Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04478838RecruitingPhase 4
Alternate-day antipsychotic dosing for schizophrenia
This trial looks at whether taking an antipsychotic every other day can keep symptoms controlled in adults with schizophrenia or another psychotic disorder. It may help some people avoid daily dosing, but it requires specific medication stability and screening checks.
Toronto, OntarioAges 18 years+ - NCT06717165Recruiting
Brain stimulation with talk therapy for OCD
This study tests if adding a gentle brain stimulation technique (tACS) to cognitive behavioral therapy (CBT) can help reduce OCD symptoms more than CBT alone. It is for adults with OCD who have not completed a full course of CBT before.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07836348Recruiting
Soteria-style ward versus standard psychiatric ward
This study compares a new type of psychiatric ward that uses a calm, home-like approach (Soteria) with a standard hospital ward. It aims to see if the Soteria-style environment helps men with acute psychosis recover better.
Jerusalem, JerusalemAges 18 years+ - NCT06942858Recruiting
Boosting therapy for anorexia with brain stimulation
This trial tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can help cognitive-behavioral therapy work better for people with anorexia nervosa. It aims to improve outcomes by targeting brain areas linked to thinking and behavior.
Shanghai, Shanghai MunicipalityAges 18–35 - NCT07829055Enrolling by invitation
Effects of mental tasks on breathing in chronic opioid users
This study looks at how doing mental tasks affects breathing in people who take opioids daily for chronic pain, compared to those with sleep apnea and healthy people. It may help understand how opioids affect breathing and improve safety.
San Diego, CaliforniaAges 45–65 - NCT07786714Recruiting
Faster brain stimulation for early psychosis risk
This study tests a faster type of brain stimulation, called accelerated neuromodulation therapy, in people who have early signs that could lead to psychosis. The goal is to see if this treatment can help reduce symptoms and improve daily life.
Verdun, QuebecAges 18–34 - NCT04539951RecruitingPhase 2
Trial for newly treated obsessive-compulsive disorder
This phase 2 study tests an OCD treatment strategy for people who have not yet had OCD medications or recent OCD therapy. It aims to reduce OCD symptoms, especially for those with moderate-to-severe symptom levels.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07214415RecruitingPhase 2
Hyperbaric oxygen therapy for veterans with brain injury or mental health issues
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and quality of life in veterans with mild traumatic brain injury, PTSD, anxiety, or depression. You must have already tried at least one evidence-based therapy like CBT or EMDR.
Boise, IdahoAges 18–75 - NCT07064629Enrolling by invitation
Virtual reality breathing training for anxiety
This trial tests if using virtual reality with biofeedback to practice relaxation breathing can help people with anxiety disorders. It aims to see if this method is more effective than standard techniques.
Klecany, Czech RepublicAges 18–65 - NCT06702761Recruiting
Depression among heart surgery healthcare workers in Baghdad
This study aims to find out how common and how severe depression is among healthcare workers in cardiothoracic surgery departments in Baghdad. It uses a questionnaire called PHQ-9 to screen for depression symptoms.
BaghdadAges 18 years+ - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT07212075Recruiting
Digital twin study for mental health in diabetes
This study uses digital twins—a virtual model of your health—to track how your mental health changes with diabetes. It aims to find patterns that could help personalize mental health care.
Bad Mergentheim, Baden-WurttembergAges 18–80 - NCT06942559Recruiting
Brain stimulation for treatment-resistant OCD
This trial tests a new type of brain stimulation (TMS) that is timed to your brain's natural rhythms, targeting a part of the brain linked to OCD. It may help people whose OCD has not improved with standard treatments.
Toronto, OntarioAges 18–65 - NCT07404085Recruiting
Boosting thinking skills with training and medication in mood or schizophrenia disorders
This study tests whether adding a medication that may improve brain flexibility makes memory and thinking training work better for people with bipolar disorder, recurring depression, or schizophrenia spectrum disorders. It could help improve daily thinking skills and quality of life.
Frederiksberg, Capital Region of DenmarkAges 35–75 - NCT06105853Recruiting
Stress and brain activity in alcohol use disorder
This study looks at how people with alcohol use disorder respond to stress and what happens in the brain. You'll use a smartphone and may have an MRI scan to understand your stress responses.
Mannheim, Baden-WurttembergAges 18–65 - NCT06457230Recruiting
Brain stimulation for methamphetamine use disorder
This study tests a new type of non-invasive brain stimulation (transcranial magnetic stimulation) that targets the cerebellum and prefrontal cortex to help people with methamphetamine use disorder. It aims to see if this treatment can reduce cravings and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT06505590Recruiting
Online support for cancer-related fatigue
This trial tests an online support program designed to help people with cancer manage fatigue. If you have had moderate to severe fatigue for at least a week, you may be able to join from home.
VillejuifAges 18 years+ - NCT01403402Recruiting
Study of congenital muscle disease patients and their families
This trial collects health information from patients with certain inherited (genetic) muscle diseases and from their families. It may help researchers better understand the disease and improve care by learning what symptoms and treatments patients experience over time.
Lakewood, CaliforniaAges Any age
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Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 164 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.