Clinical trials
Oral Cancer clinical trials
Below are recruiting oral cancer clinical trials, each written for real people, not researchers. We’re tracking 275 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01958762Recruiting
Cigarette buyers get oral cancer screening
This trial tests whether people who recently bought cigarettes can be offered screening for oral (mouth) cancer. It may help find cancer or warning changes earlier in people at higher risk from smoking.
Amiens, PicardieAges 30–75 - NCT05375266Recruiting
Study of immune signals in head and neck cancer
This study looks at “immune signals” in blood, saliva, and stool to learn more about head and neck cancers (especially squamous cell carcinoma). It may help researchers find patterns that improve understanding of disease or how treatment should be guided.
Erlangen, BavariaAges 18 years+ - NCT07682883Enrolling by invitation
Mouth screening to prevent oral cancer
This study checks how well routine mouth exams can find early signs of oral cancer. It is for adults who do not already have a condition called OPMD (a mouth problem that can lead to cancer) and are not being treated for it.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT06662929Recruiting
Arabic quality of life measure for head and neck cancer patients
This study will test a new Arabic questionnaire to measure how radiotherapy affects the quality of life of head and neck cancer patients. If you are receiving, have received, or will receive radiation treatment for head or neck cancer, you may be able to help by filling out surveys.
RiyadhAges 18 years+ - NCT07606638Enrolling by invitation
Pain Relief Options for Oral Cancer Patients
This study compares two different pain management approaches for people with oral cancer: opioid medication versus a combination of pregabalin (a nerve pain reliever) and naproxen sodium (an anti-inflammatory painkiller). The goal is to see which approach works better and is safer for controlling cancer-related pain.
Lahore, Punjab ProvinceAges 18 years+ - NCT07562100Recruiting
AI-Powered Exercise Program for Oral Cancer Patients Returning to Work
This study tests a smartphone-based exercise and wellness program designed to help people recently diagnosed with oral cancer prepare their body and mind before treatment, with the goal of helping them return to work faster and more safely. Researchers will track whether the program improves recovery and reduces healthcare costs.
TaipeiAges 20–70 - NCT06737822RecruitingPhase 3
Surgery first vs chemo then surgery for oral cancer
This trial compares two approaches for treating oral cancer: having surgery right away or having chemotherapy first followed by surgery. It aims to find which sequence leads to better outcomes for patients.
Bhubaneswar, OdishaAges 18–75 - NCT07296250Recruiting
Tracking cancer cells after chemoradiation for oral cancer
This trial studies whether detecting circulating tumor cells in the blood after chemoradiation can help predict outcomes for people with oral cancer that has spread to lymph nodes. It may help doctors better monitor the disease.
Taoyuan CityAges 1.5 years–90 years - NCT07260344Recruiting
Testing two new ways to find early mouth precancer
This study compares two non-invasive methods to detect precancerous sores in the mouth. It aims to find a simpler way to catch early changes before they become cancer.
Taipei, TaipeiAges 30–80 - NCT07203911Recruiting
Ultrasound guidance for oral cancer surgery
This trial tests whether surgeons can use ultrasound during surgery to better guide the removal of oral cancer. It may help ensure all cancer is removed while sparing healthy tissue.
Stanford, CaliforniaAges 18 years+ - NCT07180901Recruiting
Optimizing care for head and neck cancer surgery patients
This trial uses a computer system to send reminders and tracking alerts to doctors and patients, aiming to improve care and outcomes after surgery for head and neck cancer. It may help you stay on track with your treatment plan.
Montreal, QuebecAges 18 years+ - NCT07166575Recruiting
Trapezius muscle changes after physiotherapy in oral cancer
This trial tests whether physical therapy can help improve shoulder muscle movement in people recently treated for oral cancer. It focuses on patients with scapular dyskinesis, a condition where the shoulder blade doesn't move properly.
TaipeiAges 20–65 - NCT07121595RecruitingPhase 2
Personalized neck radiation for mouth cancer with sentinel node biopsy
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
Ann Arbor, MichiganAges 18 years+ - NCT07122128Recruiting
Saliva test for early oral cancer in people with OSMF
This trial studies whether a simple saliva test can help detect oral cancer early in people who have a condition called oral submucous fibrosis (OSMF), which raises the risk of oral cancer. Healthy volunteers and those with OSMF or proven oral cancer are needed.
Jāmshoro, SinchAges Any age - NCT07090070Recruiting
Treatment study for p53 mutant oral cancer and precancers
This trial tests different treatments for people with oral cancer or precancerous lesions that have a p53 mutation. It aims to find the best approach for early-stage disease to prevent progression.
Vancouver, British ColumbiaAges 18 years+ - NCT07063212RecruitingPhase 2
Sacituzumab govitecan plus cetuximab for head and neck cancer
This trial tests a combination of two drugs—sacituzumab govitecan and cetuximab—for people with advanced head and neck cancer that has gotten worse after immunotherapy. The goal is to see if this new treatment can shrink or slow the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT06941727Recruiting
Mouth Opening and Jaw Muscle Elasticity in Oral Cancer
This study looks at how oral cancer treatment affects your ability to open your mouth and the elasticity of your jaw muscles. It may help researchers understand and prevent long-term jaw stiffness.
TaipeiAges 20–65 - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT06682494Recruiting
Oral Cancer Awareness for African Americans
This study aims to raise awareness about oral cancer in the African American community. It will help researchers understand how to better communicate about prevention and early detection.
Richmond, VirginiaAges 18 years+ - NCT06673329RecruitingPhase 1
Brodalumab for immune-related side effects from cancer treatment
This trial tests if brodalumab, an antibody that blocks a specific immune pathway (IL-17), can help control side effects caused by immunotherapy cancer treatment. It is for people with advanced solid organ cancers who have immune-related side effects that are suspected to involve IL-17.
New York, New YorkAges 18 years+ - NCT06627270RecruitingPhase 2
Antibiotics before surgery for oral cancer
This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.
Cleveland, OhioAges 18 years+ - NCT06601218RecruitingPhase 1
Daily oral cannabis for cancer patients with solid tumors
This trial tests whether taking a daily oral cannabis (marijuana) dose is safe for people with advanced solid tumors (cancer that has spread). It's looking for people who are already on a stable cancer treatment and want to see if adding cannabis affects their symptoms or how they feel.
Lexington, KentuckyAges 18 years+ - NCT06550050Recruiting
Study of Mouth Precancer and Cancer Features
This study looks at tissue and blood samples from people with mouth conditions that could become cancer or are already cancer. It aims to learn more about these conditions to improve diagnosis and treatment.
Houston, TexasAges 18 years+ - NCT06532279RecruitingPhase 2
Testing BMX-001 with chemoradiation for head and neck cancer
This trial tests whether adding BMX-001 (a drug that may protect healthy tissues) to standard chemoradiation can reduce side effects and improve outcomes for people with head and neck cancer. It's a randomized study, so you would have a 50/50 chance of getting BMX-001 or a placebo.
Gilbert, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for oral cancer?
- Yes. Clin2 currently lists 275 recruiting oral cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.