Clinical trials
Endodontics clinical trials
Below are recruiting endodontics clinical trials, each written for real people, not researchers. We’re tracking 53 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07643311Recruiting
Comparing two types of tooth caps for root-canal-treated molars
This study compares two ways to restore (cap) back teeth that have had root-canal treatment and lost a cusp or more. Researchers want to see which method—computer-milled or 3D-printed crowns—works better and lasts longer.
Santiago, Santiago MetropolitanAges 18–70 - NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT06671743RecruitingPhase 3
Medication before root canal to reduce pain
This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.
AjmanAges 20–50 - NCT06642415Recruiting
High magnification microscope for tooth root surgery
This trial compares two ways of doing a special tooth surgery (endodontic microsurgery) to see if using a high-magnification microscope helps you feel better after the procedure. If you have a tooth that still hurts or stays infected after a previous root canal, this study might be for you.
Rohtak, HaryanaAges 18–55 - NCT06587048Recruiting
New bone window surgery for root canal infections
This trial tests a new way to perform root-end surgery using a special ultrasound device. It aims to treat infections at the tip of a tooth root by making a small opening in the bone, which may help you heal faster.
Rohtak, HaryanaAges 18–60 - NCT06312085Recruiting
Root canal study with new filling material
This study tests a new material for filling root canals after cleaning out an infection. It aims to see if the material helps the tooth heal successfully. You may qualify if you have an infected tooth that has never had a root canal before.
IstanbulAges 18–75 - NCT06977009Recruiting
Does tooth grinding relief help with post-dental pain?
This study tests whether reducing a tooth's contact with its opposite tooth before root canal treatment can lower pain after the procedure. It's for people with a dead nerve in a back molar that needs a crown.
Amman, Amman GovernorateAges 18–70 - NCT06562816RecruitingPhase 4
Comparing two pain relievers after root canal treatment
This study tests two different pain medicines (trypsin-chymotrypsin and naproxen sodium) to see which one works better for pain after a root canal. It may help you if you need a root canal and are generally healthy.
Karachi, SindhAges 18–45 - NCT07048171Recruiting
Bone graft and blood concentrate for tooth infection healing
This trial tests whether using a bone graft (allograft) together with your own blood concentrate (iPRF) and a collagen membrane helps heal the bone and gum around a tooth with a long-standing infection. It might be a good option if you have a tooth that keeps getting infected despite a root canal and has a deep pocket on the cheek side.
Rohtak, HaryanaAges 18 years+ - NCT07642596Recruiting
Root Canal Treatment Methods and Post-Procedure Pain
This study compares two different techniques for cleaning and shaping root canals (the nerve chambers inside teeth) to see which one causes less pain after treatment. If you have a dead nerve in a back lower tooth, this trial may help us understand the best way to treat it with minimal discomfort.
Eskişehir, OdunpazarıAges 18–65 - NCT07555366Recruiting
Healing after tooth extraction: two treatment approaches
This study compares two treatments applied to the socket (the hole left after a tooth is removed) to help it heal better. One treatment uses a product called microRepair, and the other uses chlorhexidine, a common antimicrobial rinse. The goal is to see which helps the extraction site heal faster and with fewer problems.
Roma, RMAges 18–75 - NCT07256561Recruiting
Testing simvastatin gel inside root canals for infection and pain
This study tests whether a gel containing simvastatin, a medicine usually used for cholesterol, can help fight infection and reduce inflammation inside a tooth's root canal. It might be a treatment option for people who have a failed root canal and still have a small infection at the tip of the tooth root.
CairoAges 20–40 - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT06196515RecruitingPhase 2/Phase 3
Study of a new nano-medication for infected tooth root canals
This trial tests whether a nano-scale calcium hydroxide paste works better than standard treatments for tooth infections. If you have a permanent molar with signs of infection around the root tip, this study may be an option.
CairoAges 21–49 - NCT06207253RecruitingPhase 2/Phase 3
Testing diclofenac gel for tooth root infections
This trial tests whether a special anti-inflammatory gel (diclofenac sodium) placed inside the tooth can help treat an infection at the root tip. It is for adults with a restorable tooth and no allergies to the medication.
CairoAges 18–50 - NCT06545084Recruiting
Better healing after root-end surgery using a special blood clot
This study tests whether adding a concentrated blood clot (L-PRF) to standard root-end surgery helps tooth-related infections heal faster and better. You may be a good fit if you have a persistent infection at the tip of a tooth root and need this type of surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06655454RecruitingPhase 2
Numbing medicine after root canal for pain relief
This study tests whether a long-acting numbing medication (bupivacaine) given after a root canal can reduce pain better than a standard short-acting numbing medicine. It is for people who need a root canal for a tooth that is causing sharp, constant pain.
New York, New YorkAges 18 years+ - NCT06660797Recruiting
Irrigation methods for root canal treatment
This trial tests different ways to flush and clean inside a tooth during root canal treatment. It aims to see which method best reaches deep into the tooth and reduces bacteria.
TantaAges 18–40 - NCT06785753RecruitingPhase 2
Cold therapy for tooth pain after root canal
This study tests whether applying cold (cryotherapy) to the tooth and gum can reduce pain after root canal treatment in people with severe tooth pain. It aims to find a safe, drug-free way to manage pain during the procedure.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06937853Recruiting
Genes and painkiller response for tooth pain
This trial tests whether your genes affect how well a common painkiller (NSAID) works for tooth pain after a root canal procedure. It may help find the best pain relief for you.
Erzurum, ErzurumAges 18–65 - NCT06960070Recruiting
Comparing different types of resin fillings for root‑canal‑treated molars
This study compares two types of resin onlays (custom‑made fillings) to see which works better for molars that have had a root canal. If you have a back tooth with a root canal and a cavity on the top and one side, this trial may help decide the best repair.
Mersin, MersinAges 18–84 - NCT07019298Recruiting
Comparing dental filling methods for root canals
This trial studies different ways to fill a root canal after treatment to see which works best. It may help if you have a tooth with an infected or dying nerve.
Madrid, SpainAges 18 years+ - NCT07210359Recruiting
New treatment for immature teeth
This trial tests a regenerative treatment for immature permanent teeth (front teeth with developing roots) in children and teens. The goal is to help the tooth's pulp heal and allow the root to continue growing naturally.
Kafr ash Shaykh, Kafr ElsheikhAges 9–15 - NCT07343804Recruiting
Dental root canal and heart disease risk study
This trial tests whether treating a tooth infection with a root canal can lower blood markers linked to heart risk in people with stable heart disease.
Rohtak, HaryanaAges 30 years+
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Common questions
- Are there clinical trials for endodontics?
- Yes. Clin2 currently lists 53 recruiting endodontics studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a endodontics trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a endodontics trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.