Clinical trials
Hypogonadism clinical trials
Below are recruiting hypogonadism clinical trials, each written for real people, not researchers. We’re tracking 35 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07761546Enrolling by invitation
Ai-test: microbiome nutrition for low testosterone
This study tests whether a special diet can improve symptoms of low testosterone in men. It is intended to help men with certain symptoms like a low sex drive or trouble having erections and whose blood tests show low to borderline testosterone levels.
AydinAges 30–65 - NCT07476222Recruiting
Predicting testosterone decline in middle-aged men
This study looks at why testosterone levels drop in men aged 35-59. It may help identify early signs and ways to prevent it.
AndijanAges 35–59 - NCT05611307Recruiting
Heart Health in Testicular Cancer Survivors
This study looks at heart health in men who have survived testicular cancer. It compares those who had different treatments (surgery, chemotherapy, or chemotherapy plus a stem cell transplant) to see if there are hidden signs of heart or blood vessel problems.
Indianapolis, IndianaAges 18–99 - NCT03851627RecruitingPhase 4
Testosterone for fatty liver in overweight men with diabetes
This trial compares testosterone undecanoate versus a placebo (inactive pill) to see if it lowers fat in the liver measured by MRI. It focuses on overweight or obese men who have prediabetes or type 2 diabetes and low testosterone confirmed by blood tests.
ViennaAges 18–75 - NCT04760574Recruiting
HIV status and low testosterone in men
This study looks at whether low testosterone (often called male hypogonadism) is linked to having HIV. It compares HIV-positive men with HIV-negative men to better understand what contributes to hormone problems and how common they are.
TaipeiAges 20 years+ - NCT04798469RecruitingPhase 2
Testosterone to reduce long-term spine pain in men on opioids
This Phase 2 study tests whether taking testosterone can lessen chronic non-cancer spinal pain in men who have low testosterone while using opioid pain medicines. It may help by improving hormone levels that could be affecting pain and overall wellbeing.
Boston, MassachusettsAges 18 years+ - NCT06247267Recruiting
Hormone replacement therapy in military members
This study is looking at how sex hormone replacement therapy affects active-duty military members and their families. It aims to understand the effects in people with low testosterone or those receiving gender-affirming hormones.
Bethesda, MarylandAges 18–65 - NCT06689085RecruitingPhase 3
Testosterone replacement study for adolescent boys with low testosterone
This trial tests a testosterone injection (XYOSTED) to see if it's safe and effective for replacing testosterone in teenage boys who have low levels due to a known medical condition. It lasts 52 weeks, with an optional 2-year follow-up.
Los Angeles, CaliforniaAges 12–17 - NCT06691815Enrolling by invitation
Triptorelin test for diagnosing delayed puberty
This study uses a hormone called triptorelin to help doctors find the cause of delayed or stalled puberty in teenagers and young adults. The goal is to see if this medicine can clearly tell whether the problem is in the brain or elsewhere in the body.
Buenos AiresAges 13 years+ - NCT06455969RecruitingPhase 4
Stress and recovery training study
This study looks at how the body handles stress, using different hormone levels to create specific conditions in healthy young adults. It aims to understand the body's response and recovery, which may help people build resilience to stress.
Pittsburgh, PennsylvaniaAges 18–40 - NCT07049042Recruiting
Hormone study in genetic brain development conditions
This study looks at whether certain genetic brain development conditions affect hormone production in the body. It may help find out if people with these conditions have low sex hormones.
Sheffield, SelectAges birth–99 years - NCT05569577Recruiting
Extra hCG injections to help pregnancy in IHH
This trial studies whether adding extra hCG shots improves pregnancy outcomes for people diagnosed with IHH, a hormone-related cause of not starting periods. If you’re trying to get pregnant, it may help test whether this added treatment improves your chances.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT05058781Recruiting
Study of early hormone changes in newborns at risk
This trial looks at “minipuberty,” a normal early hormone window in newborns, in babies who may have hormone-signaling problems. It may help doctors understand what to watch for and how early care could be planned.
Lausanne, Canton of VaudAges Up to 9 months - NCT01500447Recruiting
Study of inherited causes of low puberty hormones
This study looks at families to understand inherited (genetic or family-related) reasons some people have delayed puberty or develop puberty abnormally. It may help doctors better figure out the cause of low sex hormone levels and related hormone problems.
Bethesda, MarylandAges 1 month–120 years - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT04460872RecruitingPhase 2
Testosterone plus walking training to support bones and muscles
This Phase 2 study tests whether testosterone therapy combined with walking training can improve bone and muscle health after a spinal cord injury. It aims to help men with low testosterone and walking problems by improving strength, body composition, and related health markers.
Gainesville, FloridaAges 18 years+ - NCT04833426RecruitingPhase 3
Testosterone levels around prostate surgery and recovery outcomes
This trial studies whether testosterone levels before and around radical prostate surgery affect cancer control and sexual/physical recovery. It may help doctors understand who benefits from testosterone replacement and who should not.
AmsterdamAges 18 years+ - NCT05896293RecruitingPhase 2
Kisspeptin shots for low hormone condition
This study tests if a hormone called kisspeptin can help people with a condition that limits sex hormones. The trial involves regular shots under the skin.
Boston, MassachusettsAges 18 years+ - NCT05249634RecruitingPhase 2
Testosterone treatment study for men with chronic kidney disease
This Phase 2 study tests whether testosterone therapy can help men with chronic kidney disease who have low testosterone and related symptoms. It looks to see if treatment is safe and beneficial, while carefully checking heart, blood, prostate, and clotting risks.
St Louis, MissouriAges 18–85 - NCT06019182Recruiting
MEHMO syndrome: Understanding the condition over time
This study follows people with or at risk for MEHMO syndrome over time to better understand the condition and identify biological markers. It may include both affected individuals and their family members to see how the condition runs in families.
Bethesda, MarylandAges 1 week–100 years - NCT06280807Recruiting
Observation of Environment and Reproductive Health Effects
This study looks at how the environment and your body's natural hormones interact. It is for people with reproductive or hormone-related conditions such as low sex hormones (hypogonadism), infertility, early or late puberty, PCOS, or menopause. The researchers will observe participants over time to learn more about these conditions.
Research Triangle Park, North CarolinaAges 8–99 - NCT06357442Recruiting
Comparing progesterone methods for young people on estrogen therapy
This study compares two ways to give progesterone to young people on estrogen replacement therapy to see how they affect the lining of the uterus. It will help find which approach may be safer and more effective for your health.
Aurora, ColoradoAges 12–25 - NCT06532149Recruiting
Sexual health and erectile function in men with lung cancer
This study looks at how lung cancer and its treatments affect men's sexual health, including erectile function and hormone levels. If you are a man with advanced lung cancer and are sexually active, researchers want to learn about your experiences and test results.
RomeAges 18–75 - NCT06544473RecruitingPhase 4
Estrogen pill vs. patch for Turner syndrome
This trial compares oral and transdermal (patch) estrogen to find the right dose for women with Turner syndrome. It aims to see which method works best for hormone replacement.
Aarhus, Aarhus NAges 18–50
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Common questions
- Are there clinical trials for hypogonadism?
- Yes. Clin2 currently lists 35 recruiting hypogonadism studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypogonadism trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypogonadism trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.