Clinical trials
Progressive Multiple Sclerosis clinical trials
Below are recruiting progressive multiple sclerosis clinical trials, each written for real people, not researchers. We’re tracking 133 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07085676RecruitingPhase 1
CAR-T cell therapy for autoimmune diseases that resist treatment
This study tests a new cell therapy called CAR-T (using your own immune cells) for people with severe autoimmune diseases like lupus, scleroderma, or myositis that have not improved with standard treatments. The goal is to see if it can safely reduce disease activity.
JerusalemAges 18–80 - NCT07139743RecruitingPhase 1
Obe-cel for progressive multiple sclerosis that is getting worse
This study tests a new treatment called obe-cel, a type of CAR T-cell therapy, for people with progressive multiple sclerosis that hasn't responded to other treatments. It aims to see if this therapy can slow or stop the disease from getting worse.
Redwood City, CaliforniaAges 18–60 - NCT07178431RecruitingPhase 1/Phase 2
CAR T-cell therapy for worsening multiple sclerosis
This trial tests a new treatment called MB-CART2019.1, which uses your own immune cells to fight multiple sclerosis. It is for people with progressive or worsening MS who have not responded well to other treatments.
BerlinAges 18–55 - NCT07222618Recruiting
Selfie videos to measure function in MS
This trial asks people with MS to record short 'selfie' videos of themselves doing everyday tasks, like walking or getting dressed. The goal is to find a better, more personal way to measure how MS affects daily function.
San Francisco, CaliforniaAges 18 years+ - NCT05359653RecruitingPhase 1/Phase 2
Clemastine to study MRI changes in relapsing MS
This early-phase study tests whether clemastine (a drug being studied for “myelin repair”) changes how MS looks on special MRI scans. It may help researchers understand if the treatment supports restoring nerve covering in people with relapsing-remitting MS.
San Francisco, CaliforniaAges 18–55 - NCT07303790RecruitingEarly Phase 1
Study of GC012F for people with multiple sclerosis
This early phase trial tests a new treatment called GC012F for people with multiple sclerosis. It aims to see how safe and tolerable it is, and may offer a new option for those whose current treatments are not working well enough.
Hubei, HubeiAges 18 years+ - NCT07325292RecruitingPhase 3
Frexalimab injection vs IV for multiple sclerosis
This study tests if a new injection (frexalimab) works as well as the IV version for people with relapsing or certain types of secondary progressive multiple sclerosis. It could offer a more convenient way to receive this treatment at home.
Cullman, AlabamaAges 18–60 - NCT07342777Recruiting
Exercise for Pain Relief in Multiple Sclerosis
This study tests whether exercise can help reduce pain in people with multiple sclerosis. If you have MS and moderate to severe pain, you may be asked to participate in a supervised exercise program.
Aarhus, DenmarkAges 18 years+ - NCT07355387Recruiting
Home-based balance training for multiple sclerosis
This study tests a 12-week home-based balance training program for people with multiple sclerosis. Sessions are done online with a helper present, and the goal is to improve walking and reduce fall risk.
Chicago, IllinoisAges 40–90 - NCT07392879Recruiting
Virtual nature walks for depression in MS
This study tests whether virtual reality nature walks can help improve depression in people with progressive multiple sclerosis. You will use a VR headset at home to watch calming nature scenes, and researchers will see how it affects your mood.
Ann Arbor, MichiganAges 18 years+ - NCT01703429Recruiting
Alternative care program for people with multiple sclerosis
This study looks at how a complementary or alternative care approach affects people living with multiple sclerosis. It may help to understand whether this type of program improves symptoms or quality of life over time.
Kenmore, WashingtonAges 18–100 - NCT02912897RecruitingPhase 1
EBV T-cell treatment for early multiple sclerosis-like symptoms
This early-phase study tests whether a patient’s own immune cells (made to target a common virus called EBV) are safe and practical for people who have their first episode that strongly suggests multiple sclerosis. If it works well, it could offer a new way to treat early disease—but the main goal now is safety and feasibility.
NantesAges 18–45 - NCT06675864RecruitingPhase 1/Phase 2
YTB323 for non-active progressive MS
This trial tests a new treatment called YTB323, which is a type of personalized cell therapy (CAR-T) designed to target your immune system and slow down MS progression. It is for people with non-active progressive MS who have seen their disability worsen recently.
