Clinical trials
Neurodegeneration clinical trials
Below are recruiting neurodegeneration clinical trials, each written for real people, not researchers. We’re tracking 30 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05522374Recruiting
Study registry for people with suspected or confirmed NBIA
This trial is a research registry that collects information from people who have suspected or confirmed NBIA (a rare inherited brain movement/nerve condition). It helps researchers learn more about the condition and how it affects people, which may support future studies.
OttawaAges Any age - NCT06200909Recruiting
Self-Care Training for Family Caregivers
This research program teaches family caregivers practical self-care skills to help them feel less stressed and more supported while caring for a loved one with a progressive brain condition. It involves 8 online group sessions where you'll learn tools like mindfulness and gentle movement.
Toronto, OntarioAges 50–100 - NCT07498686Recruiting
Blood test for Parkinson's disease
This study is testing whether a simple blood test can help doctors better understand Parkinson's disease by looking at how a protein called alpha-synuclein behaves. It aims to find a new way to diagnose and track the disease.
Beijing, Beijing MunicipalityAges 18–95 - NCT06088355Recruiting
Comparing exercise amounts for moderate Parkinson's
This study compares two different amounts of light-to-moderate exercise to see which is better for people with moderate Parkinson's disease. It involves walking or doing similar activities at a comfortable pace, either a moderate amount or a higher volume, over several weeks.
Decatur, GeorgiaAges 40 years+ - NCT03402919Recruiting
Brain and memory study for people with thinking changes
This study looks at memory and thinking changes using questionnaires, memory testing, and brain scans. It may help researchers better understand neurodegeneration and dementia and how these problems show up over time.
Calgary, AlbertaAges 50–90 - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT04124029Recruiting
Study how mild brain injuries may relate to dementia
This study looks at how past mild traumatic brain injury may contribute to brain changes seen in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease (AD). It may help researchers understand risk and brain markers by comparing people with mild or moderate TBI, people with mild memory problems, and healthy controls.
Boston, MassachusettsAges 30–90 - NCT07224490RecruitingPhase 1
Kisspeptin test for brain function after COVID-19
This study tests how the brain's reproductive hormone system works after a COVID-19 infection using a substance called kisspeptin. It may help explain symptoms like changes in periods or hormone levels in people with long COVID.
Boston, MassachusettsAges 18–60 - NCT05402488Recruiting
Studying sleep recovery in adults with neurodegeneration
This study looks at how sleep “recovery” works in people with neurodegenerative diseases (conditions where abnormal proteins build up). It uses sleep recordings and sounds during sleep to see how sleep patterns relate to outcomes.
Zurich, Canton of ZurichAges 18 years+ - NCT05468905Recruiting
Study of aging and early thinking changes over time
This study follows adults 40+ to better understand and track changes in memory and thinking as people age. It groups people with normal thinking, subjective complaints, mild cognitive impairment, early Alzheimer’s, and vascular (blood vessel) related brain changes to find what predicts progression.
Hangzhou, ZhejiangAges 40–99 - NCT05516719Recruiting
Study tracking I2BS in Parkinson’s over time
This study follows people with Parkinson’s to see how “I2BS” changes over time using special brain scans and other tests. It may help researchers better understand Parkinson’s and improve how it’s measured in future trials.
Exeter, DevonAges 25 years+ - NCT05516732Recruiting
Testing serotonin activity in the brain in people with Parkinson’s
This study uses special scans to measure how serotonin is released in parts of the brain involved in movement in Parkinson’s disease. It may help researchers understand disease changes and the role of serotonin systems in movement problems.
Exeter, DevonAges 25–85 - NCT05633875Recruiting
MRI study to better understand worsening in multiple sclerosis
This study uses detailed imaging (mostly MRI) to look for patterns that may explain why multiple sclerosis can worsen. It may help researchers understand the biology behind neurodegeneration and improve future care.
ParisAges 18 years+ - NCT05934188Recruiting
Study how gut signals relate to brain aging and diseases
This study looks at how the gut may influence the brain in normal aging and conditions like Alzheimer’s, Parkinson’s, and multiple sclerosis. It may help researchers understand new ways to measure or treat these brain changes over time.
Venice-Lido, VeniceAges 20–90 - NCT06057909Recruiting
Brain function study in Lewy body and Alzheimer's disease
This study looks at how brain function changes over time in people with Lewy body disease or Alzheimer's. Researchers will use memory tests, MRI scans, and EEG (a painless brain-wave recording) to track these changes, and you will need a family member or friend to help report on your daily life.
Scottsdale, ArizonaAges 50–95 - NCT06167369Recruiting
Sleep apnea, brain health, and CPAP therapy study
This study looks at how sleep apnea affects your brain and thinking skills. Researchers want to see if CPAP treatment can help protect your brain health.
Dresden, SaxonyAges 18 years+ - NCT07657520Recruiting
High-Altitude Brain Health Study
This study follows healthy Han Chinese adults living at high altitudes to see how the brain changes over time. It may help learn why some people develop Parkinson's disease or other movement problems.
Chengdu, SichuanAges 40–75 - NCT06551649Recruiting
Test of cell-based treatment for ALS and MS
This study tests a therapy made from human amniotic cells to help reduce brain inflammation and damage. It may be an option for people with ALS or multiple sclerosis who meet the age and health requirements, as well as healthy volunteers to serve as a comparison group.
RomaAges 20–60 - NCT06582472Recruiting
Early eye changes and diabetes trial
This study looks at early damage to the retina (the back of the eye) in people with type 2 diabetes, even before vision problems start. It aims to find new ways to detect and treat diabetic eye disease early.
Milan, Italy/milanAges 40–80 - NCT06596746Recruiting
Tracking markers for neurodegenerative diseases
This study tracks changes in people with Parkinson's disease, other movement disorders, or cognitive decline to find better ways to measure disease progression.
Cassino, FrosinoneAges 10 years+ - NCT06690983Recruiting
Tau PET/CT scan study for people with related diseases
This study uses a special scan (Tau PET/CT) to look at tau protein in the brain or body. It may help doctors understand tau-related diseases better, and is open to adults who are scheduled for this scan.
Hefei, AnhuiAges 18–80 - NCT06823752RecruitingPhase 2
Insomnia medication to reduce brain damage markers in adults
This trial tests whether a medication that blocks brain chemicals involved in wakefulness can help reduce markers of nerve damage in people with insomnia. It is for adults aged 40–65 with chronic insomnia, and it aims to see if improving sleep may protect brain health.
Macquarie Park, New South WalesAges 40–65 - NCT07187843Recruiting
Parkinson's type study: brain-first vs body-first
This study looks at how Parkinson's disease affects thinking, movement, and brain health differently depending on whether it starts in the brain or the body first. Participants will have tests and scans to track these differences over time.
Reggio EmiliaAges 18 years+ - NCT07202494Recruiting
Brain aging and resilience MRI study
This study uses powerful MRI scans to understand how the brain ages and why some people stay healthy while others develop neurological diseases like multiple sclerosis or Alzheimer's. It compares healthy volunteers to people with certain conditions, and all participants get a detailed brain MRI.
MarseilleAges 18–90
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Common questions
- Are there clinical trials for neurodegeneration?
- Yes. Clin2 currently lists 30 recruiting neurodegeneration studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neurodegeneration trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neurodegeneration trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.