Clinical trials · California
Primary Health Care clinical trials in California
We’re tracking 23 recruiting primary health care studies with a site in California — including Phase 1, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07290361Recruiting
Physical therapy for spine pain in primary care
This trial tests a program that connects people with spine pain (neck or back pain) from their primary care clinic to a physical therapist. The goal is to see if this approach helps patients get more timely and effective care.
San Diego, CaliforniaAges 18 years+ - NCT07552311Recruiting
Fitbit AI Care Planning Study
This study tests a new artificial intelligence tool designed to help create personalized health plans using your Fitbit data and Google account. Researchers want to learn if this AI-powered planning tool can help you better manage your health.
Mountain View, CaliforniaAges 18 years+ - NCT06090578Recruiting
Brain health check for adults in primary care
This trial tests a new brain health assessment tool in primary care clinics. It may help your doctor better detect thinking or memory changes early.
Pasadena, CaliforniaAges 18 years+ - NCT05751473Recruiting
Reducing PTSD symptoms for first responders and frontline health workers
This study tests a way to help reduce PTSD symptoms in first responders and frontline healthcare workers. You may join a main treatment study, and some participants may also take part in follow-up questions to learn what helped.
San Diego, CaliforniaAges 18 years+ - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
San Diego, CaliforniaAges 18 years+ - NCT06486688Recruiting
Virtual program to help teens with substance use risk
This trial tests a virtual program integrated into pediatric check-ups to help teens at risk for alcohol or drug problems. It aims to identify teens who may need extra support and connect them with helpful resources.
Pleasanton, CaliforniaAges 12–17 - NCT05958654Recruiting
Screening for risk of readmission during home care visits
This study tests a universal “screening” approach during home-based primary care visits to spot which patients may be at higher risk of problems that could require urgent care or hospital return. It may help patients and their care team catch risks earlier and adjust care sooner.
San Francisco, CaliforniaAges 18 years+ - NCT05570734Recruiting
Study of diabetes support for Hispanic/Latino adults online
This study looks at an online (e-health) way to help adults with type 2 diabetes better follow their diabetes care plan. It targets Hispanic/Latino patients and may help improve how consistently people manage their diabetes.
Chula Vista, CaliforniaAges 18 years+ - NCT06699251Recruiting
Brief chat with your doctor about alcohol or cannabis for teens
This study tests whether a short, one-time conversation with a primary care provider can help teens who are at risk for alcohol or cannabis use. It's designed for young people ages 12–17 who get care at two specific health systems.
Commerce, CaliforniaAges 12–19 - NCT06664034Recruiting
Health support for young rural women cancer survivors
This study offers a program to help young women in rural Imperial County, California, who have had cancer, improve their health after treatment. It provides support for their overall well-being.
Brawley, CaliforniaAges 15–50 - NCT05588583Recruiting
Tracking drainage from chronic leg or foot ulcers with a dressing
This study follows how much fluid (drainage) a chronic ulcer produces over time using a dressing called Mepilex Up. It may help clinicians better understand how this dressing manages “exuding” ulcers on the leg or foot.
Castro Valley, CaliforniaAges 18 years+ - NCT07290478Enrolling by invitation
Helping You Choose a Health Care Proxy
This study helps you name someone to make health decisions for you if you can't. It's for older adults or people with serious conditions, and it aims to make this important choice easier.
Martinez, CaliforniaAges 18 years+ - NCT06415721Recruiting
TMS guided by brain scans for alcohol use disorder
This study uses a brain stimulation technique called TMS combined with MRI scans to treat alcohol use disorder. It aims to see if targeting specific brain connections can help reduce drinking.
Palo Alto, CaliforniaAges 25–75 - NCT07314697Recruiting
Arrival Time Study at UCLA Health
This study aims to see if adjusting the time patients arrive for their appointments can improve the clinic experience. If you already have a UCLA Health appointment in primary care or pediatrics, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT06568016Recruiting
Helping patients get colonoscopy after abnormal stool test
This study tests a new clinic program to help patients complete a colonoscopy if they received an abnormal result from a fecal immunochemical test (FIT), a simple stool test for colon cancer. It focuses on community health centers and aims to make follow-up care easier.
Los Angeles, CaliforniaAges Any age - NCT07642414Recruiting
Digital program combining exercises and mindfulness for migraines
This 12-week online program uses exercises, mindfulness, and digital tracking to help reduce migraines. You'll work with the app on your smartphone while staying on your current migraine medications.
San Francisco, CaliforniaAges 18 years+ - NCT06962800RecruitingPhase 3
Study of felzartamab for adults with primary membranous nephropathy
This study tests whether felzartamab, given as an infusion, can help treat primary membranous nephropathy (a kidney disease causing protein in the urine and swelling). It may reduce protein loss and improve kidney function compared to standard care alone.
Fresno, CaliforniaAges 18–80 - NCT06386198Recruiting
Health Advocate for Young Liver Transplant Patients
This study tests a program that helps young adults with a liver transplant prepare to move from a children’s hospital to an adult hospital. It aims to provide extra support for people who also have social needs like trouble getting enough food.
San Francisco, CaliforniaAges 18–25 - NCT07528261Recruiting
Support Group for Family Caregivers of Stroke Survivors
This study tests whether a support group using acceptance and commitment therapy (a type of counseling that helps people cope with stress) can reduce caregiver burden and distress. You would meet online with other people caring for stroke survivors.
Alameda, CaliforniaAges 40 years+ - NCT06598436Recruiting
Digital coaching for better diabetes or blood pressure control
This study offers a digital health coaching program to help people with poorly controlled diabetes or high blood pressure manage their condition. It works through telehealth tools and is designed for patients at San Francisco Health Network primary care clinics.
San Francisco, CaliforniaAges 18 years+ - NCT07011914Recruiting
MS care study for young adults
This study looks at how to improve care for young adults with relapsing-remitting MS. It focuses on people who are Black, Hispanic, or have limited income.
San Francisco, CaliforniaAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT07221370RecruitingPhase 2/Phase 3
Vancomycin to prevent C. diff infection in ICU patients
This trial tests whether giving vancomycin through a tube into the stomach can prevent a serious gut infection called C. diff in people who are very sick in the ICU and taking antibiotics. If you qualify, you might receive this medicine to lower your risk.
Moreno Valley, CaliforniaAges 18 years+
Where these studies are running in California
Institutions with a site for the recruiting primary health care studies listed above.
- University of California, San Francisco · 5 studies
- University of California, Los Angeles (UCLA) · 2 studies
- Academic Medical Research Institute
- AltaMed Health Services
- Cancer Resource Center of the Desert
- Center for Clinical Research Inc.
- Contra Costa Regional Medical Center
- El Centro Regional Medical Center
What taking part in a primary health care study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Common questions
- Are there primary health care clinical trials in California?
- Yes. We're currently tracking 23 recruiting primary health care studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a primary health care study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a primary health care trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New primary health care studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.