Clinical trials
Mental Health (Depression) clinical trials
Below are recruiting mental health (depression) clinical trials, each written for real people, not researchers. We’re tracking 315 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04639830Recruiting
Testing how sleep patterns relate to child brain development
This study looks at how a child’s sleep looks on a sleep-monitoring test and how that relates to brain/learning growth over time. It includes some children without known risks and some children with known developmental or learning risks, to better understand sleep’s role.
Bethesda, MarylandAges 6 months–8 years - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT06457230Recruiting
Brain stimulation for methamphetamine use disorder
This study tests a new type of non-invasive brain stimulation (transcranial magnetic stimulation) that targets the cerebellum and prefrontal cortex to help people with methamphetamine use disorder. It aims to see if this treatment can reduce cravings and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT06468046Recruiting
Empowered Mom: A mental health program for migrant mothers
This study tests a new program called 'Mama Empoderada' (Empowered Mom) to help prevent depression and anxiety in migrant mothers who have young children. If you join, you'll learn skills to support your mental health and bond with your child.
Tijuana, Estado de Baja CaliforniaAges 18–99 - NCT05887934Enrolling by invitation
Bone lead levels and mental health in adults
This study looks at whether the amount of lead stored in the body (from old exposures) is linked to brain activity and mental health. It may help researchers understand what kinds of brain/mental health symptoms are related to lead exposure.
Charleston, South CarolinaAges 18–70 - NCT07395752Recruiting
Youth suicide prevention program with brain imaging study
This study tests a new program to help young people who have hurt themselves or tried to end their life. It uses brain scans (MRI) to understand how the program works and why it might help.
Suwon, Gyeonggi-doAges 15–30 - NCT07173608Recruiting
Meditation and thinking skills for teen mental health
This study tests whether learning meditation and a thinking skill called cognitive reappraisal (changing how you think about a situation) can help teens feel better and handle stress. It is for teens aged 15-18 who live in the US and can visit a hospital in Boston.
Boston, MassachusettsAges 15–18 - NCT06711666Recruiting
Maternal mental health and baby's brain in heart disease
This study looks at how a mother's mental health during pregnancy may affect the brain development of babies with a serious heart condition called critical cyanotic congenital heart disease (CHD). It aims to understand this link to improve support for families.
MarseilleAges Up to 50 years - NCT03304665Recruiting
Healthy volunteers needed for brain and behavior research studies
This study recruits healthy adults to help researchers run mental health and brain-related experiments. It may help future studies by improving how they measure brain function and behavior.
Bethesda, MarylandAges 18–70 - NCT04373629Recruiting
Testing how flexible appearance worries may change in BDD
This study looks at whether training can change how people with body appearance worries (including body dysmorphic disorder) perceive faces or the head. It may help researchers understand new ways to reduce distress related to these concerns.
Toronto, OntarioAges 18–40 - NCT04539951RecruitingPhase 2
Trial for newly treated obsessive-compulsive disorder
This phase 2 study tests an OCD treatment strategy for people who have not yet had OCD medications or recent OCD therapy. It aims to reduce OCD symptoms, especially for those with moderate-to-severe symptom levels.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT05012072Recruiting
Lifestyle coaching to lower pregnancy stress and risk
This study tests a lifestyle coaching program to help reduce stress and improve emotional wellbeing during pregnancy. It may help lower risks for the baby by supporting healthier daily routines and mental health.
Webster, TexasAges 18–45 - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Holyoke, MassachusettsAges 18 years+ - NCT05666726Recruiting
Study how stress and body feelings affect choices
This study tests how changes in your internal body feelings (like heart rate and awareness of bodily sensations) and stress can affect decision-making and self-reflection. It may help researchers understand how thoughts, feelings, and body signals connect—especially in people vulnerable to anxiety or depression.
Bethesda, MarylandAges 18–55 - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT05748990Recruiting
Brain insulin differences in schizophrenia and thinking
This study tests whether unusual insulin action in the brain is linked to thinking problems and body/metabolic issues in schizophrenia. It may help researchers understand the cause and identify targets for future treatments.
Toronto, OntarioAges 17–45 - NCT06129903Recruiting
Early psychiatric help for people with sarcoma
This study tests if getting a psychiatric consultation soon after a sarcoma diagnosis can improve mental health and quality of life. If you have a new sarcoma and need surgery at MSK, you may be able to join.
Basking Ridge, New JerseyAges 18 years+ - NCT06163599Recruiting
Telenovela for anxiety in Latinx adults
This trial tests if a telenovela-style video can help reduce anxiety symptoms in Spanish-speaking Latinx adults. You may be eligible if you have mild to moderate anxiety and want to participate from home using your smartphone.
Reno, NevadaAges 18 years+ - NCT06247306Recruiting
Neurofeedback and stress in alcohol use
This study uses a brain-training technique called neurofeedback to help understand how stress and drinking are linked. You would use your smartphone to participate, and the goal is to find better ways to manage alcohol use.
Mannheim, Baden-WurttembergAges 18–65 - NCT06348992Recruiting
Talk therapy and yoga for burnout in parents of children with autism
This study tests if combining talk therapy (ACT) with gentle yoga can help parents of children with autism who feel burned out. If you often feel exhausted or overwhelmed by caregiving, this program may give you new coping skills and support.
Daqing, None SelectedAges Any age - NCT06351514RecruitingPhase 3
Accelerated brain stimulation for negative symptoms of schizophrenia
This trial tests a faster form of brain stimulation called accelerated intermittent theta burst stimulation to help with persistent negative symptoms of schizophrenia. Negative symptoms include things like lack of motivation, reduced emotion, or social withdrawal.
SingaporeAges 21–65 - NCT06466057Recruiting
Metacognitive therapy for obsessive-compulsive disorder
This study tests a type of talk therapy called metacognitive therapy for people with obsessive-compulsive disorder (OCD). The goal is to see if it helps reduce OCD symptoms by changing how you think about your thoughts.
Changchun, JilinAges 12–60 - NCT06486688Recruiting
Virtual program to help teens with substance use risk
This trial tests a virtual program integrated into pediatric check-ups to help teens at risk for alcohol or drug problems. It aims to identify teens who may need extra support and connect them with helpful resources.
Pleasanton, CaliforniaAges 12–17 - NCT06505226Recruiting
Music mindfulness study for anxiety and depression
This study tests a music-based mindfulness program to help people with anxiety or depression. It compares the program to a wait list to see if it eases symptoms.
New Haven, ConnecticutAges 18–65
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Common questions
- Are there clinical trials for mental health (depression)?
- Yes. Clin2 currently lists 315 recruiting mental health (depression) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health (depression) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health (depression) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.