Clinical trials
Severe Mental Illness clinical trials
Below are recruiting severe mental illness clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07549178Recruiting
Mobile monitoring and care coordination for serious mental illness
This study tests whether combining extra care coordination with tracking data from your smartphone can help improve mental health care and reduce hospital visits. Researchers will use your smartphone to monitor your wellbeing while a care coordinator helps connect you with the support you need.
West Los Angeles, CaliforniaAges 18 years+ - NCT04881084Recruiting
Digital stories to explore empathy and compassion
This study uses digital narratives (digital storytelling) to see how they may affect empathy and compassion. You may be asked to participate if you’re not currently in the hospital and haven’t already taken part in a specific prior workshop.
Montreal, QuebecAges 18–35 - NCT05432089RecruitingPhase 2
Oxytocin and therapist-client syncing during inpatient care
This Phase 2 study tests whether giving oxytocin (a hormone sometimes studied for social and bonding effects) helps patients and therapists become more “physiologically synchronized” during inpatient psychiatric care. It compares responses in patients and therapists to see if this change is measurable and potentially helpful.
Hod HaSharonAges 18–80 - NCT05533749Recruiting
E-Health coaching to improve health habits in severe mental illness
This study tests an online (eHealth) program to help people with severe mental illness improve physical health and everyday lifestyle behaviors. If you’re eligible, you’ll be asked to use the internet program and complete questionnaires.
The Hague, South HollandAges 18–65 - NCT06315114Recruiting
Parenting support therapy for mental health
This study tests a talking therapy that helps parents with mental health challenges to better understand and connect with their child. It is designed for parents who are already getting help for conditions like anxiety, PTSD, or personality disorders.
Gentofte Municipality, Capital RegionAges 18–65 - NCT06624462Recruiting
Meta Care Clinic for weight and health in severe mental illness
This study tests a special clinic that helps people with schizophrenia or bipolar disorder manage their weight and metabolic health while taking antipsychotic medication. It focuses on improving overall health with practical support.
Glostrup Municipality, Capital RegionAges 18–45 - NCT06659211Recruiting
Mentalization-based therapy for mental health challenges
This study tests whether mentalization-based therapy (MBT), a type of talk therapy that helps you understand your own and others' thoughts and feelings, can improve severe long-term mental health symptoms and relationship difficulties. You will be placed in either MBT or the usual care (TAU) group to compare results.
OuluAges 18–64 - NCT06743711Recruiting
Heart fitness in severe mental illness study
This study checks how fit your heart and lungs are if you have a serious mental illness like schizophrenia or bipolar disorder. It aims to see if fitness can help improve health and well-being.
Glostrup MunicipalityAges 18–45 - NCT06789250Recruiting
Online therapy for mental health and alcohol use issues
This trial tests an internet-based cognitive behavioral therapy program designed for people who struggle with both mental health symptoms (like depression or anxiety) and problematic alcohol use. The goal is to see if this approach can help improve both issues at the same time, conveniently from home.
LinköpingAges 18 years+ - NCT06914622Recruiting
Real-life recovery study for mental health
This study uses a smartphone app to track daily experiences, physical activity, and biological markers in people receiving treatment for a mental disorder. The goal is to understand how these factors relate to personal recovery.
BresciaAges 18 years+ - NCT07085923Recruiting
Heart health study for people with mental illness
This study tests a program to improve heart health in people with schizophrenia or bipolar disorder who take antipsychotic medication or lithium and have a high body weight. The goal is to help reduce heart disease risk.
OsloAges 25–70 - NCT07316803Recruiting
Group therapy for romantic relationships in young adults with mental illness
This study tests a group program to help young adults with serious mental health conditions build skills for romantic and social relationships. It may be a good fit if you are single, motivated to work on relationships, and have received mental health care recently.
Épinay-sur-Seine, Île-de-France RegionAges 18 years+ - NCT07339462Recruiting
Support program for mental illness recovery in South Africa
This study tests a new support program for people with serious mental illness (like schizophrenia or bipolar with psychosis) after a hospital stay. It includes their caregiver and focuses on helping them adjust to life back in the community.
Pietermaritzburg, KwaZulu-NatalAges 18 years+ - NCT07658547Enrolling by invitation
AI Chatbots for Mental Health
This trial tests if an AI chatbot can help people with a diagnosed mental illness. It aims to find a new way to support your mental health.
Rüdersdorf, BrandenburgAges 18 years+ - NCT07448675Enrolling by invitation
Thinking and memory in untreated severe mental illness
This study looks at how severe mental illness affects thinking and memory in people who have never been treated. It may help researchers understand the early brain changes and find better ways to help.
TianjinAges 18–65 - NCT06781801Recruiting
Heart and metabolic health for severe mental illness
This trial tests a long-term program to improve heart and metabolic health in adults with schizophrenia or related disorders. It may help reduce health risks often linked with severe mental illness.
GothenburgAges 18 years+ - NCT05157620Recruiting
Yoga and exercise program for veterans with severe mental illness
This trial tests an exercise and yoga-style wellness program to help veterans with severe mental health conditions feel and function better. It may help with symptoms and overall well-being, especially if your condition is currently stable.
Pittsburgh, PennsylvaniaAges 18–70 - NCT07360665Recruiting
Exercise program for people with psychosis on injectable meds
This trial tests a personalized exercise program for people with psychosis who take long-acting injectable antipsychotics. The goal is to see if regular physical activity can improve overall health and well-being.
Vila RealAges 18 years+ - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+ - NCT06804954Recruiting
Online CBT vs. usual care for mild mental health issues
This study tests an online CBT program (cognitive behavioral therapy you do from home) versus usual care for people with mild to moderate anxiety, depression, or stress. It aims to help you manage symptoms before they become more serious.
Gustavsberg, Stockholm CountyAges 18 years+ - NCT06904079Recruiting
AI-based rehab study for serious mental disorders
This study uses computer analysis and AI to predict how people with severe mental disorders might recover and to suggest better support. It may help improve rehabilitation plans tailored to each person.
ShanghaiAges 18–65 - NCT07479758Recruiting
Brain scans and vision tests for severe mental illness
This study uses advanced MRI scans and visual perception tests to learn more about severe mental disorders like depression, schizophrenia, and bipolar disorder. It aims to improve diagnosis and treatment outcomes.
Hangzhou, ZhejiangAges 18–45 - NCT06865937Recruiting
A mobile app to help with social recovery in serious mental illness
This study tests a mobile app that provides support for social recovery in people with serious mental illness. It may help you feel less isolated and more connected.
San Diego, CaliforniaAges 18–65 - NCT07006935Recruiting
Clubhouse program effects on recovery and brain health
This study looks at how Clubhouse programs (a type of community-based support) affect thinking and brain health in people with schizophrenia or related conditions. It compares Clubhouse participation to usual care. If eligible, you would complete thinking tests and possibly an MRI brain scan.
Cleveland, OhioAges 18–50
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Common questions
- Are there clinical trials for severe mental illness?
- Yes. Clin2 currently lists 47 recruiting severe mental illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.