Clinical trials · North Carolina
Osteoarthritis clinical trials in North Carolina
We’re tracking 21 recruiting osteoarthritis studies with a site in North Carolina — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT06096259RecruitingPhase 2
Preventing knee arthritis after ACL injury
This trial tests whether metformin, a common diabetes medicine, can prevent arthritis after an ACL injury. If you are planning to have ACL surgery soon, you may be able to join.
Chapel Hill, North CarolinaAges 18–45 - NCT06477965Recruiting
Registry for artery embolization to treat chronic pain
This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.
Cary, North CarolinaAges 18 years+ - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Charlotte, North CarolinaAges 40 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Morehead City, North CarolinaAges 45–80 - NCT07153471RecruitingPhase 3
A study of an experimental pill for weight loss and knee arthritis
This trial tests an investigational medication (orforglipron) to see if it helps people with knee arthritis lose weight. You may qualify if you have overweight or obesity and have tried dieting before without lasting success.
Shelby, North CarolinaAges 18 years+ - NCT07405983Recruiting
New study of a thumb joint replacement for arthritis
This study tests a new implant (TOUCH® CMC) for people with thumb arthritis. It aims to see if the implant relieves pain and improves function.
Morrisville, North CarolinaAges 22 years+ - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Chapel Hill, North CarolinaAges 50 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Wilmington, North CarolinaAges 18 years+ - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Statesville, North CarolinaAges 18 years+ - NCT07339111RecruitingPhase 3
CARTISTEM vs surgery for knee cartilage damage and osteoarthritis
This trial tests if a cell-based treatment called CARTISTEM can repair knee cartilage better than surgery alone. It involves people with knee osteoarthritis and a cartilage defect, with moderate pain and limited function.
Charlotte, North CarolinaAges 18–75 - NCT06631638Recruiting
New hip replacement study using smart navigation
This study tests a hip replacement system that uses a special navigation tool to help the surgeon place the new hip cup more precisely. It may lead to better long-term results and fewer complications.
Gastonia, North CarolinaAges 21 years+ - NCT07104279Recruiting
Zimmer Biomet hip implant follow-up study
This study is for people who need a hip replacement for the first time. It is testing a specific hip implant system called the Z1 Hip System and will follow patients to see how well it works over time.
Charlotte, North CarolinaAges 18 years+ - NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Asheville, North CarolinaAges Any age - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Durham, North CarolinaAges 21 years+ - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Greensboro, North CarolinaAges 18 years+ - NCT06090097Recruiting
Game therapy for knee osteoarthritis
This trial tests a game-based therapy that uses biofeedback to help strengthen your knee. It may help you move better and feel less pain.
Chapel Hill, North CarolinaAges 30–75 - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT07215572Recruiting
Group physical therapy for veterans with knee osteoarthritis
This trial studies whether a group physical therapy program can help veterans with knee osteoarthritis. It aims to see if this approach is practical and effective for improving knee pain and function.
Durham, North CarolinaAges Any age - NCT06988163Enrolling by invitation
Osteoarthritis care tools for primary care doctors
This study tests a tool to help doctors manage osteoarthritis care. You may join if you are a healthcare provider at the UNC pilot clinic or a patient who has been referred to the 'Walk With Ease' program by that clinic, are 18 or older, and speak English.
Chapel Hill, North CarolinaAges 18–99
Where these studies are running in North Carolina
Institutions with a site for the recruiting osteoarthritis studies listed above.
- University of North Carolina at Chapel Hill · 5 studies
- Wake Forest University Health Sciences · 2 studies
- West Clinical Research · 2 studies
- Accellacare
- Atrium Health Mercy
- Blue Nine Systems
- Carolina Orthopaedic and Sports Medicine Center
- Carolina Research Center, Inc
What taking part in a osteoarthritis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Osteoarthritis trials in other states
Common questions
- Are there osteoarthritis clinical trials in North Carolina?
- Yes. We're currently tracking 21 recruiting osteoarthritis studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a osteoarthritis study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New osteoarthritis studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.