Early methylene blue for blood flow in sepsis
Treatments studied
Part of Infections clinical trials.
This trial tests if giving methylene blue early can improve blood flow in patients with sepsis who still have low blood pressure despite fluids and are on high doses of noradrenaline. It aims to help stabilize their condition.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 years or older).
- You have sepsis and low blood pressure that doesn't improve enough with fluids, so you need increasing doses of noradrenaline to keep your blood pressure up.
- Your diagnosis of sepsis was within the last 6 hours.
- You are not pregnant or breastfeeding.
- You do not have a history of G6PD deficiency (a genetic condition affecting red blood cells).
- You are not allergic to methylene blue, phenothiazines (a class of drugs), or food dyes.
- You have not taken linezolid (an antibiotic) in the last 14 days.
- You have not taken serotonergic psychiatric medications (some antidepressants) in the last 2 weeks, or fluoxetine in the last 5 weeks.
- You have not taken MAOIs (a type of antidepressant) like rasagiline or selegiline in the last 2 weeks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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