Clinical trials
Serious Illness clinical trials
Below are recruiting serious illness clinical trials, each written for real people, not researchers. We’re tracking 36 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07009210Recruiting
Creating a personal legacy for people with serious illness
This study tests a program called Reflections: My Story that helps people with serious illness create a personal legacy—like a video, letter, or memory book—to share with loved ones. It aims to see if this support helps with emotional well-being.
Phoenix, ArizonaAges 18 years+ - NCT06880796Enrolling by invitation
Mindfulness therapy for serious mental illness
This trial tests whether mindfulness-based therapy helps people with serious mental illnesses like schizophrenia or mood disorders. You'll learn mindfulness skills in a group setting at your community mental health center.
Providence, Rhode IslandAges 18 years+ - NCT06586164Recruiting
Rehabilitation research for veterans with serious mental illness
This study is testing a new rehabilitation program for veterans with serious mental illness, like schizophrenia, bipolar disorder, or PTSD. If you join, you will help researchers see if this program improves daily functioning and quality of life.
San Diego, CaliforniaAges 18–83 - NCT06859060Recruiting
Improving health for people with serious mental illness
This study helps people with serious mental illness like schizophrenia or bipolar disorder who also have chronic health conditions (e.g., diabetes, overweight) get better overall care. It focuses on improving health and wellness through preventive medical care in Puerto Rico.
Mayagüez, Puerto RicoAges 21 years+ - NCT05807867Recruiting
Support program to help women with HIV keep treatment working
This study tests a stigma-reducing support program to help women living with HIV and serious mental illness stay adherent to HIV treatment. It focuses on sustaining viral suppression by addressing stigma that can make care harder, and it involves family and community leaders as part of the approach.
GaboroneAges 18–65 - NCT06865937Recruiting
A mobile app to help with social recovery in serious mental illness
This study tests a mobile app that provides support for social recovery in people with serious mental illness. It may help you feel less isolated and more connected.
San Diego, CaliforniaAges 18–65 - NCT07739004Recruiting
Fever in Children: Predictors of Serious Illness
This study looks at children with fever to find early signs that might predict serious illness, helping doctors make better triage decisions in the emergency room.
Kayseri, TalasAges birth–18 years - NCT07290478Enrolling by invitation
Helping You Choose a Health Care Proxy
This study helps you name someone to make health decisions for you if you can't. It's for older adults or people with serious conditions, and it aims to make this important choice easier.
Martinez, CaliforniaAges 18 years+ - NCT07224594Enrolling by invitation
Comparing palliative care models for seriously ill patients
This trial compares two ways of providing palliative care to hospitalized patients who are likely to pass away within the next year. It aims to see which approach better meets patients' needs and improves their quality of life.
Pasadena, CaliforniaAges 18 years+ - NCT06838689Recruiting
Comparing ways to involve people in pediatric, cancer, and serious illness research
This study compares two different methods for including patients, families, and clinicians in qualitative research about pediatric mental health, cancer screening, or serious illness. You can help by sharing your experiences and perspectives.
Hanover, New HampshireAges 18 years+ - NCT06630351Enrolling by invitation
Meaning-centered group therapy for caregiver wellbeing
This study tests whether group therapy focused on meaning and purpose can improve the wellbeing of people caring for someone with advanced cancer or another serious illness. Caregivers will join virtual group sessions and complete questionnaires about their feelings and stress.
Jacksonville, FloridaAges 18 years+ - NCT06596577Enrolling by invitationPhase 3
Improving access to specialty palliative care in hospitals
This trial tests if nudging healthcare providers can ensure that patients with serious illnesses receive the right kind of palliative care while in the hospital. It aims to make care more equitable and accessible.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05875805Recruiting
Telehealth planning for future care decisions
This trial tests a telehealth (video or phone) program that helps people with certain blood cancers plan their future care preferences. It may help you and your chosen support person communicate your wishes clearly, especially if you become too sick to speak for yourself.
Rochester, New YorkAges 60 years+ - NCT05040711Recruiting
Mindfulness app for serious illness patients and caregivers
This study tests whether a mindfulness training delivered through a phone or tablet can help people and their caregivers cope with serious illness. You may be eligible if you’re 60 or older (as a patient) or an adult caregiver, and if simple screening questionnaires suggest you could benefit.
Livingston, New JerseyAges 21 years+ - NCT07455526Recruiting
Help to quit smoking for veterans with mental illness
This program helps veterans who have a serious mental illness and use tobacco to get more support for quitting, such as connecting them with treatment options during their mental health visits.
Baltimore, MarylandAges Any age - NCT05703711Recruiting
MHealth plus nurse care for mental health in West Africa
This trial tests whether combining phone-based support (mHealth) with regular nurse-delivered care can improve outcomes for people with serious mental illness. You might benefit if you’re currently in an inpatient prayer camp and living with psychosis, mania, or depression.
AccraAges 18 years+ - NCT06370767Recruiting
Peer-assisted transportation study for adults with mental illness
This trial tests whether working with a peer helper can help adults with serious mental illness learn to use bikeshare and public transportation. You'll get support to travel more independently.
Philadelphia, PennsylvaniaAges 18–65 - NCT07529509Recruiting
Mental Health Support for Latino Adults in Connecticut
This study helps Latino adults in Connecticut who have serious mental health challenges and trauma but aren't currently in treatment. Researchers want to understand how to better engage and support this community.
New Haven, ConnecticutAges 18 years+ - NCT07518446Recruiting
Health Screening for Adults Starting Psychiatric Care
This study checks the physical health of adults beginning treatment for serious mental illnesses like schizophrenia or depression at two Danish clinics. It aims to catch health problems early that people with these conditions often experience.
CopenhagenAges 18 years+ - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT07312760Recruiting
Talking therapy for existential distress in advanced cancer
This trial compares a short-term psychodynamic therapy (ORPHYS) with usual care for people with advanced cancer who are struggling with existential distress, such as loss of hope, fear of death, or loneliness. It aims to see if this therapy can help improve emotional well-being.
DüsseldorfAges 18 years+ - NCT07264062Enrolling by invitation
MetSense pilot study for serious mental illness
This pilot study is testing a program for people with serious mental illness like schizophrenia or bipolar disorder. It aims to see if adding a special monitoring tool helps manage treatment better.
Pleasanton, CaliforniaAges 18 years+ - NCT07106385Recruiting
rTMS for better sleep in healthy adults
This study tests if a non-invasive brain stimulation method called rTMS can help improve sleep in adults who are generally healthy but have sleep complaints. If you are 18–65 and often have trouble sleeping, this might be a way to try a new approach without medication.
Hong Kong, Pok Fu LamAges 18–65 - NCT07106398Recruiting
Can brain stimulation reduce food cravings and help weight control?
This study tests whether a non-invasive brain stimulation technique called rTMS can help reduce food cravings and support weight control in adults who struggle with these issues but are otherwise healthy.
Hong Kong, Pok Fu LamAges 18–65
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Common questions
- Are there clinical trials for serious illness?
- Yes. Clin2 currently lists 36 recruiting serious illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a serious illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a serious illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.