Study of CTX-8371 for advanced cancers no longer helped by standard therapy
Part of Blood & lymphatic, Cancer, Immune system & allergy, Lungs & breathing, Skin clinical trials.
This trial tests a new drug called CTX-8371 for people with advanced cancers (melanoma, head and neck, lung, triple-negative breast, or Hodgkin lymphoma) that have stopped responding to standard treatments, especially immunotherapy. It is a first-in-human study, meaning doctors are learning if the drug is safe and how well it works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have one of these cancers: melanoma, head and neck, lung, triple-negative breast, or Hodgkin lymphoma that has spread and is no longer responding to standard treatments.
- You have tried at least one previous immunotherapy (like a PD-1/PD-L1 drug) and it stopped working, and you had your last dose within the past 3 months.
- You have tumors that can be measured on scans, and you are generally able to do your daily activities (not bedridden).
- Your blood counts, liver, and kidney function are at a safe level based on recent tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests NX-1607 in adults with advanced cancers that are hard to treat with standard care. It focuses on safety and early signs of how well the drug may work in specific cancer types.
This trial tests a new targeted drug (LY4175408) for people with certain advanced solid tumors (lung, endometrial, or triple negative breast cancer) who have already tried standard treatments. The goal is to see if the drug is safe and effective.
This trial tests a new drug called CTX-10726 in people with advanced kidney, liver, stomach, or uterine cancer that has not responded to standard treatments. The goal is to see if the drug is safe and tolerable.
This trial tests a new drug called CX-801 for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if it can shrink tumors or slow their growth.
This trial tests a new drug called PTX-912 for people with advanced or metastatic solid tumors that have not responded to standard treatments. It is a first-in-human study, meaning this is the first time PTX-912 is being given to people, to see how safe it is and how well it works.
This trial tests a new drug, HLX43, by itself or combined with other immunotherapy drugs for people with advanced triple-negative breast cancer (TNBC) that has spread or cannot be removed by surgery. The goal is to see if these treatments can shrink tumors or slow cancer growth.
Hear when a new Non Small Cell Lung Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.