Clinical trials
Mental Illness clinical trials
Below are recruiting mental illness clinical trials, each written for real people, not researchers. We’re tracking 65 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05674617Recruiting
PTSD treatment for Veterans with serious mental illness
This trial tests a PTSD treatment approach for Veterans who also have a serious mental illness, aiming to improve day-to-day functioning. It includes Veterans who receive outpatient mental health care through the VA and have confirmed PTSD in the last month.
Baltimore, MarylandAges 18 years+ - NCT06674616Enrolling by invitation
Heart health program for community mental health staff
This trial tests a program to improve heart health in community mental health settings. Staff members will be trained to deliver the program and help reduce health disparities.
Baltimore, MarylandAges 18 years+ - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT07528261Recruiting
Support Group for Family Caregivers of Stroke Survivors
This study tests whether a support group using acceptance and commitment therapy (a type of counseling that helps people cope with stress) can reduce caregiver burden and distress. You would meet online with other people caring for stroke survivors.
Alameda, CaliforniaAges 40 years+ - NCT05776316Recruiting
Harm-reduction support for adults using opioids
This trial offers harm-reduction services for adults who have been misusing opioids (and sometimes other substances) recently. It’s designed to test support approaches that may reduce risks and improve well-being.
New Haven, ConnecticutAges 18 years+ - NCT04940663RecruitingTeam says not enrolling
Study brain and feelings in loneliness and social isolation
This study looks at how the brain and behavior relate to loneliness and feeling socially isolated in people with serious mental health conditions. It may help researchers understand what drives loneliness and how it could be addressed in the future.
Charlestown, MassachusettsAges 18–55 - NCT06203509Recruiting
Helping after a hospital stay for serious mental illness
This study helps people with serious mental illness who are on Medicaid, living in Pennsylvania, and recently left the hospital. It offers extra support and care in your home to make the transition smoother.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT06781801Recruiting
Heart and metabolic health for severe mental illness
This trial tests a long-term program to improve heart and metabolic health in adults with schizophrenia or related disorders. It may help reduce health risks often linked with severe mental illness.
GothenburgAges 18 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT07529509Recruiting
Mental Health Support for Latino Adults in Connecticut
This study helps Latino adults in Connecticut who have serious mental health challenges and trauma but aren't currently in treatment. Researchers want to understand how to better engage and support this community.
New Haven, ConnecticutAges 18 years+ - NCT07106385Recruiting
rTMS for better sleep in healthy adults
This study tests if a non-invasive brain stimulation method called rTMS can help improve sleep in adults who are generally healthy but have sleep complaints. If you are 18–65 and often have trouble sleeping, this might be a way to try a new approach without medication.
Hong Kong, Pok Fu LamAges 18–65 - NCT07106398Recruiting
Can brain stimulation reduce food cravings and help weight control?
This study tests whether a non-invasive brain stimulation technique called rTMS can help reduce food cravings and support weight control in adults who struggle with these issues but are otherwise healthy.
Hong Kong, Pok Fu LamAges 18–65 - NCT06951542Enrolling by invitation
Reducing HIV and mental health stigma in Malawi
This study tests a program to reduce stigma for people living with HIV who also have symptoms of depression. It aims to improve mental health and HIV outcomes.
MulanjeAges 18 years+ - NCT06940843Recruiting
Hopeful and Healthy Living program study
This study tests a program called Hopeful and Healthy Living to see if it helps people with serious mental illness feel better and live healthier. It's for adults 50 and older who are part of specific support programs in Boston.
Boston, MassachusettsAges 50 years+ - NCT06370767Recruiting
Peer-assisted transportation study for adults with mental illness
This trial tests whether working with a peer helper can help adults with serious mental illness learn to use bikeshare and public transportation. You'll get support to travel more independently.
Philadelphia, PennsylvaniaAges 18–65 - NCT07730307Recruiting
Study on sharing suicidal thoughts and getting support
This study looks at how people share their experiences with suicidal thoughts or severe depression and what happens when they seek support. It aims to help understand the risks and benefits of talking about these struggles.
Mpunde, Buyende DistrictAges 18 years+ - NCT04366531Recruiting
START-VETS support after prison for veterans
This study is looking at tools to help veterans who recently left prison successfully transition back into everyday life, especially when they have mental health and/or substance use concerns. It may help by teaching practical support and coping strategies during reintegration.
Dallas, TexasAges 18 years+ - NCT05157620Recruiting
Yoga and exercise program for veterans with severe mental illness
This trial tests an exercise and yoga-style wellness program to help veterans with severe mental health conditions feel and function better. It may help with symptoms and overall well-being, especially if your condition is currently stable.
Pittsburgh, PennsylvaniaAges 18–70 - NCT05491538Recruiting
Work skills training for Veterans living with serious mental illness
This study tests whether a social-skills training program designed for work goals is doable and helpful for Veterans with serious mental illness. It focuses on improving work-related coping and interactions while you receive supported services through the VA.
Minneapolis, MinnesotaAges 18 years+ - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT05703711Recruiting
MHealth plus nurse care for mental health in West Africa
This trial tests whether combining phone-based support (mHealth) with regular nurse-delivered care can improve outcomes for people with serious mental illness. You might benefit if you’re currently in an inpatient prayer camp and living with psychosis, mania, or depression.
AccraAges 18 years+ - NCT05829408Recruiting
Support for parents from your own family and friends
This trial looks at a support approach that involves your existing “circle” of family and friends. It may help parents who are struggling in how they manage key caregiving tasks so children are less likely to have to take on those responsibilities.
GroningenAges Any age - NCT05962879Recruiting
Program for teens with early psychosis-like experiences
This trial tests a new mental health program for teenagers who are having at least one psychosis-like experience and may be at risk for serious mental illness. It may help by offering structured support for both teens and their parents.
Boston, MassachusettsAges 14–19
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Common questions
- Are there clinical trials for mental illness?
- Yes. Clin2 currently lists 65 recruiting mental illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.