Clinical trials
Osteoarthritis (OA) clinical trials
Below are recruiting osteoarthritis (oa) clinical trials, each written for real people, not researchers. We’re tracking 79 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75 - NCT07246109Enrolling by invitation
Knee Brace and Muscle Training for Osteoarthritis
This study tests whether wearing a knee brace and doing muscle training exercises can help people with knee osteoarthritis feel better and move more easily. It may be a good option if you have not had knee surgery and are not already in another treatment program.
TaichungAges 55 years+ - NCT07065591RecruitingEarly Phase 1
Metformin, Exercise, and Diet for Knee Osteoarthritis
This trial tests whether a common diabetes drug (metformin) combined with exercise and a healthy diet can help people with knee osteoarthritis who are overweight.
Hong Kong, Sandy BayAges 40–80 - NCT07153471RecruitingPhase 3
A study of an experimental pill for weight loss and knee arthritis
This trial tests an investigational medication (orforglipron) to see if it helps people with knee arthritis lose weight. You may qualify if you have overweight or obesity and have tried dieting before without lasting success.
Phoenix, ArizonaAges 18 years+ - NCT07308873Recruiting
Gait and knee osteoarthritis pain study
This study looks at how walking patterns relate to knee pain from osteoarthritis. It aims to understand individual differences to improve future treatments.
Pittsburgh, PennsylvaniaAges 45–80 - NCT06281184Enrolling by invitation
Long-term follow-up of methotrexate for hand osteoarthritis
This study follows up on people who took part in the MERINO trial to see if methotrexate has lasting benefits for hand osteoarthritis. It aims to understand how the drug affects pain and joint health over 30 months.
OsloAges 18 years+ - NCT07130630Recruiting
Pain and activity confidence in Vietnamese knee osteoarthritis
This study tests a questionnaire that measures how confident people with knee osteoarthritis feel about doing daily activities despite pain. Your answers will help doctors better understand and support Vietnamese-speaking patients.
Ho Chi Minh City, Ho Chi MinhAges 50 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT07320118Recruiting
Knee cartilage repair and osteoarthritis prevention study
This study looks at whether fixing knee cartilage damage can prevent arthritis later. It compares different treatments to see if they help avoid long-term joint problems.
OswestryAges Any age - NCT06845553RecruitingPhase 2
Vutiglabridin for knee osteoarthritis: a phase 2 study
This trial tests an experimental pill called Vutiglabridin for people with knee osteoarthritis. It aims to see if the drug is safe and effective at reducing knee pain and improving function.
Seongnam-si, Gyeonggi-doAges 40–75 - NCT06875817Recruiting
Feldenkrais exercises for knee osteoarthritis pain
This study tests if gentle, slow Feldenkrais movement exercises can reduce knee pain and improve mobility in people with moderate knee osteoarthritis. It is designed for those who are still able to walk and get up from the floor, but are experiencing significant pain.
Lahore, Punjab ProvinceAges 40–60 - NCT04651673Enrolling by invitation
Knee brace program for adults with knee osteoarthritis pain
This trial looks at using a prescribed knee brace to help relieve knee pain and symptoms from knee osteoarthritis. You may be able to join if your knee braces are being provided through participating clinics and you can consent and complete study questionnaires.
Hässleholm, Skåne CountyAges 18–100 - NCT06596824Recruiting
Digital training to reduce inflammation after ACL knee surgery
This trial tests a personalized digital training program for people who recently had ACL knee surgery. The goal is to see if correcting movement patterns can lower inflammation and prevent early knee arthritis.
BerlinAges 18–50 - NCT07347054Recruiting
Trigger point injection for shoulder arthritis pain
This study tests whether injecting a medication into painful knots in the shoulder muscle can reduce pain from shoulder arthritis. It may be a good option if you have had shoulder pain for at least 3 months and other treatments haven't worked well enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07347041Recruiting
Trigger point injections for hip osteoarthritis pain
This study tests if injecting pain-relieving medication into tight muscle knots (called trigger points) can reduce hip pain from osteoarthritis. It is for people who still have pain despite trying other treatments.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT06930677Recruiting
Knee osteoarthritis treatment study using embolization
This trial tests a new treatment called embolization using a special material (NBGM200) to block certain blood vessels in the knee. It may help reduce pain and improve function in people with knee osteoarthritis.
GhentAges 50 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07589127Recruiting
Nerve Block for Pain Relief During Knee Replacement
This study tests whether blocking a specific nerve in the knee can reduce pain and improve recovery after total knee replacement surgery. You would receive this nerve block alongside standard anesthesia to see if it helps you need fewer pain medications afterward.
Hjelset, Møre og RomsdalAges 18–80 - NCT07592871Recruiting
Knee Injury and Arthritis Long-Term Health Study
This study follows patients with knee injuries or wear-and-tear arthritis over time to understand how these conditions develop and change. Your health information helps doctors learn what treatments work best and how to prevent problems.
Ningbo, ZhejiangAges 18–90 - NCT02966886Recruiting
Shoulder replacement techniques for advanced shoulder arthritis
This study compares different surgical techniques during shoulder replacement for people with advanced shoulder (glenohumeral) arthritis. It may help surgeons choose the approach that best restores function and reduces pain.
Ottawa, OntarioAges 18 years+ - NCT05147675RecruitingPhase 1
Testing cord stem cell treatment for osteoarthritis safety
This early study (Phase 1) checks whether an infused stem cell product made from donated umbilical cord tissue is safe in people with osteoarthritis. It’s mainly looking for side effects and whether the treatment can be given safely.
St John'sAges Any age - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT06088160Recruiting
Balance changes after hip replacement for arthritis
This study looks at how your balance changes after a hip replacement for arthritis. You will have your balance tested before and after surgery to help doctors understand recovery.
London, OntarioAges 60 years+
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Common questions
- Are there clinical trials for osteoarthritis (oa)?
- Yes. Clin2 currently lists 79 recruiting osteoarthritis (oa) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis (oa) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis (oa) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.