Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 169 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04881084Recruiting
Digital stories to explore empathy and compassion
This study uses digital narratives (digital storytelling) to see how they may affect empathy and compassion. You may be asked to participate if you’re not currently in the hospital and haven’t already taken part in a specific prior workshop.
Montreal, QuebecAges 18–35 - NCT07692984Recruiting
Alcohol and drug use in people with schizophrenia or bipolar disorder
This study looks at how alcohol and substance use affects people with schizophrenia or bipolar disorder. It aims to understand if having these conditions together changes treatment or outcomes.
Bolu, BoluAges 18–65 - NCT05533749Recruiting
E-Health coaching to improve health habits in severe mental illness
This study tests an online (eHealth) program to help people with severe mental illness improve physical health and everyday lifestyle behaviors. If you’re eligible, you’ll be asked to use the internet program and complete questionnaires.
The Hague, South HollandAges 18–65 - NCT06315114Recruiting
Parenting support therapy for mental health
This study tests a talking therapy that helps parents with mental health challenges to better understand and connect with their child. It is designed for parents who are already getting help for conditions like anxiety, PTSD, or personality disorders.
Gentofte Municipality, Capital RegionAges 18–65 - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT06624462Recruiting
Meta Care Clinic for weight and health in severe mental illness
This study tests a special clinic that helps people with schizophrenia or bipolar disorder manage their weight and metabolic health while taking antipsychotic medication. It focuses on improving overall health with practical support.
Glostrup Municipality, Capital RegionAges 18–45 - NCT06628011Recruiting
Digital exercise follow-up for mental health patients
This trial tests whether a digital follow-up program with aerobic interval training can help people with mental disorders. You will use an app called HelsaMi to track your progress.
TrondheimAges 18–65 - NCT06677515Recruiting
Using VR to improve social skills in people with substance use and mental health issues
This study tests whether virtual reality (VR) training can help people with substance use and mental health disorders improve their social functioning. If you are getting treatment for substance use and can attend VR sessions twice a week for 5 weeks, you may be able to join.
BrumunddalAges 18–70 - NCT06789250Recruiting
Online therapy for mental health and alcohol use issues
This trial tests an internet-based cognitive behavioral therapy program designed for people who struggle with both mental health symptoms (like depression or anxiety) and problematic alcohol use. The goal is to see if this approach can help improve both issues at the same time, conveniently from home.
LinköpingAges 18 years+ - NCT06789380Recruiting
Generalist vs specialist care for severe personality disorders
This trial compares two types of treatment—generalist care by a therapist or specialist care—for people with severe personality disorders. It aims to find which approach works better and is more cost-effective.
Halsteren, North BrabantAges 18 years+ - NCT06904079Recruiting
AI-based rehab study for serious mental disorders
This study uses computer analysis and AI to predict how people with severe mental disorders might recover and to suggest better support. It may help improve rehabilitation plans tailored to each person.
ShanghaiAges 18–65 - NCT06914622Recruiting
Real-life recovery study for mental health
This study uses a smartphone app to track daily experiences, physical activity, and biological markers in people receiving treatment for a mental disorder. The goal is to understand how these factors relate to personal recovery.
BresciaAges 18 years+ - NCT07085923Recruiting
Heart health study for people with mental illness
This study tests a program to improve heart health in people with schizophrenia or bipolar disorder who take antipsychotic medication or lithium and have a high body weight. The goal is to help reduce heart disease risk.
OsloAges 25–70 - NCT07316803Recruiting
Group therapy for romantic relationships in young adults with mental illness
This study tests a group program to help young adults with serious mental health conditions build skills for romantic and social relationships. It may be a good fit if you are single, motivated to work on relationships, and have received mental health care recently.
Épinay-sur-Seine, Île-de-France RegionAges 18 years+ - NCT07339462Recruiting
Support program for mental illness recovery in South Africa
This study tests a new support program for people with serious mental illness (like schizophrenia or bipolar with psychosis) after a hospital stay. It includes their caregiver and focuses on helping them adjust to life back in the community.
Pietermaritzburg, KwaZulu-NatalAges 18 years+ - NCT07479758Recruiting
Brain scans and vision tests for severe mental illness
This study uses advanced MRI scans and visual perception tests to learn more about severe mental disorders like depression, schizophrenia, and bipolar disorder. It aims to improve diagnosis and treatment outcomes.
Hangzhou, ZhejiangAges 18–45 - NCT06804941Recruiting
Online CBT vs. usual care for common mental health issues
This study tests whether online cognitive behavioral therapy (CBT) works better than usual care for people with common mental health issues like anxiety, depression, or stress. If eligible, you would receive a guided online program from your computer or phone, without needing to visit a clinic.
Gustavsberg, Stockholm CountyAges 18 years+ - NCT06743711Recruiting
Heart fitness in severe mental illness study
This study checks how fit your heart and lungs are if you have a serious mental illness like schizophrenia or bipolar disorder. It aims to see if fitness can help improve health and well-being.
Glostrup MunicipalityAges 18–45 - NCT07360665Recruiting
Exercise program for people with psychosis on injectable meds
This trial tests a personalized exercise program for people with psychosis who take long-acting injectable antipsychotics. The goal is to see if regular physical activity can improve overall health and well-being.
Vila RealAges 18 years+ - NCT06511908RecruitingPhase 2
Testing a new ketamine-like drug for hard-to-treat depression
This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.
Bethesda, MarylandAges 18–70 - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT05704582Recruiting
Avatar vs supportive sessions to cut cannabis use
This study compares two types of talking/learning sessions—one using an “avatar” (computer-based character) and one using regular supportive sessions—to reduce cannabis use. It is meant for adults with psychotic disorders who also meet criteria for cannabis use disorder.
Montreal, QuebecAges 18 years+ - NCT06019247Enrolling by invitation
Job support program for people with mental illness
This study tests a program that helps people with serious mental illness find and keep competitive jobs. It provides individualized support to match you with employment that fits your goals.
New York, New YorkAges 18–60 - NCT03887559Recruiting
Group therapy for long-lasting trauma reactions in everyday clinics
This study tests a structured group program to help people manage long-lasting trauma-related symptoms such as feeling “on edge,” avoiding reminders, upsetting memories, strong emotions, or relationship problems. It may help you learn skills and stabilize symptoms while you continue care through regular outpatient clinics.
TrondheimAges 18–75
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Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 169 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.