Clinical trials
Serious Mental Illness clinical trials
Below are recruiting serious mental illness clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06859060Recruiting
Improving health for people with serious mental illness
This study helps people with serious mental illness like schizophrenia or bipolar disorder who also have chronic health conditions (e.g., diabetes, overweight) get better overall care. It focuses on improving health and wellness through preventive medical care in Puerto Rico.
Mayagüez, Puerto RicoAges 21 years+ - NCT07006935Recruiting
Clubhouse program effects on recovery and brain health
This study looks at how Clubhouse programs (a type of community-based support) affect thinking and brain health in people with schizophrenia or related conditions. It compares Clubhouse participation to usual care. If eligible, you would complete thinking tests and possibly an MRI brain scan.
Cleveland, OhioAges 18–50 - NCT05807867Recruiting
Support program to help women with HIV keep treatment working
This study tests a stigma-reducing support program to help women living with HIV and serious mental illness stay adherent to HIV treatment. It focuses on sustaining viral suppression by addressing stigma that can make care harder, and it involves family and community leaders as part of the approach.
GaboroneAges 18–65 - NCT06586164Recruiting
Rehabilitation research for veterans with serious mental illness
This study is testing a new rehabilitation program for veterans with serious mental illness, like schizophrenia, bipolar disorder, or PTSD. If you join, you will help researchers see if this program improves daily functioning and quality of life.
San Diego, CaliforniaAges 18–83 - NCT06865937Recruiting
A mobile app to help with social recovery in serious mental illness
This study tests a mobile app that provides support for social recovery in people with serious mental illness. It may help you feel less isolated and more connected.
San Diego, CaliforniaAges 18–65 - NCT06880796Enrolling by invitation
Mindfulness therapy for serious mental illness
This trial tests whether mindfulness-based therapy helps people with serious mental illnesses like schizophrenia or mood disorders. You'll learn mindfulness skills in a group setting at your community mental health center.
Providence, Rhode IslandAges 18 years+ - NCT06674616Enrolling by invitation
Heart health program for community mental health staff
This trial tests a program to improve heart health in community mental health settings. Staff members will be trained to deliver the program and help reduce health disparities.
Baltimore, MarylandAges 18 years+ - NCT05674617Recruiting
PTSD treatment for Veterans with serious mental illness
This trial tests a PTSD treatment approach for Veterans who also have a serious mental illness, aiming to improve day-to-day functioning. It includes Veterans who receive outpatient mental health care through the VA and have confirmed PTSD in the last month.
Baltimore, MarylandAges 18 years+ - NCT04940663RecruitingTeam says not enrolling
Study brain and feelings in loneliness and social isolation
This study looks at how the brain and behavior relate to loneliness and feeling socially isolated in people with serious mental health conditions. It may help researchers understand what drives loneliness and how it could be addressed in the future.
Charlestown, MassachusettsAges 18–55 - NCT06203509Recruiting
Helping after a hospital stay for serious mental illness
This study helps people with serious mental illness who are on Medicaid, living in Pennsylvania, and recently left the hospital. It offers extra support and care in your home to make the transition smoother.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT07529509Recruiting
Mental Health Support for Latino Adults in Connecticut
This study helps Latino adults in Connecticut who have serious mental health challenges and trauma but aren't currently in treatment. Researchers want to understand how to better engage and support this community.
New Haven, ConnecticutAges 18 years+ - NCT07106385Recruiting
rTMS for better sleep in healthy adults
This study tests if a non-invasive brain stimulation method called rTMS can help improve sleep in adults who are generally healthy but have sleep complaints. If you are 18–65 and often have trouble sleeping, this might be a way to try a new approach without medication.
Hong Kong, Pok Fu LamAges 18–65 - NCT07106398Recruiting
Can brain stimulation reduce food cravings and help weight control?
This study tests whether a non-invasive brain stimulation technique called rTMS can help reduce food cravings and support weight control in adults who struggle with these issues but are otherwise healthy.
Hong Kong, Pok Fu LamAges 18–65 - NCT06940843Recruiting
Hopeful and Healthy Living program study
This study tests a program called Hopeful and Healthy Living to see if it helps people with serious mental illness feel better and live healthier. It's for adults 50 and older who are part of specific support programs in Boston.
Boston, MassachusettsAges 50 years+ - NCT06370767Recruiting
Peer-assisted transportation study for adults with mental illness
This trial tests whether working with a peer helper can help adults with serious mental illness learn to use bikeshare and public transportation. You'll get support to travel more independently.
Philadelphia, PennsylvaniaAges 18–65 - NCT05491538Recruiting
Work skills training for Veterans living with serious mental illness
This study tests whether a social-skills training program designed for work goals is doable and helpful for Veterans with serious mental illness. It focuses on improving work-related coping and interactions while you receive supported services through the VA.
Minneapolis, MinnesotaAges 18 years+ - NCT05703711Recruiting
MHealth plus nurse care for mental health in West Africa
This trial tests whether combining phone-based support (mHealth) with regular nurse-delivered care can improve outcomes for people with serious mental illness. You might benefit if you’re currently in an inpatient prayer camp and living with psychosis, mania, or depression.
AccraAges 18 years+ - NCT05962879Recruiting
Program for teens with early psychosis-like experiences
This trial tests a new mental health program for teenagers who are having at least one psychosis-like experience and may be at risk for serious mental illness. It may help by offering structured support for both teens and their parents.
Boston, MassachusettsAges 14–19 - NCT05537376Recruiting
Peer-led suicide prevention support for veterans with serious mental illness
This study tests a suicide-prevention program delivered by trained peer specialists (other people with similar lived experience) to help veterans who are currently having suicidal thoughts. It aims to add ongoing support and improve safety and recovery for veterans with serious mental health conditions.
San Diego, CaliforniaAges 18 years+ - NCT06641726Recruiting
Global database linking genetics and health records for mental illness
This trial is building a research database that combines genetic information and long-term health data to improve personalized treatment for serious mental illness. You may be eligible if you have been diagnosed or treated for depression, bipolar disorder, schizophrenia, or dementia.
Oxford, OxfordAges 18–110 - NCT07264062Enrolling by invitation
MetSense pilot study for serious mental illness
This pilot study is testing a program for people with serious mental illness like schizophrenia or bipolar disorder. It aims to see if adding a special monitoring tool helps manage treatment better.
Pleasanton, CaliforniaAges 18 years+ - NCT07339462Recruiting
Support program for mental illness recovery in South Africa
This study tests a new support program for people with serious mental illness (like schizophrenia or bipolar with psychosis) after a hospital stay. It includes their caregiver and focuses on helping them adjust to life back in the community.
Pietermaritzburg, KwaZulu-NatalAges 18 years+
Hear when a new Serious Mental Illness trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Serious Mental Illness trials by city
Studies with a site in or near these metro areas.
Common questions
- Are there clinical trials for serious mental illness?
- Yes. Clin2 currently lists 29 recruiting serious mental illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a serious mental illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a serious mental illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.