Clinical trials
Post-Traumatic Stress clinical trials
Below are recruiting post-traumatic stress clinical trials, each written for real people, not researchers. We’re tracking 149 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06296589Recruiting
Guilt Reduction vs. Prolonged Exposure for PTSD in Veterans
This study compares two types of talk therapy for Veterans with PTSD who also struggle with trauma-related guilt. One therapy focuses on reducing guilt, while the other is a standard trauma-focused treatment.
Little Rock, ArkansasAges 18 years+ - NCT06298279Recruiting
Online CBT for public safety personnel in Canada
This study tests an online therapy program (cognitive behavioral therapy, or CBT) designed specifically for public safety personnel. It looks at how the timing of the course and learning from others affects your progress. You can join from anywhere in Canada.
Regina, SaskatchewanAges 18 years+ - NCT06296186Recruiting
PTSD treatment for veterans in substance use recovery
This trial tests a condensed form of prolonged exposure therapy for PTSD in veterans who are also receiving treatment for a substance use disorder. The goal is to help you process trauma and reduce substance use together.
San Diego, CaliforniaAges 18 years+ - NCT06215313Enrolling by invitation
Comparing two therapies for trauma memories
This study compares two types of therapy—EMDR and imagery rescripting—to help people who have upsetting memories or nightmares from past events. It's for people with depression or PTSD, and you'll need to come to therapy twice a week.
Eindhoven, North BrabantAges 18–70 - NCT06194851RecruitingPhase 2
Oxytocin nasal spray plus couples therapy for Veterans with PTSD
This study tests whether a nasal spray of oxytocin (a natural hormone) can boost the effects of a brief couples therapy for Veterans with PTSD. You and your partner would receive either the spray or a placebo (inactive spray) during therapy sessions to see if it helps reduce PTSD symptoms and improve relationship satisfaction.
San Diego, CaliforniaAges 18 years+ - NCT06179485Enrolling by invitation
Ketamine vs. Etomidate for emergency breathing tube: long-term study
This study compares how two common medicines (ketamine and etomidate) used during emergency breathing tube placement affect long-term recovery. It is only for patients already enrolled in another related trial.
Birmingham, AlabamaAges 18 years+ - NCT06138522Recruiting
How Teens View Changes in PTSD Therapy
This study talks with traumatized teens and their therapists to understand how their therapy changes over time. It aims to improve care for young people with PTSD.
Paris, IDFAges 12 years+ - NCT06096740Recruiting
Talking therapy for PTSD and its effects on the brain
This study looks at how a specific type of talk therapy affects the way your brain processes rewards. You'd join a group that either starts therapy right away or waits a bit before starting. Your brain activity will be scanned with an MRI to see changes.
Austin, TexasAges 18–65 - NCT06088303Recruiting
Improving PTSD treatment through better communication
This study tests if improving how you talk with your doctor can make PTSD treatment work better. You can join if you have PTSD and have been on stable medications for at least 4 weeks.
Boston, MassachusettsAges 18 years+ - NCT05560113Recruiting
Study uses brain stimulation to disrupt fear memory in PTSD
This study tests a brain stimulation approach to affect how fear memories “stick” after they are formed. If you have PTSD, it may help reduce fear-related learning, but you must meet several safety and health criteria.
Atlanta, GeorgiaAges 18–65 - NCT03755401Recruiting
Therapy trial for PTSD after prior treatment didn’t fully help
This trial studies a specific talk-therapy approach (psychodynamic psychotherapy) for people with post-traumatic stress disorder (PTSD) who still have significant symptoms despite prior treatment. You may be able to join if your PTSD symptoms are in a moderate range and you can safely participate without urgent safety risks or certain other conditions.
New York, New YorkAges 18–70 - NCT04585685Recruiting
Healthy recovery program for PTSD after sexual trauma
This study looks at how to help people recover from PTSD symptoms after sexual trauma, including feeling mentally “contaminated.” You may be eligible if you currently meet criteria for PTSD and report these contamination feelings, and you can avoid starting other trauma treatments during the study.
Lexington, KentuckyAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT03578003Recruiting
Bright morning light to improve sleep in veterans
This study tests whether using bright morning light can improve sleep quality in veterans. You may be able to join if you’re not already using a light box and you don’t have certain eye or mood conditions.
Portand, OregonAges 18 years+ - NCT06035809Recruiting
Smart treatment study for PTSD using brain activity feedback
This study tests a new therapy called SMART, which uses brain imaging to help regulate arousal linked to PTSD. It aims to see if combining brain feedback with therapy reduces PTSD symptoms.
London, OntarioAges 18–65 - NCT06002633Recruiting
Alcohol effects and brain responses in PTSD
This study explores how people with PTSD respond to alcohol and how their brains handle approach or avoidance situations. You may participate if you drink alcohol occasionally and are between 21 and 60 years old.
Austin, TexasAges 21–60 - NCT05974631Recruiting
Treatments for suicidal Veterans with PTSD
This study tests two types of therapy to help Veterans with PTSD who are struggling with suicidal thoughts and self-harm. It compares a treatment called DBT (Dialectical Behavior Therapy, which helps with emotions) with another called PE (Prolonged Exposure, which helps with trauma).
Minneapolis, MinnesotaAges 18 years+ - NCT06000475Recruiting
Memory boosting therapy for PTSD in veterans
This trial is testing a type of therapy called Cognitive Processing Therapy (CPT) for PTSD, along with memory exercises to help enhance the therapy's effects. It is for veterans who have PTSD and want to see if adding memory training can improve their treatment.
Philadelphia, PennsylvaniaAges 60 years+ - NCT05934175Recruiting
Intensive therapy vs weekly trauma therapy for PTSD
This trial compares an intensive course of prolonged exposure therapy versus a standard weekly schedule for adults with post-traumatic stress disorder (PTSD). It may help you and your care team choose a treatment schedule that reduces PTSD symptoms.
StockholmAges 18 years+ - NCT05853627RecruitingPhase 4
Propranolol versus standard therapy for trauma imagery reactions
This study tests whether propranolol (a beta-blocker) changed alongside a standard approach can reduce how strongly your body reacts during traumatic imagery. It’s meant for adults who have had a traumatic event and may help lessen fear and stress responses tied to those memories.
Charlestown, MassachusettsAges 18–65 - NCT05674617Recruiting
PTSD treatment for Veterans with serious mental illness
This trial tests a PTSD treatment approach for Veterans who also have a serious mental illness, aiming to improve day-to-day functioning. It includes Veterans who receive outpatient mental health care through the VA and have confirmed PTSD in the last month.
Baltimore, MarylandAges 18 years+ - NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Eglin Air Force Base, FloridaAges 18 years+ - NCT05619822Enrolling by invitation
Third-steps therapy for psychosis and PTSD symptoms
This study tests a structured therapy program for people who have both psychosis symptoms and high PTSD symptoms. It aims to reduce distress from past trauma while also supporting mental health symptoms.
Pozuelo de Alarcón, MadridAges 18–65 - NCT05517304Recruiting
Nerve stimulation for veterans with PTSD
This study tests a device that stimulates a nerve in the neck to see if it helps with PTSD symptoms. It is for veterans who have PTSD, but have not had a brain injury or certain other health issues.
Decatur, GeorgiaAges 18–75
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Common questions
- Are there clinical trials for post-traumatic stress?
- Yes. Clin2 currently lists 149 recruiting post-traumatic stress studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a post-traumatic stress trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a post-traumatic stress trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.