Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 221 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07365293Recruiting
Support for Families Affected by Opioid or Meth Use
This study tests a program that helps parents who are using opioids or methamphetamines get support for themselves and their families. It may be a good fit if you have Medicaid, live in certain counties, and are open to working with a coach.
Eugene, OregonAges Any age - NCT07378254Recruiting
Emotional strength program for Black young adults
This study tests a program designed to help Black young adults build emotional strength after a traumatic experience. It aims to see if the program can improve well-being and resilience.
Piscataway, New JerseyAges 18–35 - NCT07387796Recruiting
Brain and behavior changes with tirzepatide stop and restart
This study looks at how your brain and behavior change when you stop and then restart the weight loss drug tirzepatide. It will help researchers understand what happens during treatment breaks.
Dallas, TexasAges 18–70 - NCT07433985Recruiting
California mobile app study for men after jail release
This study tests a mobile app to help men recently released from jail or prison who use drugs or have sex with men stay healthy and avoid HIV. It's for people who don't have HIV and live in certain California counties.
Oakland, CaliforniaAges 18–59 - NCT07505875Recruiting
Study to create transgender-friendly services for chemsex support
This study aims to develop healthcare services tailored to transgender people regarding chemsex (using drugs during sex). Researchers will interview participants to understand their needs and experiences.
Pathum Wan, BangkokAges 18 years+ - NCT07512869Recruiting
Harm Reduction Support for Men Who Have Sex With Men in Bangkok
This study explores ways to support men who have sex with men (MSM) in Bangkok who use drugs during sexual activities, called 'chemsex.' Researchers want to understand how community leaders, healthcare workers, and police can work together to keep people safer and healthier.
Pathum Wan, BangkokAges 18 years+ - NCT07595614Recruiting
Weekly Writing to Track Recovery Progress in Substance Use
This study asks men in residential treatment for substance use to write weekly reflections about their recovery. Researchers will analyze these writings to better understand how people progress through treatment and improve how clinicians support recovery.
Potrerillos, JaliscoAges 18 years+ - NCT07130500Enrolling by invitation
Rewards for sticking with long-acting injections
This study tests whether offering small rewards (like gift cards) can help people stick with a long-acting injection of their medication. It's for people with serious mental health conditions who have had a recent hospital stay or are at high risk of one.
Pittsburgh, PennsylvaniaAges 18–65 - NCT07104396Recruiting
Study on developing digital treatments for addiction
This trial is looking for experienced scientists (with a PhD or MD) who study substance use disorders and are interested in testing or developing new digital treatments (like apps or computer programs). It's a chance to help create better digital tools for addiction recovery.
Hanover, New HampshireAges 18 years+ - NCT06863909Enrolling by invitation
Journaling plus cognitive behavioral therapy for better results
This trial explores whether adding journaling to your regular cognitive behavioral therapy sessions helps you feel better more quickly. You keep seeing your therapist as usual, just add a few minutes of writing each day.
TübingenAges 18–65 - NCT05626374Enrolling by invitation
Remote check-in tool to reduce dropout in training
This study tests whether adding a remote, self-report tool for distress (how overwhelmed or unwell someone feels) improves how many people complete a vocational training program. It’s meant to support people using the usual case management, but with extra remote check-ins.
Barrie, OntarioAges 18–49 - NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+ - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+ - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT06675539Recruiting
Testing a tool to predict alcohol withdrawal severity in French speakers
This study tests a French version of a questionnaire (PAWSS) that helps doctors predict how severe alcohol withdrawal might be. It is for people aged 18 to 60 who are dependent on alcohol and planning a supervised detox or being hospitalized for another reason.
ÉtampesAges 18–60 - NCT05570708Enrolling by invitation
Therapist training trial on how experience shapes therapy
This study looks at how therapists’ personal experience affects their attitude and skills during substance-assisted therapy training. It’s mainly for therapists-in-training, and may help improve how future training and therapy are delivered safely.
BaselAges 27 years+ - NCT05886582RecruitingPhase 2
Rotigotine patch added to therapy for cocaine use
This Phase 2 study tests whether a rotigotine skin patch, used alongside behavioral therapy, can help people reduce cocaine use. It also looks at changes in brain activity while you do study tasks.
Richmond, VirginiaAges 25–70 - NCT06550167Recruiting
Nano PSO for brain protection in substance users
This trial tests whether a supplement called Nano PSO can help protect the brain in people who have used methamphetamines, cocaine, and cannabis for at least three years. It looks at effects during the withdrawal period for men currently in residential treatment.
Guadalajara, JaliscoAges 18–50 - NCT05679284Recruiting
Study for retained needle fragments in people who inject drugs
This observational study looks at whether small pieces of drug-injection needles remain in injection sites. You may help by answering a questionnaire and getting X-ray images, which could improve how care and safety are handled for people who inject drugs.
TampereAges 18 years+ - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT07056894Recruiting
Cognitive training for substance use in early psychosis
This study tests a computer-based cognitive training program to help people with early psychosis reduce their alcohol and cannabis use. The program is designed to improve thinking skills and may make it easier to cut back on substance use.
St. John's, Newfoundland and LabradorAges 16–30 - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+ - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75
Hear when a new Substance Use trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 221 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.