Clinical trials
Mental Health (Depression) clinical trials
Below are recruiting mental health (depression) clinical trials, each written for real people, not researchers. We’re tracking 315 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07673380RecruitingPhase 2
Mobile health for opioid recovery and mental health
This study uses a mobile health app to help Black and African American individuals recover from opioid or stimulant use and improve mental health. It aims to see if the app can support treatment and well-being.
St Louis, MissouriAges 18 years+ - NCT07118072Recruiting
Online therapy for childhood trauma and depression symptoms
This study will test if a special online therapy program, called i-STAIR, can help people who had a tough childhood and are now dealing with some depression symptoms. It focuses on building skills to manage emotions and relationships, all from the comfort of your home.
SingaporeAges 21–65 - NCT06780917Recruiting
Online cognitive testing for older adults with depression or memory concerns
This study tests whether an online cognitive assessment platform (Creyos) is valid for older adults with major depression or mild cognitive impairment. Participants will complete brain games or puzzles to see how well the online tool measures thinking skills.
Toronto, OntarioAges 60 years+ - NCT07717723Recruiting
Support for caregivers of heart disease patients
This study tests a program to help caregivers of people with heart disease manage stress and challenges. It aims to support your mental health while caring for a loved one.
Sacramento, CaliforniaAges 18 years+ - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT03065335RecruitingPhase 1
Ketamine plus brain imaging to study response in depression
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Bethesda, MarylandAges 18–65 - NCT04972136Recruiting
Brain stimulation treatment for depression in young adults with autism
This trial studies a noninvasive brain stimulation (rTMS) to help reduce depression symptoms in young adults who have autism. It aims to find out if this treatment can improve mood and daily functioning without requiring recent changes to medications.
Toronto, OntarioAges 16–35 - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT07107906Recruiting
CONNECT program: group telehealth to reduce loneliness in adults 55+
This trial tests a group-based telehealth program called CONNECT, which aims to reduce loneliness, social isolation, and mental health symptoms like anxiety or depression in adults aged 55 and older. You'll join online group sessions instead of in-person programs, making it easier to connect from home.
Winnipeg, ManitobaAges 55 years+ - NCT06732128Recruiting
Nature virtual reality for depression in Alzheimer's disease
This trial tests whether a virtual reality nature experience can help improve mood in people with early-to-moderate Alzheimer's disease. Participants will use a VR headset and a few apps at home, with a caregiver present, over several sessions.
Toronto, OntarioAges 50 years+ - NCT06828276Recruiting
Online therapy for Farsi and Dari speaking young migrants
This study tests if a culturally adapted online therapy program helps reduce anxiety and depression in young Farsi or Dari speaking migrants. You would use your computer or phone for 6 to 10 weeks at home.
StockholmAges 15–29 - NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06005103Recruiting
Testing a headband that sends brain pulses for depression
This study tests a new headband that sends gentle electrical pulses to the brain (T-PEMF) to lift depression. You might join if you have moderate to severe depression and don't have certain other conditions or implants.
Frederiksberg, Capital RegionAges 18–65 - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT02543983RecruitingPhase 2
Brain scan and ketamine study for suicidal thoughts
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Bethesda, MarylandAges 18–70 - NCT06385405Recruiting
Brain stimulation for depression using EEG guidance
This trial uses a brain scan technique (EEG) to guide a treatment called repetitive transcranial magnetic stimulation (rTMS) for people with major depressive disorder. It aims to see if personalizing the treatment based on brain activity can help improve depression symptoms.
Shanghai, Shanghai MunicipalityAges 16–65 - NCT07404085Recruiting
Cognitive training with medication for mood disorders
This trial tests if a medication can boost the effects of cognitive training in people with bipolar disorder or recurrent depression who have memory or thinking problems. It aims to improve daily functioning.
Frederiksberg, Capital Region of DenmarkAges 40–75 - NCT07055061Recruiting
Music for reducing stress, anxiety and depression
This trial tests if listening to specially designed music can help reduce stress, anxiety and depression. It may be a good option for people who are not currently taking medication or receiving treatment.
Beijing, Beijing MunicipalityAges 18–60 - NCT06233344RecruitingPhase 2
Mindfulness and psilocybin study for healthy adults
This study tests whether combining mindfulness training with a single dose of psilocybin (a psychedelic found in certain mushrooms) can help healthy adults. It aims to explore how these two approaches together might improve well-being.
Los Angeles, CaliforniaAges 25 years+ - NCT06208358Recruiting
Testing brain stimulation for gaming disorder
This study tests if a gentle brain stimulation technique (tACS) can help people with severe gaming disorder by improving how they interact with others. It aims to understand and treat the social challenges linked to the condition.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT05766592RecruitingPhase 3
Therapy for sexual or gender-minority adults and a rejecting parent
This study tests a therapy program tailored for sexual and gender-minority adults who are dealing with strong rejection from a parent. It also involves that parent in sessions to help improve support and reduce anxiety or depression.
New York, New YorkAges 20 years+ - NCT05525676Recruiting
Couple check-ins to help reduce suicide risk
This study tests whether scheduled relationship check-ins for couples can lower mental distress and suicide risk for at least one partner. It focuses on couples where someone is a Veteran and has positive screening signs like low mood, post-traumatic stress, unsafe drinking, or suicidal thoughts.
Canandaigua, New YorkAges 18 years+
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Common questions
- Are there clinical trials for mental health (depression)?
- Yes. Clin2 currently lists 315 recruiting mental health (depression) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health (depression) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health (depression) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.