Clinical trials
Squamous Cell Carcinoma clinical trials
Below are recruiting squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 872 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07791745RecruitingPhase 2/Phase 3
Comparing treatments for advanced head and neck cancer
This trial tests a new combination of treatments for head and neck cancer that has returned or spread and can't be cured with local therapy. It compares a standard chemotherapy with or without an additional drug to see which is more effective and safe.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06377735Recruiting
BAI-BACE for advanced lung squamous cell carcinoma
This trial is testing a new use of a procedure called BAI-BACE (injecting drugs or blocking blood flow through the bronchial artery) for people with advanced lung squamous cell carcinoma that hasn't responded to prior treatments. The goal is to see if this treatment can help control the cancer when it's still only in the chest.
Beijing, Beijing MunicipalityAges 18–80 - NCT07781072RecruitingPhase 2
Immunotherapy plus radiation for advanced head and neck cancer
This trial tests a combination of an immunotherapy drug (sintilimab) with radiation and chemotherapy for people with advanced head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT06007729RecruitingPhase 2
A study of HS-20093 for head and neck cancer and other solid tumors
This trial tests a new drug, HS-20093, in people with head and neck squamous cell carcinoma or other solid tumors that have worsened after standard treatments. The goal is to see if the drug can help shrink or slow the growth of these cancers.
Hefei, AnhuiAges 18 years+ - NCT06563869RecruitingPhase 3
Sintilimab with chemo and growth factor before esophageal cancer surgery
This trial tests whether giving the immunotherapy drug sintilimab together with standard chemotherapy and a growth factor injection before surgery can help people with a certain type of esophageal cancer (squamous cell carcinoma) that is still removable. The goal is to improve treatment outcomes before the operation.
Nanjing, JiangsuAges 18–75 - NCT07768189RecruitingPhase 3
Testing CRB-701 for throat cancer that returned
This study tests an investigational drug called CRB-701 to see if it can help people with a certain type of throat cancer that has not responded to standard treatments. The trial compares CRB-701 to a doctor's choice of other available treatments.
Huntsville, AlabamaAges 18 years+ - NCT07773688Recruiting
Microscopy study of skin biopsy samples
This study uses a special microscope to look at skin biopsy samples in more detail. It may help doctors understand skin conditions better and improve future diagnoses.
Victor, New YorkAges Any age - NCT06575322Recruiting
Neoadjuvant therapy for head and neck cancer: effects on pain and mood
This trial tests whether adding immunotherapy to chemotherapy before surgery can help reduce pain, anxiety, and depression in people with head and neck cancer. The goal is to see if this approach improves quality of life during treatment.
Guanzhou, GuangdongAges 18–80 - NCT07751341RecruitingPhase 2
New drug with chemotherapy for advanced esophageal cancer
This study tests a new drug (SHR-9839) alone or combined with standard chemotherapy and another immunotherapy drug (adebrelimab) for advanced esophageal cancer. The goal is to see if this combination helps shrink tumors or slow cancer growth better than the standard treatment.
Beijing, Beijing MunicipalityAges 18–75 - NCT06137378RecruitingPhase 2
Pembrolizumab for advanced throat cancer to avoid laryngectomy
This trial tests whether a drug called pembrolizumab (Keytruda) can help people with advanced throat cancer avoid removal of the voice box. You may be eligible if you have a specific type of larynx or hypopharynx cancer that hasn't been treated with radiation or immunotherapy before.
Mannheim, Baden-WürtembergAges 18–70 - NCT05014464RecruitingPhase 2
Testing ALK-targeted pills for ALK-positive advanced squamous cancer
This Phase 2 study tests whether ALK-targeted drugs can shrink or control advanced squamous cell cancer that has spread. You may be eligible if your tumor has an ALK gene rearrangement and you have not had prior cancer medicines for this stage.
Changsha, HunanAges 18 years+ - NCT05797415Recruiting
Check sentinel lymph node biopsy for several eye skin cancers
This trial studies whether a “sentinel lymph node biopsy” can better detect cancer spread in people with specific cancers of the eye surface and nearby tissues. It may help doctors find the right next treatment by learning whether lymph nodes are involved.