Darlinghurst, New South WalesAges 18–60 - NCT07426991Recruiting
Multiple sclerosis, thinking, sleep, and tiredness study
This study looks at how multiple sclerosis (MS) affects your thinking, sleep, and tiredness. It compares people with MS who have at least mild fatigue to people without MS who also have sleep problems, to understand these issues better.
DüsseldorfAges 18–79 - NCT07477639RecruitingPhase 1/Phase 2
Testing TRX319 for worsening multiple sclerosis
This trial tests a new treatment called TRX319 for people with progressive multiple sclerosis (MS) that has been getting worse. The study wants to see if this treatment can help slow down disability progression.
Kansas City, KansasAges 18–65 - NCT07667322RecruitingPhase 1
Study of a new under-the-skin multiple sclerosis treatment
This trial tests a new way to give ocrelizumab, an approved MS treatment, as a shot under the skin instead of through an IV. It aims to see if it's safe and works well for people with relapsing or primary progressive MS.
Carlsbad, CaliforniaAges 18–65 - NCT07567989Enrolling by invitation
Home Exercise and Brain Stimulation for MS Fatigue
This study tests whether doing exercises at home combined with a non-invasive brain stimulation technique (gentle electrical stimulation on your scalp) can reduce the exhaustion and tiredness that comes with multiple sclerosis. The goal is to see if this combination helps you feel less fatigued and improves your ability to stay active.
A Coruña, A CoruñaAges 18–75 - NCT06495593Enrolling by invitationPhase 4
Ocrelizumab's effect on immune cells in lymph nodes in MS
This study tests how ocrelizumab, a medication for MS, affects immune cells in your lymph nodes. It may help doctors understand how the drug works and why it helps some people more than others.
San Francisco, CaliforniaAges 18–65 - NCT06261528Enrolling by invitationPhase 1
Light therapy for sleepiness in progressive MS
This trial tests whether a special light therapy can help people with progressive multiple sclerosis who feel sleepy during the day. It aims to improve energy, mood, and sleep patterns.
Dallas, TexasAges 18 years+ - NCT05706220Enrolling by invitation
Eye tests to measure visual speed in multiple sclerosis
This study tests how fast and how accurately your eyes process visual information and how eye movements look in people with multiple sclerosis. It may help researchers understand vision-related effects of MS using objective eye measurements.
Valladolid, ValladolidAges 18–80 - NCT04625049Enrolling by invitation
PET and MRI study in people with multiple sclerosis
This trial studies how certain brain immune activity relates to multiple sclerosis (MS) lesion growth and progression using PET and MRI scans. Your participation may help researchers understand disease changes over time and improve how MS is tracked.
Turku, Southwest FinlandAges 30–80 - NCT03032601Enrolling by invitation
N-acetyl cysteine study for people with multiple sclerosis
This study tests whether N-acetyl cysteine (a supplement-like medicine) changes body and brain function in people with multiple sclerosis. It may help researchers understand how it affects brain chemistry and activity using special brain imaging.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07503873RecruitingPhase 2
Study of ublituximab injection for multiple sclerosis
This trial tests a new way to give the drug ublituximab (an injection under the skin) to people with relapsing multiple sclerosis. It compares different injection sites and a special auto-injector device to see how the body absorbs the drug and if it's safe.
BihaćAges 18–65 - NCT04694534Recruiting
Serious game program to help thinking skills in multiple sclerosis
This trial tests whether a computer “serious game” can improve thinking and memory skills in people with multiple sclerosis (MS). It’s designed for adults who report thinking problems and show weaker-than-average results on specific brain tests.
Arras, Hauts-de-FranceAges 18–65
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Common questions
- Are there clinical trials for progressive multiple sclerosis?
- Yes. Clin2 currently lists 133 recruiting progressive multiple sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a progressive multiple sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a progressive multiple sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Multiple Sclerosis, Secondary Progressive
- Multiple Sclerosis, Primary Progressive
- Multiple Sclerosis (MS) Primary Progressive
- Multiple Sclerosis (MS) Secondary Progressive
- Multiple Sclerosis, Chronic Progressive
- Multiple Sclerosis, Relapsing-Remitting
- Multiple Sclerosis (MS) - Relapsing-remitting
- Relapsing Multiple Sclerosis
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.