Clinical trials
Methylene Blue clinical trials
Below are recruiting methylene blue clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06834087Enrolling by invitation
Laser and dye vs. nanoparticle therapy for dark gums
This trial compares two newer treatments for dark gums—laser plus a blue dye versus laser plus tiny particles that are activated by light. The goal is to see which works better and is safer.
Kafr ash Shaykh, Kafr Ash Shaikh/ ElhamrawyAges 18–50 - NCT05830630Recruiting
Methylene blue given during leg amputation surgery
This trial studies whether infusing methylene blue during above- or below-knee leg amputation can improve outcomes for people with poor blood flow to the legs. It targets patients having surgery under general anesthesia, while excluding those with certain allergies or blood clotting problems.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06481410Recruiting
Methylene blue for severe septic shock
This trial is testing whether a medication called methylene blue can help people with severe septic shock who are already on strong blood pressure support (norepinephrine). The goal is to see if it improves survival and reduces the need for other treatments.
Hangzhou, ZhejiangAges Any age - NCT07264543RecruitingPhase 2/Phase 3
Early methylene blue for blood flow in sepsis
This trial tests if giving methylene blue early can improve blood flow in patients with sepsis who still have low blood pressure despite fluids and are on high doses of noradrenaline. It aims to help stabilize their condition.
Curitiba, ParanáAges 18 years+ - NCT06887036RecruitingPhase 2
Methylene blue for chronic inactive hepatitis B
This trial tests whether a medication called methylene blue can help lower the amount of hepatitis B virus in people with a chronic but inactive infection. It may be an option for people whose virus levels are stable but not fully controlled.
Lugano, Canton TicinoAges 18–79 - NCT07324954RecruitingPhase 1
Methylene blue for knee replacement surgery
This study tests if using a blue dye called methylene blue during knee replacement surgery can help doctors see and clean out infections better. It may help people having a first-time knee replacement or those with an infected knee replacement.
Miami, FloridaAges 18 years+ - NCT07169487RecruitingPhase 1
Methylene Blue for Side Effects of Cancer Immunotherapy
This trial tests if methylene blue can help people who develop side effects called CRS or ICANS after treatments like CAR-T cells or bispecific antibodies. It is a first-in-human study to find a safe dose.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06801938Recruiting
Blue dye test during incontinence surgery to reduce complications
This study tests if using a special blue dye (methylene blue) during surgery to correct stress urinary incontinence helps doctors find and prevent complications. It compares two surgical methods (TVT and TOT) to see which is safer.
IstanbulAges 18–85 - NCT07040657Recruiting
Comparing injection techniques for cervical lymph node mapping in endometrial cancer
This trial tests two different injection methods in the cervix to help map lymph nodes for endometrial cancer. The goal is to find which technique works better for staging, using a dye that helps surgeons see the lymph nodes during surgery.
AnkaraAges 18–75 - NCT06660680Enrolling by invitationPhase 3
Methylene blue for pain after hemorrhoid surgery
This trial tests whether injecting methylene blue (a dye) into the area around the anus during hemorrhoid surgery can reduce pain after the operation. If you are having Milligan-Morgan surgery for mixed hemorrhoids, this study may help find a way to make your recovery more comfortable.
Hefei, AnhuiAges 18–75 - NCT07311070Enrolling by invitationPhase 3
Methylene blue gel for skin cancer not treated by surgery or radiation
This trial tests a methylene blue gel for people with certain types of basal cell carcinoma (a common skin cancer) who cannot have surgery or radiation. The goal is to see if the gel can treat the cancer safely and effectively.
Mashhad, Razavi Khorasan ProvinceAges 18 years+ - NCT06520306Enrolling by invitation
Ropivacaine with methylene blue for hip surgery pain
This trial tests if adding different amounts of methylene blue to a standard numbing medicine (ropivacaine) can improve pain relief, thinking ability, and hip movement after hip replacement surgery.
TaizhouAges 60–85 - NCT07311057Enrolling by invitationPhase 3
Methylene Blue for Skin Cancer Not Removable by Surgery
This trial tests a new methylene blue formula injected into skin cancer tumors that cannot be removed by surgery or treated with radiation. It is for people who have one or more small tumors (each less than 2 cm) and cannot have the usual treatments.
Mashhad, Razavi Khorasan ProvinceAges 18 years+ - NCT06747195Recruiting
Methylene blue for better recovery after hemorrhoid surgery
This trial tests if adding methylene blue to standard pain medicine helps you recover faster and with less pain after hemorrhoid surgery. It is for people having spinal anesthesia.
Heze, ShandongAges 18–65 - NCT07463859Recruiting
Treating gum disease and bad breath in diabetes patients
This trial tests whether combining standard gum treatment with a light-activated therapy can reduce bad breath in people with type 2 diabetes and advanced gum disease.
Bauru, São PauloAges 18–70
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Common questions
- Are there clinical trials for methylene blue?
- Yes. Clin2 currently lists 15 recruiting methylene blue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a methylene blue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a methylene blue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.