Testing two immunotherapy drugs before surgery for advanced head and neck cancer
Treatments studied
Part of Cancer, Ear, nose & throat, Lungs & breathing, Mouth & dental clinical trials.
This trial tests whether adding a second immunotherapy drug (CDX-1140) to the standard immunotherapy cemiplimab before surgery is better than cemiplimab alone for people with stage III-IV head and neck cancer that can be removed with surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stage III or IV head and neck squamous cell cancer (mouth, throat, voice box, or nasal cavity) that can be surgically removed and is accessible for a biopsy.
- If you have oropharyngeal cancer (throat cancer), it must not be linked to HPV (p16-negative).
- You are 18 years or older.
- Your overall health allows you to be up and about (ECOG score 0-2).
- You have not had prior treatment with a PD-1 or PD-L1 inhibitor (like cemiplimab).
- You do not have an active autoimmune disease or history of it in the past 2 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.
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