Clinical trials · California
Malignant Solid Neoplasm clinical trials in California
We’re tracking 75 recruiting malignant solid neoplasm studies with a site in California — including Early Phase 1, Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06587100Recruiting
Activity tracker to prevent hospital stays during cancer treatment
This study tests whether using a wearable activity tracker can help reduce hospitalizations in people undergoing radiation therapy for cancer. Participants will wear a tracker to monitor their activity levels during treatment.
San Francisco, CaliforniaAges 18 years+ - NCT05733949RecruitingEarly Phase 1
Targeted radiation for people with many solid tumor metastases
This trial tests a precise type of radiation that targets multiple tumor spots in a carefully planned way. It may help people with many metastatic (spread) solid tumors when standard treatments aren’t working or can’t be used.
Duarte, CaliforniaAges 18 years+ - NCT05327010RecruitingPhase 2
Testing a new drug combination for advanced solid tumors
This trial is studying whether a new combination of two cancer drugs, ZEN003694 and talazoparib, can help people with advanced solid tumors that have not responded to other treatments. Talazoparib is a type of drug that targets cancer cells with certain DNA repair problems. The study is divided into groups based on specific gene mutations or previous treatment responses.
Duarte, CaliforniaAges 18 years+ - NCT06751329RecruitingPhase 1/Phase 2
Study of DM002 for advanced solid tumors
This trial tests a new drug called DM002 for people with advanced solid tumors that have not responded to standard treatments. The drug targets two proteins (MUC1 and HER3) found on some cancer cells, and may help shrink tumors or slow their growth.
San Francisco, CaliforniaAges 18 years+ - NCT06022965Recruiting
Telemedicine support for older adults with cancer
This study uses telemedicine (video or phone visits) to help older adults with cancer, especially those in underserved communities, get better care. If you're 65 or older and starting a new cancer treatment, you may be able to join from home in English, Spanish, or Chinese.
Lancaster, CaliforniaAges 65 years+ - NCT07184294Recruiting
Massage therapy for anxiety during chemo
This study tests different types of massage therapy to see if they can help reduce anxiety while you are getting chemotherapy. It is for people who have already had at least one chemo session, feel anxious, and have at least six more infusions scheduled.
Irvine, CaliforniaAges 18 years+ - NCT06410209RecruitingPhase 2
Walking Juntos: Smartphone program to help Hispanic cancer survivors be active
This study will test if a smartphone program and social media group can help Hispanic/Latino teens and young adults who had childhood cancer become more physically active. You would wear a Fitbit and use a phone app with culturally tailored tips and support.
Downey, CaliforniaAges 15–20 - NCT04871542Recruiting
Predicting risk of immune therapy side effects
This study tries to predict who is more likely to get serious side effects from immune checkpoint medicines used for solid tumors. You may help researchers by answering questionnaires before treatment and during follow-up, and by possibly storing sample specimens.
Antioch, CaliforniaAges 18 years+ - NCT06620302RecruitingPhase 1/Phase 2
Adding DT2216 to chemo for relapsed solid tumors and FLC
This trial is testing whether adding a new drug, DT2216, to standard chemotherapy can help treat solid tumors (not starting in the brain) or fibrolamellar carcinoma (FLC) that have come back or not responded to treatment. It's for children, teens, and young adults (ages 1 to 39).
Orange, CaliforniaAges 1–39 - NCT05772130Recruiting
Help family members get cancer genetic test results and counseling
This study tests a family-centered way to share cancer genetic testing results with close relatives, so more relatives get genetic counseling and testing. It may help your eligible family members understand their risk and get the right next steps.
Duarte, CaliforniaAges 18 years+ - NCT06126276RecruitingPhase 2
Testing neratinib with or without palbociclib for HER2+ solid tumors
This trial tests two targeted drugs—neratinib alone or with palbociclib—for people with HER2-positive solid tumors (other than breast cancer) that have returned or not gone away. The goal is to see if blocking HER2 and CDK4/6 can shrink or slow the tumor.
Encinitas, CaliforniaAges 18 years+ - NCT07220447RecruitingEarly Phase 1
L-Theanine for relaxation and mood in cancer survivors
This trial tests whether a natural supplement called L-theanine, found in green tea, can help cancer survivors feel more relaxed and improve their mood. You may qualify if you have finished cancer treatment, have been in surveillance for at least 6 months, and feel anxious.
Irvine, CaliforniaAges 18 years+ - NCT07306338Recruiting
Integrative oncology program interest survey at USC Norris
This trial asks patients about their interest in an integrative oncology program combining standard cancer care with complementary therapies like nutrition or acupuncture to improve well-being.
