Clinical trials
Endodontics clinical trials
Below are recruiting endodontics clinical trials, each written for real people, not researchers. We’re tracking 51 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06312085Recruiting
Root canal study with new filling material
This study tests a new material for filling root canals after cleaning out an infection. It aims to see if the material helps the tooth heal successfully. You may qualify if you have an infected tooth that has never had a root canal before.
IstanbulAges 18–75 - NCT07808424Recruiting
Comparing two ways to place MTA in root-end surgery for back teeth
This study compares two ways of placing a special filling material (MTA) at the root tip during a surgical procedure called apicoectomy (removing the tip of the root). One method is done from the top of the tooth (orthograde), and the other is done from the bottom (retrograde). The goal is to see which method works better for saving a tooth with a persistent infection after a root canal.
Rohtak, HaryanaAges 18–55 - NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT06642415Recruiting
High magnification microscope for tooth root surgery
This trial compares two ways of doing a special tooth surgery (endodontic microsurgery) to see if using a high-magnification microscope helps you feel better after the procedure. If you have a tooth that still hurts or stays infected after a previous root canal, this study might be for you.
Rohtak, HaryanaAges 18–55 - NCT06660797Recruiting
Irrigation methods for root canal treatment
This trial tests different ways to flush and clean inside a tooth during root canal treatment. It aims to see which method best reaches deep into the tooth and reduces bacteria.
TantaAges 18–40 - NCT06562816RecruitingPhase 4
Comparing two pain relievers after root canal treatment
This study tests two different pain medicines (trypsin-chymotrypsin and naproxen sodium) to see which one works better for pain after a root canal. It may help you if you need a root canal and are generally healthy.
Karachi, SindhAges 18–45 - NCT06671743RecruitingPhase 3
Medication before root canal to reduce pain
This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.
AjmanAges 20–50 - NCT07642284Recruiting
Root Canal Sealer Performance Study
This study tests how well a new root canal sealant (AH Plus Jet) works when used with a simplified filling technique. Root canal treatment removes infected nerve tissue from inside a tooth, and this trial evaluates whether this newer sealant keeps the tooth healthy long-term.
New York, New YorkAges 18–75 - NCT07642596Recruiting
Root Canal Treatment Methods and Post-Procedure Pain
This study compares two different techniques for cleaning and shaping root canals (the nerve chambers inside teeth) to see which one causes less pain after treatment. If you have a dead nerve in a back lower tooth, this trial may help us understand the best way to treat it with minimal discomfort.
Eskişehir, OdunpazarıAges 18–65 - NCT07599254RecruitingPhase 4
Pain Relief After Root Canal Retreatment
This study tests two different ways of cleaning and treating a tooth that had a root canal treatment before. Researchers want to see which method causes less pain after the procedure.
KayseriAges 18–60 - NCT07555366Recruiting
Healing after tooth extraction: two treatment approaches
This study compares two treatments applied to the socket (the hole left after a tooth is removed) to help it heal better. One treatment uses a product called microRepair, and the other uses chlorhexidine, a common antimicrobial rinse. The goal is to see which helps the extraction site heal faster and with fewer problems.
Roma, RMAges 18–75 - NCT07465978Recruiting
Testing printed hybrid resin for dental overlays
This trial tests a special printed material used for tooth overlays (caps that cover the entire top of a back tooth). If you need a full overlay on a molar that has had root canal treatment, this study may be a good fit.
Sant Cugat del Vallès, BarcelonaAges 18 years+ - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50 - NCT07343804Recruiting
Dental root canal and heart disease risk study
This trial tests whether treating a tooth infection with a root canal can lower blood markers linked to heart risk in people with stable heart disease.
Rohtak, HaryanaAges 30 years+ - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07256561Recruiting
Testing simvastatin gel inside root canals for infection and pain
This study tests whether a gel containing simvastatin, a medicine usually used for cholesterol, can help fight infection and reduce inflammation inside a tooth's root canal. It might be a treatment option for people who have a failed root canal and still have a small infection at the tip of the tooth root.
CairoAges 20–40 - NCT07210359Recruiting
New treatment for immature teeth
This trial tests a regenerative treatment for immature permanent teeth (front teeth with developing roots) in children and teens. The goal is to help the tooth's pulp heal and allow the root to continue growing naturally.
Kafr ash Shaykh, Kafr ElsheikhAges 9–15 - NCT06977009Recruiting
Does tooth grinding relief help with post-dental pain?
This study tests whether reducing a tooth's contact with its opposite tooth before root canal treatment can lower pain after the procedure. It's for people with a dead nerve in a back molar that needs a crown.
Amman, Amman GovernorateAges 18–70 - NCT07048171Recruiting
Bone graft and blood concentrate for tooth infection healing
This trial tests whether using a bone graft (allograft) together with your own blood concentrate (iPRF) and a collagen membrane helps heal the bone and gum around a tooth with a long-standing infection. It might be a good option if you have a tooth that keeps getting infected despite a root canal and has a deep pocket on the cheek side.
Rohtak, HaryanaAges 18 years+ - NCT06207253RecruitingPhase 2/Phase 3
Testing diclofenac gel for tooth root infections
This trial tests whether a special anti-inflammatory gel (diclofenac sodium) placed inside the tooth can help treat an infection at the root tip. It is for adults with a restorable tooth and no allergies to the medication.
CairoAges 18–50 - NCT07019298Recruiting
Comparing dental filling methods for root canals
This trial studies different ways to fill a root canal after treatment to see which works best. It may help if you have a tooth with an infected or dying nerve.
Madrid, SpainAges 18 years+ - NCT06960070Recruiting
Comparing different types of resin fillings for root‑canal‑treated molars
This study compares two types of resin onlays (custom‑made fillings) to see which works better for molars that have had a root canal. If you have a back tooth with a root canal and a cavity on the top and one side, this trial may help decide the best repair.
Mersin, MersinAges 18–84 - NCT06959602Enrolling by invitation
Comparing two root canal cleaning methods for infected teeth
This trial compares two ways of cleaning infected root canals during a root canal procedure. The goal is to see which method better removes bacteria and improves healing.
AthensAges 18–80 - NCT06934317Enrolling by invitation
Bite force after root canal treatment vs. regenerative therapy
This trial compares how strongly you can bite down on a tooth that has had a root canal or a newer regenerative treatment. It is for people with a dead nerve inside a permanent tooth who are otherwise healthy.
IrbidAges 10–60
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Common questions
- Are there clinical trials for endodontics?
- Yes. Clin2 currently lists 51 recruiting endodontics studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a endodontics trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a endodontics trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.