Clinical trials
Psychosis clinical trials
Below are recruiting psychosis clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05384392Recruiting
Blood and brain-marker study after a first psychotic episode
This study looks at whether special body and brain markers can predict how a person’s symptoms change over two years after a first psychotic episode. It may also help doctors understand who responds better to treatment, so future care can be more personalized.
AngersAges 15–30 - NCT05455593Recruiting
Water aerobics plus thinking-skills training for psychosis
This trial tests whether combining water aerobics with a structured “thinking-skills” program (metacognitive training) can improve symptoms and day-to-day functioning for certain people with psychosis. It may help by improving how you relate to thoughts and feelings while also adding supportive group exercise.
Sant Boi de Llobregat, BarcelonaAges 18–55 - NCT05550155Recruiting
TMS treatment to reduce voices in schizophrenia
This trial studies whether repeated noninvasive brain stimulation (TMS) can help reduce ongoing voice-hearing (auditory verbal hallucinations) in people with schizophrenia or schizoaffective disorder. It focuses on whether doing this after medication is already adjusted can improve symptoms and help keep them controlled.
CaenAges 18–65 - NCT05590637RecruitingPhase 4
Compare antipsychotic medicines for Parkinson or Lewy body psychosis
This study compares two medicines—quetiapine and pimavanserin—in people with psychosis caused by Parkinson’s disease or Lewy body dementia, looking at how they work over time. You might join if you are starting an antipsychotic for the first time and your clinician can safely manage either option.
San Antonio, TexasAges Any age - NCT05617898Recruiting
Study how social rewards work in early schizophrenia
This study looks at how your brain learns from positive social experiences in people who are in the early stages of schizophrenia-type illness. It may help researchers understand “social anhedonia” (feeling less pleasure or reward from social situations) and guide future treatments.
Birmingham, AlabamaAges 18–35 - NCT05703711Recruiting
MHealth plus nurse care for mental health in West Africa
This trial tests whether combining phone-based support (mHealth) with regular nurse-delivered care can improve outcomes for people with serious mental illness. You might benefit if you’re currently in an inpatient prayer camp and living with psychosis, mania, or depression.
AccraAges 18 years+ - NCT05847192Recruiting
Testing brain-signal networks in Alzheimer’s with hallucinations
This study looks at “tau” (a brain protein) and brain-signal patterns in people with Alzheimer’s disease who have psychotic symptoms like hallucinations or delusions. It may help researchers understand what’s happening in the brain and how to better target these symptoms.
Manhasset, New YorkAges 65–85 - NCT05962216Recruiting
Real-world check of Rexulti for schizophrenia and depression
This study looks at how well brexpiprazole (Rexulti) works in everyday treatment, and how people feel and function over time. You may be eligible if you’re newly started on Rexulti and have a qualifying mental health diagnosis.
Hong KongAges 18–65 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60 - NCT05995782RecruitingPhase 1
Testing safety of FB418 in healthy people
This trial studies a new drug called FB418 to see if it's safe and how the body handles it. It first tests single doses in younger healthy men, then multiple doses, and also includes an optional group for healthy older adults.
SeoulAges 19 years+ - NCT06048172Recruiting
Trauma therapy for PTSD with a psychotic disorder
This trial tests if prolonged exposure therapy, a common PTSD treatment, can help people who also have a psychotic disorder (like schizophrenia or bipolar with psychosis). The goal is to reduce PTSD symptoms.
HamburgAges 18 years+ - NCT06197048Recruiting
Nutrition counseling for schizophrenia or bipolar disorder
This study tests whether nutritional counseling can improve body measurements and health markers in people with schizophrenia, psychosis, or bipolar disorder. It may help you manage weight and overall health.
Drammen, AkershusAges 18 years+ - NCT06221852Recruiting
Ketogenic diet for first episode bipolar disorder
This study tests whether a special high-fat, low-carbohydrate diet (ketogenic diet) can help people who have recently been diagnosed with bipolar disorder. It may improve mood stability and overall brain health.
Belmont, MassachusettsAges 18–45 - NCT06257056Recruiting
Deep brain stimulation for hard-to-treat schizophrenia
This trial tests whether deep brain stimulation (a device that sends electrical pulses to specific areas of the brain) can help people with schizophrenia whose symptoms have not improved with standard treatments. If you have ongoing psychosis and have tried several medications without success, this study may be an option for you.
Dallas, TexasAges 22–70 - NCT07252206Recruiting
Culturally adapted CBT for Black people with psychosis
This study offers a talking therapy called culturally adapted cognitive behavioral therapy for psychosis (CBTp) for Black people in the UK who have schizophrenia or related conditions. It aims to see if this approach is helpful and acceptable, and you may join if you are over 16, identify with a Black background, and are not in a current crisis.
ManchesterAges 16 years+ - NCT06336382Recruiting
Tau protein study in late-onset psychosis
This study looks at brain proteins called tau in people who develop psychosis later in life (after age 60). Researchers want to understand how these proteins relate to symptoms, which may help find better treatments.
Manhasset, New YorkAges 65–85 - NCT06341517Recruiting
Brain circuit therapy for schizophrenia
This trial tests a noninvasive brain stimulation treatment (TMS) to improve symptoms of schizophrenia. It aims to target brain circuits that may be out of balance.
GenevaAges 18–65 - NCT06482554RecruitingPhase 3
Lumateperone for Apathy in Psychotic Disorders
This trial tests a medication called lumateperone to see if it can improve apathy (lack of motivation) in people who have psychotic symptoms from schizophrenia or related disorders. It may help if you are already on a stable treatment but still struggle with apathy.
Shreveport, LouisianaAges 18–65 - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT06586164Recruiting
Rehabilitation research for veterans with serious mental illness
This study is testing a new rehabilitation program for veterans with serious mental illness, like schizophrenia, bipolar disorder, or PTSD. If you join, you will help researchers see if this program improves daily functioning and quality of life.
San Diego, CaliforniaAges 18–83 - NCT06634641RecruitingPhase 4
Clozapine and immune function in Parkinson's disease
This trial tests whether clozapine, a medication for psychosis in Parkinson's disease, affects the immune system. It involves regular blood monitoring to help keep patients safe.
SalouëlAges 18 years+ - NCT06649552Recruiting
French validation of a psychosis risk questionnaire for teens
This study is testing a new French version of a questionnaire (SPI-CY) that helps doctors better understand early signs of psychosis in teenagers. If you are 12 to 17 and already being checked for these signs, you may be able to help improve the tool.
LilleAges 12–17 - NCT06687694Recruiting
How antipsychotics affect the immune system in psychosis
This study looks at how antipsychotic medicines affect the immune system in people with psychosis. By taking blood samples before and after starting or changing medication, researchers hope to understand why some people respond better to treatment.
London, United KingdomAges 18–65 - NCT06585787RecruitingPhase 3
Testing KarXT for psychosis in Alzheimer’s disease
This study tests an investigational medication (KarXT) for treating psychosis—hallucinations or delusions—in people with Alzheimer’s disease. It aims to see if the drug can reduce these symptoms safely and effectively.
Chandler, ArizonaAges 55–90
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Common questions
- Are there clinical trials for psychosis?
- Yes. Clin2 currently lists 145 recruiting psychosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a psychosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a psychosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.