Roma, RomeAges 18–95 - NCT05495152RecruitingPhase 3
Sintilimab after esophageal surgery to help prevent cancer return
This trial looks at adding sintilimab (an immunotherapy) after surgery for certain stages of esophageal squamous cell cancer. The goal is to lower the chance the cancer comes back after standard treatment.
Zhengzhou, HenanAges 18–70 - NCT07733180RecruitingPhase 2
Study of tislelizumab plus chemo for advanced esophageal cancer
This trial tests different schedules of tislelizumab (an immunotherapy drug) combined with chemotherapy for Japanese patients with advanced esophageal squamous cell carcinoma that cannot be removed by surgery or has spread. It aims to find a better way to give these treatments together.
Yokohama, KanagawaAges 18 years+ - NCT05286619RecruitingPhase 2
Pembrolizumab with chemotherapy for recurrent head and neck cancer
This trial studies whether pembrolizumab plus chemotherapy (platinum and gemcitabine) can control recurrent or metastatic head and neck squamous cell carcinoma that can’t be cured with local treatments. It may help shrink tumors and slow disease growth in people who haven’t had cancer medicines for this stage before.
Kuala LumpurAges 18 years+ - NCT07700667RecruitingPhase 2
Testing a new drug combo for advanced esophageal cancer
This trial tests a new drug combination (SKB500 plus other treatments) for people with advanced esophageal squamous cell carcinoma. It aims to see if the combination is safe and effective for those who have had little or no prior treatment.
ChangchunAges 18–75 - NCT07699185RecruitingPhase 2
Immunotherapy plus chemoradiation before surgery for esophageal cancer
This study tests whether giving a combination of chemotherapy, radiation, and an immunotherapy drug (cadonilumab) before surgery can help shrink esophageal cancer and improve outcomes. It is for people with a specific type of esophageal cancer that has not spread to other parts of the body.
Wuhan, HubeiAges 18–75 - NCT07690618RecruitingPhase 1
Heat therapy for head and neck cancer
This phase 1 trial tests adding heat therapy (thermotherapy) to standard radiation (with or without chemo) for head and neck cancer. It aims to see if it is safe and effective for patients with locally advanced disease who have not had radiation before.
Rotterdam, South HollandAges 18 years+ - NCT07692152RecruitingPhase 3
Immunotherapy vs. chemo for MS anal cancer trial
This trial tests sintilimab (a type of immunotherapy) against mitomycin plus chemotherapy with radiation for anal cancer that hasn't spread. It aims to find a better treatment with fewer side effects.
Beijing, Beijing MunicipalityAges 18–75 - NCT07682831Recruiting
Studying skin biopsies with advanced microscopy
This trial uses a special microscope to look at skin biopsy samples in new ways. It may help doctors understand skin conditions better without needing extra procedures.
Victor, New YorkAges Any age - NCT06675201RecruitingPhase 2
Personalized vaccine for advanced esophageal cancer after treatment
This trial tests a personalized vaccine made from your tumor's unique markers (neoantigens) to help prevent your advanced esophageal cancer from coming back. It's for people who have already completed strong treatment and are currently cancer-free, but have a high risk of recurrence.
Chengdu, Please SelectAges 18–80 - NCT07665190RecruitingPhase 2
New drug combination before surgery for advanced throat cancer
This trial tests a new combination of a targeted therapy (EGFR-ADC) and an immunotherapy drug before surgery to shrink and control locally advanced throat cancer. It may help make surgery more effective and reduce the chance of recurrence.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07659678RecruitingPhase 2
Pet scan for head and neck cancer
This study tests a special PET/CT scan that may help doctors see the cancer more clearly in people with head and neck cancer, either at diagnosis or if it comes back.
St Louis, MissouriAges 18 years+ - NCT06684600RecruitingPhase 2
Treating advanced esophageal cancer with dalpiciclib and pyrotinib
This trial tests a combination of two targeted drugs (dalpiciclib and pyrotinib) for people with advanced esophageal squamous cell carcinoma whose cancer has gotten worse during or after first chemotherapy. The goal is to see if this drug pair can help shrink tumors or slow the disease.
Beijing, Beijing MunicipalityAges 18–75
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Common questions
- Are there clinical trials for squamous cell carcinoma?
- Yes. Clin2 currently lists 872 recruiting squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.