Clinical trials
Sickle Cell Crisis clinical trials
Below are recruiting sickle cell crisis clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06650813Recruiting
Adapting a fatigue program for sickle cell disease
This trial adapts the FACETS program, a fatigue-management course, for people with sickle cell disease. It aims to help participants better cope with fatigue and improve daily life.
GrenobleAges 18 years+ - NCT03976180Recruiting
High-flow oxygen for painful sickle cell episodes
This trial tests whether giving high-flow oxygen can help treat a painful sickle cell “vaso-occlusive crisis” (VOC) and lower the risk of a serious lung complication. You may be eligible if you’re an adult with sickle cell disease experiencing an opioid-requiring pain flare and have higher risk for lung trouble.
CréteilAges 18 years+ - NCT07188766Recruiting
Different IV fluid amounts for sickle cell pain crisis
This study compares two ways of giving IV fluids (lighter vs. more fluids) to adults with sickle cell disease who are in the hospital for a painful crisis. The goal is to see which approach helps you feel better sooner.
Dammam, Eastern ProvinceAges 18–60 - NCT06757829Recruiting
Lung function in sickle cell: testing Acu-TENS therapy
This study tests if a gentle electrical nerve stimulation treatment (called Acu-TENS) can help improve your lung function. It's for people with sickle cell disease who are not currently in pain or have other major health issues.
Dokki, Giza GovernorateAges 20–50 - NCT07432867RecruitingPhase 1/Phase 2
Gene therapy for severe sickle cell disease in teens and adults
This trial tests a new gene therapy for sickle cell disease. It uses your own blood stem cells (collected from bone marrow) that are modified in a lab to help produce healthy red blood cells, then given back to you after a short chemotherapy. The goal is to reduce or stop severe complications like pain crises and lung problems.
Paris, Île-de-France RegionAges 12–35 - NCT06035939Recruiting
SCD support study using mobile app
This trial tests a mobile app to help people with sickle cell disease manage their health. It's designed for those who have a compatible smartphone and internet access.
Charleston, South CarolinaAges 14–21 - NCT00081523Recruiting
Understanding How Sickle Cell Disease Develops Over Time
This research study follows people with sickle cell disease to learn how the condition affects their health over many years. By studying patients regularly, researchers hope to better understand the disease and improve care.
Washington D.C., District of ColumbiaAges 2–90 - NCT04925492RecruitingPhase 1
PET scan study for vaso-occlusive crises in sickle cell disease
This Phase 1 study uses a special scan (PET) to better understand what happens in vaso-occlusive crises (pain episodes) in sickle cell disease. It may help researchers find ways to track or predict these crises using imaging.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06464458Recruiting
Better hydroxyurea dosing for sickle cell patients
This trial checks whether monitoring hydroxyurea drug levels in the blood can help doctors find the best dose for sickle cell patients. It focuses on people with HbSS who have recently had a pain crisis or whose current dose isn't working.
StrasbourgAges 2–35 - NCT06260891RecruitingPhase 2
Zinc study for sickle cell disease and bone health
This study tests if taking zinc supplements can improve bone health in people with sickle cell disease. It's for those with certain types of sickle cell disease (SS or S-Beta zero thalassemia) who are not on chronic transfusions or zinc supplements.
Oakland, CaliforniaAges 15–40 - NCT07175051RecruitingPhase 2
Testing a kidney-protecting drug in sickle cell disease
This study tests whether empagliflozin, a medicine that protects the kidneys in people with diabetes, can also protect the kidneys in people with sickle cell disease. The goal is to see if it can reduce protein in the urine, which is a sign of kidney stress.
Chicago, IllinoisAges 18–60 - NCT06823219Recruiting
Long-term endurance training for sickle cell disease
This study tests whether a long-term endurance exercise program can improve physical fitness, reduce complications, and enhance quality of life for people with sickle cell disease. It is designed for patients whose condition is stable but who have had at least one pain crisis in the last three years.
CréteilAges 15 years+ - NCT05431088RecruitingPhase 2/Phase 3
Tested treatment for teens and adults with sickle cell pain crises
This study tests a treatment in people with sickle cell disease who are having repeated pain crises. It may help reduce the frequency of these crises and is tailored for certain ages and crisis patterns.
New Haven, ConnecticutAges 12 years+ - NCT06773715Recruiting
Virtual reality for pain from sickle cell disease
This study tests if using virtual reality (VR) can help children and teens with sickle cell disease feel better during a severe pain episode. You would use VR while in the hospital to see if it reduces your pain.
New Orleans, LouisianaAges 8–21 - NCT06300723Enrolling by invitation
BRL-101 for severe sickle cell disease
This trial tests a new treatment called BRL-101 for people with severe sickle cell disease. The treatment uses your own stem cells, which are modified in the lab and then given back to you. It aims to reduce pain crises and improve your quality of life.
Nanning, GuangxiAges 3–35
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Common questions
- Are there clinical trials for sickle cell crisis?
- Yes. Clin2 currently lists 39 recruiting sickle cell crisis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sickle cell crisis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sickle cell crisis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.