Clinical trials · San Jose, CA
Head and Neck Cancer clinical trials in San Jose
We’re tracking 19 recruiting head and neck cancer studies with a site in or near San Jose — including Phase 1, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near San Jose
- NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
San Jose, CaliforniaAges 18 years+ - NCT07059884Recruiting
Exercise program to help people with cancer stay active
This trial tests a distance-based exercise program designed to help people on chemotherapy maintain their physical function and prevent disability. It is for patients with certain cancers who are working full-time and can participate in moderate physical activity.
San Jose, CaliforniaAges 18 years+ - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
San Jose, CaliforniaAges 18 years+ - NCT05406167Recruiting
Tracking quality of life during radiotherapy with a new system
This study collects information about how you feel and how treatment is delivered while you receive radiotherapy using the RefleXion Medical radiotherapy system. It may help doctors improve care and better understand what affects quality of life during treatment.
Palo Alto, CaliforniaAges Any age - NCT06589804RecruitingPhase 3
Testing cetuximab plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding cetuximab to the standard drug pembrolizumab works better for head and neck cancer that has spread or come back after treatment. It is for people whose cancer did not respond to platinum chemotherapy and whose tumors have a certain immune marker (PD-L1).
Palo Alto, CaliforniaAges 18 years+ - NCT06525220RecruitingPhase 3
New drug combo vs. standard for head and neck cancer
This trial tests a new combination of two immunotherapy drugs (petosemtamab plus pembrolizumab) compared to pembrolizumab alone for people with head and neck cancer that has spread or come back and cannot be cured locally. It may be an option if your cancer has a certain protein (PD-L1) and you haven't had prior cancer treatment for this stage.
Palo Alto, CaliforniaAges 18 years+ - NCT05176483RecruitingPhase 1
New drug combinations for advanced solid tumors
This trial tests a new drug called zanzalintinib, which may slow or shrink various types of advanced cancer. It is given together with other cancer treatments, and the study is looking at many different cancers including kidney, prostate, bladder, lung, liver, and more.
Palo Alto, CaliforniaAges 18 years+ - NCT06496178RecruitingPhase 3
Petosemtamab for advanced head and neck cancer after prior treatment
This trial tests a new drug called petosemtamab for people with head and neck cancer that has gotten worse after immunotherapy and platinum chemotherapy. The goal is to see if it works better than the standard single-drug options available.
Palo Alto, CaliforniaAges 18 years+ - NCT04534205RecruitingPhase 2/Phase 3
Testing BNT113 plus pembrolizumab versus pembrolizumab alone
This trial studies whether adding BNT113 to pembrolizumab works better and is safe for people with HPV16-positive head and neck cancer that can’t be cured with local treatments. It also compares outcomes to pembrolizumab alone, specifically for tumors that show PD-L1 in testing.
Palo Alto, CaliforniaAges 18 years+ - NCT04981119Recruiting
Test apheresis for CAR T manufacturing in HLA-A2 solid tumors
This trial studies how a process called apheresis is used to make CAR T cells for people with certain solid tumors. It is designed for tumors that have lost a specific immune marker (HLA-A*02), which may affect how well CAR T therapies work.
Palo Alto, CaliforniaAges 18 years+ - NCT06163534Recruiting
Biomarker profiling study for advanced head and neck cancer patients
This study collects blood and tumor tissue samples to analyze biological markers in patients with advanced head and neck squamous cell carcinoma before starting immunotherapy. The goal is to better understand how these markers relate to treatment response.
Palo Alto, CaliforniaAges 18 years+ - NCT06788990RecruitingPhase 2/Phase 3
Study of ficerafusp alfa with pembrolizumab for advanced head and neck cancer
This study tests a new drug called ficerafusp alfa (BCA101) combined with the immunotherapy pembrolizumab for people with advanced head and neck cancer that has not been treated before. The goal is to see if adding ficerafusp alfa helps shrink tumors better than pembrolizumab alone.
Stanford, CaliforniaAges 18 years+ - NCT00568490Recruiting
Finding blood markers that show low oxygen in tumors
This study looks for substances in blood that may reflect how “low-oxygen” a tumor is. If you have head and neck cancer or non-small cell lung cancer, it may help researchers understand tumor oxygen levels and improve future care.
Stanford, CaliforniaAges 18 years+ - NCT00230308Recruiting
Study of new genes in head and neck cancer surgery tissue
This study looks at tissue from people having surgery for head and neck cancer at Stanford University. Researchers want to identify new proteins and genes that may help explain the cancer and guide future treatments.
Stanford, CaliforniaAges 18 years+ - NCT06736379RecruitingPhase 1
RNA Therapy Injections for Head and Neck Cancer
This trial tests a new type of immunotherapy made of self-amplifying RNA (saRNA) that produces a protein called IL-12. It's injected directly into head and neck tumors to help your immune system fight the cancer. The study is for people whose cancer has not responded well to standard treatments or who are having surgery to remove their tumor.
Stanford, CaliforniaAges 18 years+ - NCT07276399RecruitingPhase 3
Study of amivantamab plus standard care for head and neck cancer
This trial tests whether adding the drug amivantamab to usual treatments helps people with advanced head and neck cancer that has come back or spread. It compares the combination to standard care alone.
Stanford, CaliforniaAges 18 years+ - NCT04119024RecruitingPhase 1
Gene-edited immune cells for advanced melanoma or solid tumors
This Phase 1 study tests a gene-modified immune cell treatment for advanced cancers that don’t have standard curative options. It may help by attacking cancer cells that show a specific marker called IL13Rα2 after patients receive “conditioning” chemotherapy to prepare the immune system.
Stanford, CaliforniaAges 18–75 - NCT05059444Recruiting
Blood test study to watch for cancer coming back
This study looks at whether blood tests can detect signs that cancer may return after curative-intent treatment. You would have blood drawn around your usual follow-up visits for up to 5 years, and your de-identified health data would be shared with study investigators.
Redwood City, CaliforniaAges 18 years+ - NCT05334069Recruiting
Blood test study for early cancer detection in patients
This study collects blood from people with cancer and people without cancer (or with possible cancer) to test whether new blood tests can detect cancer earlier. Your blood samples help researchers evaluate how well these tests work.
Dublin, CaliforniaAges 40–75
Hear when a new Head and Neck Cancer trial opens near San Jose, CA
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Head and Neck Cancer trials in other cities
Where these studies are running near San Jose
Institutions with a site for the recruiting head and neck cancer studies listed above.
- Stanford University · 6 studies
- Kaiser Permanente Dublin · 2 studies
- Kaiser Permanente Fremont · 2 studies
- Kaiser Permanente-Santa Teresa-San Jose · 2 studies
- Stanford Cancer Institute · 2 studies
- Epic Care-Dublin
- Exelixis Clinical Site #123
- Kaiser Permanente Medical Center - Santa Clara
What taking part in a head and neck cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting head and neck cancer studies in California.
Common questions
- Are there head and neck cancer clinical trials near San Jose?
- Yes. We're currently tracking 19 recruiting head and neck cancer studies with a site near San Jose, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a head and neck cancer study near San Jose?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Jose to take part?
- Not necessarily. These studies have a site near San Jose, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a head and neck cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New head and neck cancer studies open near San Jose regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.