Los Angeles, CaliforniaAges 18 years+ - NCT06513962RecruitingPhase 3
Triptorelin to protect ovaries in young women with cancer
This study tests whether a medicine called triptorelin can protect the ovaries in young women and teens receiving strong chemotherapy for cancer. If you are newly diagnosed with a cancer (other than breast cancer) and are about to get certain chemotherapy drugs, this trial may help preserve your fertility.
Duarte, CaliforniaAges Up to 39 years - NCT06500377Recruiting
Comparing meditation types for relaxation in cancer survivors
This study compares four different meditation practices to see which one helps cancer survivors relax best. If you are a cancer survivor who has not had chemotherapy or radiation, you may be able to join.
Irvine, CaliforniaAges 18 years+ - NCT07412002Recruiting
End-of-life care quality for children with cancer
This trial asks bereaved parents about the quality of care their child received in the last month of life. It aims to improve how hospitals support families when a child with cancer is dying.
Oakland, CaliforniaAges 18 years+ - NCT07332312Recruiting
Cancer support program for American Indian and Alaska Native patients in rural California
This study tests a culturally informed patient navigation program designed to help American Indian and Alaska Native cancer patients reduce delays between diagnosis and treatment. It offers support through community advisors, focus groups, and a navigation program tailored to patients living in the Toiyabe Indian Health Program service area.
Bishop, CaliforniaAges Any age - NCT05334069Recruiting
Blood test study for early cancer detection in patients
This study collects blood from people with cancer and people without cancer (or with possible cancer) to test whether new blood tests can detect cancer earlier. Your blood samples help researchers evaluate how well these tests work.
Arroyo Grande, CaliforniaAges 40–75 - NCT05564377RecruitingPhase 2
Find targeted cancer treatments using genetic testing
This study matches people with advanced solid tumors to targeted treatment plans based on genetic testing. It also requires tumor sample testing to help doctors choose the most promising therapy for your specific tumor changes.
Arroyo Grande, CaliforniaAges Any age - NCT05687110RecruitingPhase 1
Testing novobiocin for tumors with DNA repair gene changes
This Phase 1 study tests whether novobiocin is safe and finds the best dose for people whose tumors have specific DNA repair gene mutations. It may help if your cancer is hard to treat with standard options, including certain patients who already tried PARP inhibitors.
Duarte, CaliforniaAges 18 years+ - NCT05227326RecruitingPhase 1
A new drug for solid cancers that did not respond to usual care
This early-stage (Phase 1) trial tests AOH1996 in adults with solid tumors that have stopped responding to standard treatments. It’s meant to find a safe dose and see if the drug can help, especially in cancers with limited options.
Duarte, CaliforniaAges 18 years+ - NCT05372614RecruitingPhase 1
Testing trastuzumab deruxtecan and neratinib for HER2-positive cancers
This trial tests a combination of two targeted drugs, trastuzumab deruxtecan (Enhertu) and neratinib, for people with solid tumors that have a HER2 gene change. The goal is to see if the combination is safe and works well for cancers that have not responded to at least one prior treatment.
Duarte, CaliforniaAges 18 years+ - NCT07235501Recruiting
Studying immune cells in chronic GVHD after stem cell transplant
This study looks at immune cells in the blood and tissues of people who have had a stem cell transplant. It aims to understand chronic graft-versus-host disease (GVHD), a common complication, so doctors can better detect and treat it.
Duarte, CaliforniaAges 7 years+ - NCT07189195RecruitingPhase 1
TR-002 for advanced solid tumors and pancreatic cancer
This trial tests a new drug called TR-002 in people with advanced solid tumors (cancer that has spread) who have run out of standard treatment options. It includes a specific group for people with pancreatic cancer that is no longer responding to chemotherapy.
Sacramento, CaliforniaAges 18 years+
Malignant Solid Neoplasm trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting malignant solid neoplasm studies listed above.
- City of Hope Comprehensive Cancer Center · 12 studies
- City of Hope Orange County Lennar Foundation Cancer Center · 5 studies
- UC San Diego Medical Center · 5 studies
- UC San Diego Moores Cancer Center · 5 studies
- USC / Norris Comprehensive Cancer Center · 5 studies
- Kaiser Permanente-Oakland · 4 studies
- University of California Davis Comprehensive Cancer Center · 4 studies
- University of California, San Francisco · 4 studies
What taking part in a malignant solid neoplasm study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Malignant Solid Neoplasm trials in other states
Common questions
- Are there malignant solid neoplasm clinical trials in California?
- Yes. We're currently tracking 75 recruiting malignant solid neoplasm studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a malignant solid neoplasm study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a malignant solid neoplasm trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New malignant solid neoplasm studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.