Preventing knee arthritis after ACL injury
Treatments studied
Part of Bones, joints & muscles, Injuries & trauma clinical trials.
This trial tests whether metformin, a common diabetes medicine, can prevent arthritis after an ACL injury. If you are planning to have ACL surgery soon, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 45 years old (if you are 18–24, you must have knee pain scores below 80).
- You tore your ACL within the last 6 months.
- You plan to get ACL reconstruction surgery within 12 months of your injury.
- You are not currently taking metformin or topiramate, and you do not have diabetes or kidney problems.
- You do not have inflammatory arthritis, a previous ACL tear on the same knee, or a recent ACL tear on the other knee.
- You are not pregnant, breastfeeding, or planning to get pregnant in the next year.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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