Clinical trials
Oral Cancer clinical trials
Below are recruiting oral cancer clinical trials, each written for real people, not researchers. We’re tracking 282 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02012699Recruiting
Cancer registry for people with or at risk of cancer
This trial collects health information and samples (a “cancer repository”) to help researchers study cancer and cancer risk. You may be able to join if you’ve had cancer before or if you’re at higher risk or have concerning findings.
Greenwood Village, ColoradoAges 19–110 - NCT07562100Recruiting
AI-Powered Exercise Program for Oral Cancer Patients Returning to Work
This study tests a smartphone-based exercise and wellness program designed to help people recently diagnosed with oral cancer prepare their body and mind before treatment, with the goal of helping them return to work faster and more safely. Researchers will track whether the program improves recovery and reduces healthcare costs.
TaipeiAges 20–70 - NCT07606638Enrolling by invitation
Pain Relief Options for Oral Cancer Patients
This study compares two different pain management approaches for people with oral cancer: opioid medication versus a combination of pregabalin (a nerve pain reliever) and naproxen sodium (an anti-inflammatory painkiller). The goal is to see which approach works better and is safer for controlling cancer-related pain.
Lahore, Punjab ProvinceAges 18 years+ - NCT07156227RecruitingPhase 1
Testing camonsertib with radiation for returning head and neck cancer
This study tests whether adding the drug camonsertib to radiation therapy can help people whose head and neck cancer has come back in a spot that was already treated with radiation. Camonsertib is an experimental drug that may help radiation work better.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06980038RecruitingPhase 2
Testing two immunotherapy drugs before surgery for advanced head and neck cancer
This trial tests whether adding a second immunotherapy drug (CDX-1140) to the standard immunotherapy cemiplimab before surgery is better than cemiplimab alone for people with stage III-IV head and neck cancer that can be removed with surgery.
Irvine, CaliforniaAges 18 years+ - NCT07195734RecruitingPhase 2
Adding chemo or immunotherapy before surgery for advanced head and neck cancer
This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.
Tucson, ArizonaAges 18 years+ - NCT05172245RecruitingPhase 1
Testing a new drug added to chemoradiation for head and neck cancer
This study tests whether adding a new targeted drug called ipatasertib to standard chemoradiation can improve treatment for people with locally advanced head and neck cancer. Ipatasertib may help block a protein that helps cancer grow, possibly making the standard therapy more effective.
Tampa, FloridaAges 18 years+ - NCT04809324Recruiting
Testing how best to check surgical margins in oral cancer
This trial compares two ways of checking whether all oral cancer tissue was removed during surgery by looking at the tissue edges. It may help surgeons choose the safest approach to reduce the chance of cancer coming back.
Mumbai, MaharashtraAges 18–100 - NCT05429099Recruiting
Planning study for jaw reconstruction surgery
This study helps teams plan surgery for people who need part of the lower jaw removed and rebuilt using special tissue flaps. It mainly looks at whether having specific pre-surgery CT images is possible and useful for reconstruction planning.
Vancouver, British ColumbiaAges 18 years+ - NCT05740033Recruiting
Closing the radial forearm donor site after mouth surgery
This study looks at how best to close the skin area on the forearm after surgeons take tissue to rebuild part of the mouth. If you need a radial forearm tissue reconstruction, you may be asked about outcomes afterward using English questionnaires.
Vancouver, British ColumbiaAges 18 years+ - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100 - NCT06785051Recruiting
AI physiotherapy for oral cancer patients
This study tests an AI-based physiotherapy program for people with newly diagnosed oral cancer. It aims to help patients maintain or improve their movement during cancer treatment, such as surgery, chemotherapy, or radiation.
TaipeiAges 20–65 - NCT07095608Recruiting
Study on nerve cells and oral cancer pain
This study looks at how certain nerve cells might be involved in oral cancer pain. It aims to find new ways to treat pain by testing tissue samples from people with oral cancer and healthy volunteers.
New York, New YorkAges 18 years+ - NCT07237672Recruiting
AI physiotherapy follow-up for oral cancer
This trial checks if an AI-based physiotherapy program helps oral cancer patients recover better. If you finished the original therapy, you can join and attend check-ups at 3 and 9 months.
TaipeiAges 20–70 - NCT02734537RecruitingPhase 2
Radiation with or without cisplatin after head and neck surgery
This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.
Birmingham, AlabamaAges 18 years+ - NCT07509619Recruiting
AI physiotherapy evaluation for oral cancer patients
This study is testing a new AI-based system that helps evaluate mouth and jaw movement (range of motion) in oral cancer patients. It enrolls healthy volunteers without any head or neck problems to gather normal movement data.
TaipeiAges 20–70 - NCT01473784Recruiting
Robot-assisted mouth and throat surgery for head and neck tumors
This trial studies using a robot-assisted operation through the mouth to diagnose or treat certain non-cancer (benign) and cancer (malignant) tumors in the head and neck. It may help some people avoid more invasive surgery by using an approach that reaches the throat and voice box area through the mouth.
Columbus, OhioAges 18 years+ - NCT07387978Recruiting
Laser therapy to prevent mouth sores during radiation for oral cancer
This trial tests if low-level laser therapy can reduce painful mouth ulcers caused by radiation treatment for oral cancer. It may help you keep your mouth healthier during therapy.
Melbourne, VictoriaAges 18 years+ - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT07602907RecruitingPhase 2
Low-dose paclitaxel with immunotherapy for advanced HER2-negative breast cancer
This trial tests a combination of low-dose oral paclitaxel (a chemotherapy pill taken regularly) plus immunotherapy to treat advanced breast cancer that doesn't have high levels of HER2 protein. The goal is to slow or shrink tumors while managing side effects better than traditional high-dose chemotherapy.
Hangzhou, ZhejiangAges 18 years+ - NCT06174428Recruiting
Study of a new oral and throat cancer test
This study is testing a new, simple test that looks for signs of oral or throat cancer. If you have a suspicious spot or symptom, this test might help find out if it's cancer.
St Louis, MissouriAges 18 years+ - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT07295171Recruiting
PET scan study with oral radioactive sugar
This study tests if giving a radioactive sugar drink (instead of an IV) before a PET scan works well for cancer imaging. If you already had a standard PET scan, you may be eligible for a second scan using the oral version.
Vancouver, British ColumbiaAges 19 years+ - NCT04191460RecruitingPhase 2
Fluorescence-guided surgery for oral cancer
This Phase 2 trial tests a special light-tracking medicine (cRGD-ZW800-1) to help surgeons see oral cancer during surgery. The goal is to improve how well the tumor is found and removed while keeping side effects manageable.
Rotterdam, South HollandAges 18 years+
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Common questions
- Are there clinical trials for oral cancer?
- Yes. Clin2 currently lists 282 recruiting oral cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.