligible to help compare outcomes and improve care.
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT04527705Recruiting
Testing endodontic retreatment in one versus two visits
This study compares doing tooth root-canal retreatment in one visit versus two visits. It’s meant to see which approach leads to better outcomes for teeth with infection at the root tip (apical periodontitis).
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT06955429Recruiting
Testing Biodentine XP for tooth fillings and root treatments
This study tests how well Biodentine XP works over time for fixing cavities or treating tooth roots in children and adults. It aims to see if this material is safe and lasts long in both baby teeth and permanent teeth.
KraainemAges 2 years+ - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT06500845Recruiting
Study of a new tooth crown made of high-performance polymer
This trial tests a new type of dental crown made of a strong plastic called PEEK for a back molar that has had a root canal. It looks at how well the crown fits, and may be a good option if your tooth is still mostly intact.
CairoAges 18–50 - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT07850167Recruiting
Pain during root canal treatment across menstrual stages
This study looks at how the menstrual cycle and menopause may affect pain during root canal treatment. It aims to help dentists better manage pain for women.
NiğdeAges 18 years+ - NCT07836920Recruiting
Comparing two tooth-restoration approaches after root canal treatment
This study compares two ways to restore teeth that have had root canals, focusing on back teeth. It aims to see which approach is more conservative and effective, which may help preserve more of your natural tooth and improve long-term outcomes.
Cairo, ManialAges 20–50 - NCT07779148Recruiting
Comparing irrigation methods for repeat root canal treatment
This study compares different ways of cleaning the root canal during a repeat root canal treatment. You may qualify if you have a single-rooted tooth with a failed root canal and are generally healthy.
MinyaAges 13–60 - NCT07767084Recruiting
Sealer type and pain after root canal treatment
This study compares two types of dental sealers (materials used to fill the root canal) to see if one causes less pain after the procedure. It may help you know what to expect and allow you to choose a treatment that reduces discomfort.
MinyaAges 18–45 - NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT07643311Recruiting
Comparing two types of tooth caps for root-canal-treated molars
This study compares two ways to restore (cap) back teeth that have had root-canal treatment and lost a cusp or more. Researchers want to see which method—computer-milled or 3D-printed crowns—works better and lasts longer.
Santiago, Santiago MetropolitanAges 18–70 - NCT06717230Recruiting
Comparing ways to restore a back tooth after root canal
This study tests three different methods (digital, conventional, and biomimetic) to restore a back tooth that had a root canal and needs a crown-like covering. It aims to find which approach works best over one year.
El-Sheikh Zayed City, Giza GovernorateAges 15 years+ - NCT07518901Enrolling by invitationPhase 4
New Nanoparticle Treatment for Root Canal Therapy
This study tests a new type of nanoparticle (tiny medical particles) called Ferumoxytol to help treat infected tooth roots. Researchers want to see if this approach works better than standard root canal treatments.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06643663Recruiting
Gum surgery for teeth with gum disease and failed root canal
This study tests a gum surgery technique (guided tissue regeneration) to help heal teeth that have both gum disease and a failed root canal. It looks at how well the tooth heals and how it affects your daily life.
HaryānaAges 16 years+ - NCT07501585Recruiting
Hyaluronic acid gel for infected back tooth surgery
This trial tests whether putting hyaluronic acid (a natural gel-like substance) into the bone during root-end surgery helps heal infections in first molars (back teeth) that didn't get better after a root canal. It may be a good option if you have a small, stubborn infection and your gums are healthy.
MoscowAges 18 years+ - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT05898035Recruiting
Testing symptoms after root-end dental surgery
This study looks at what symptoms you feel after endodontic microsurgery (a type of root-end tooth procedure). It will help doctors understand what to expect after surgery in properly selected patients.
IrbidAges 18–65 - NCT07192146Recruiting
Patient experiences after dental emergency treatment
This study looks at how patients feel after receiving emergency dental treatment for tooth pain. It aims to understand what factors affect their recovery and satisfaction.
BangkokAges 18 years+ - NCT07141459Recruiting
Laser disinfection for failed root canal treatment
This trial tests if using a special laser (810 nm diode) to disinfect the tooth after a second root canal treatment can reduce pain and inflammation. It aims to help patients whose previous root canal failed and who have a small infection around the tooth root.
CairoAges 20–40 - NCT06980870RecruitingPhase 2
Pain medicine before root canal for less discomfort
This study tests whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward. It's for people with a painful, inflamed tooth nerve who haven't already taken pain medicine for it.
RawalpindiAges 18–50 - NCT07036237Enrolling by invitation
Comparing pain relief rinses after root canal
This trial tests whether rinsing the tooth with either tramadol (a pain reliever) or dexamethasone (a steroid) after a root canal reduces pain better. It is for people with a single-rooted tooth that has a very painful, inflamed nerve.
Karachi, SindhAges 18–50 - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+
Hear when a new Endodontics trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for endodontics?
- Yes. Clin2 currently lists 51 recruiting endodontics studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a endodontics trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a endodontics trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.