Clinical trials
Personality Disorder clinical trials
Below are recruiting personality disorder clinical trials, each written for real people, not researchers. We’re tracking 136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04852744Recruiting
Brain scan study in teens with borderline and/or PTSD
This study uses brain imaging (MRI) to compare brain patterns in teens with borderline personality disorder and those with PTSD, as well as teens without these mental health diagnoses. It may help researchers understand what brain differences go along with these conditions and how they relate to each other.
CaenAges 13–18 - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT06018272Recruiting
Mentalization therapy for borderline personality disorder
This trial compares a therapy called mentalization-based treatment with other proven therapies for people with borderline personality disorder. It aims to find out which approach works better for reducing self-harm and suicidal behaviors.
BerlinAges 18–65 - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT06839950Recruiting
Sensory profiles and early signs in calm room users
This study looks at the sensory experiences of people newly admitted to a closed psychiatric unit who use a calm room. Researchers want to see if certain early signs or responses to the calm room differ based on a person's unique sensory profile.
Limoges, New AquitaineAges 18–65 - NCT06675461Enrolling by invitation
Brief talk therapy for suicidal patients with borderline personality disorder
This trial tests a short talk therapy for people with borderline personality disorder who come to the emergency department after hurting themselves or thinking about suicide. The goal is to see if this brief help can ease suicidal thoughts and keep you safer.
Toronto, OntarioAges 16 years+ - NCT06591754Enrolling by invitation
Personality disorder therapy study at Karolinska
This trial tests a special talk therapy (ISTDP) for people with personality disorders. It aims to see if the therapy helps in a psychiatric clinic setting.
StockholmAges 18 years+ - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
Boston, MassachusettsAges 18 years+ - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT06592963Recruiting
Understanding long-term eating disorders and recovery
This study looks at severe and lasting eating disorders to better understand recovery and needed support. It uses information from a past local registry and ongoing interviews with people who have had symptoms for at least seven years.
Uppsala, Uppsala CountyAges 18 years+ - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT06623838Recruiting
Personality study for final-year or recent graduates
This study explores personality traits and patterns using an evolutionary framework. It is open to students who are finishing their undergraduate degree or have just graduated.
FlorenceAges Any age - NCT06972368Recruiting
Home brain stimulation for depression in borderline personality disorder
This trial tests whether a gentle brain stimulation device (tDCS) used at home can help with depression in people with borderline personality disorder. If you have BPD and current depression, you may be able to participate from home using your smartphone.
Montreal, QuebecAges 18–65 - NCT06580457Recruiting
Personalized smartphone program for Veterans with substance use
This study tests a personalized smartphone program to help Veterans reduce harmful substance use. It uses daily surveys and feedback to support healthier habits.
Minneapolis, MinnesotaAges 18 years+ - NCT05821634Enrolling by invitation
Personalized telehealth counseling for anxiety and alcohol use
This study personalizes how telehealth counseling is delivered for people dealing with anxiety or trauma-related symptoms and alcohol use problems. It may help by tailoring counseling timing and approach to what you need.
Piscataway, New JerseyAges 18–65 - NCT05712057Recruiting
Brain stimulation vs therapy for emotion regulation problems
This trial compares a type of brain stimulation (rTMS) to therapy to help people better manage strong emotions. You may be eligible if you have ongoing difficulties with emotion control and meet specific mood, anxiety, or related symptom criteria.
Durham, North CarolinaAges 18–55 - NCT05765864Recruiting
Study of self-harm in at-risk teens
This study looks at self-harm and thoughts/behaviors related to safety in teenagers who are considered at higher risk. It may help researchers better understand what supports are needed for teens who self-harm without wanting to die.
LjubljanaAges 13–18 - NCT05942651Recruiting
tMS for impulsivity in borderline personality disorder
This trial studies whether magnetic brain stimulation (tMS) can reduce impulsive symptoms in people with borderline personality disorder. It may help by changing how brain networks involved in impulse control work.
Bron, AURAAges 18 years+ - NCT06772831Recruiting
Cognitive reappraisal training for borderline personality
This study tests a thinking strategy called 'cognitive reappraisal training' for people with borderline personality disorder (BPD). The goal is to see if this training helps manage emotions and symptoms related to BPD.
New York, New YorkAges 18–55 - NCT05699525Recruiting
Personalized app for cognitive behavioral therapy for young adults
This trial tests a mobile app that delivers personalized cognitive behavioral therapy (a structured talk-therapy approach that helps change unhelpful thoughts and behaviors). It may help reduce symptoms of anxiety, depression, or bipolar disorder for people who fit the study’s timing and safety requirements.
New York, New YorkAges 18–25 - NCT06208605Recruiting
Personalized eating disorder treatment study
This study is testing a new way to personalize treatment for people with an active eating disorder (except ARFID). It aims to find what works best for you.
Louisville, KentuckyAges 18–65 - NCT06726187Recruiting
Autism and personality in adults
This study looks at personality traits and disorders in adults with autism. You and someone who knows you well will answer questions to help researchers understand how autism and personality relate.
RotterdamAges 18 years+ - NCT05548946Recruiting
Study of personality patterns in adults age 65 and older
This study looks at personality patterns in older adults using information gathered from participants. It may help researchers better understand how these patterns show up later in life.
Tienen, Vlaams-BrabantAges 18 years+ - NCT07078227Recruiting
Long-term depression follow-up study
This study follows up with people who took part in an earlier research project on depression and genetics. The goal is to see how depression changes over time.
LundAges 18 years+
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Common questions
- Are there clinical trials for personality disorder?
- Yes. Clin2 currently lists 136 recruiting personality disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a personality disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a personality disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.