Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05743699Recruiting
Bright Horizons program for Native teens with recent binge drinking
This study tests the Bright Horizons program to help Native American youth who recently had a binge alcohol event. It looks at whether support and skills can reduce risky drinking and improve safety and wellbeing.
Whiteriver, ArizonaAges 10–24 - NCT05700474Recruiting
Wellness support program for people with HIV or prevention needs
This trial tests an education and support program to improve overall wellness for adults who have HIV or are seeking HIV prevention services. It also looks at people who have had alcohol or substance use recently.
Charlotte, North CarolinaAges 18 years+ - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT05626374Enrolling by invitation
Remote check-in tool to reduce dropout in training
This study tests whether adding a remote, self-report tool for distress (how overwhelmed or unwell someone feels) improves how many people complete a vocational training program. It’s meant to support people using the usual case management, but with extra remote check-ins.
Barrie, OntarioAges 18–49 - NCT05562557Recruiting
Fatherhood program to improve outcomes and support families
This study partners with fathers to help improve family outcomes, especially when there are worries about substance use in the household. You may be able to join if you are a father caregiver and your family has an identified risk for substance use, and you speak English or Spanish.
The Bronx, New YorkAges 18 years+ - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT05541406Recruiting
School support program for LGBTQ high school students
This trial is testing a program designed to make high schools more supportive for LGBTQ students. It aims to see if the program improves the school experience and well-being of LGBTQ youth.
El Monte, CaliforniaAges 12–20 - NCT05327504Recruiting
Writing therapy for PTSD and substance use in veterans
This study tests a structured “written exposure” therapy to help veterans with PTSD who also have a substance use disorder (SUD). It may help reduce PTSD symptoms while also supporting safer, more stable recovery.
West Haven, ConnecticutAges 18 years+ - NCT05156112Recruiting
Sleep apnea treatment for veterans with PTSD and substance use
This study tests whether treating sleep apnea with a breathing device during a residential program helps veterans with post-traumatic stress disorder (PTSD) and substance use problems. It aims to improve their recovery and quality of life.
San Diego, CaliforniaAges 18 years+ - NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+ - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+ - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT06675539Recruiting
Testing a tool to predict alcohol withdrawal severity in French speakers
This study tests a French version of a questionnaire (PAWSS) that helps doctors predict how severe alcohol withdrawal might be. It is for people aged 18 to 60 who are dependent on alcohol and planning a supervised detox or being hospitalized for another reason.
ÉtampesAges 18–60 - NCT05570708Enrolling by invitation
Therapist training trial on how experience shapes therapy
This study looks at how therapists’ personal experience affects their attitude and skills during substance-assisted therapy training. It’s mainly for therapists-in-training, and may help improve how future training and therapy are delivered safely.
BaselAges 27 years+ - NCT06550167Recruiting
Nano PSO for brain protection in substance users
This trial tests whether a supplement called Nano PSO can help protect the brain in people who have used methamphetamines, cocaine, and cannabis for at least three years. It looks at effects during the withdrawal period for men currently in residential treatment.
Guadalajara, JaliscoAges 18–50 - NCT05679284Recruiting
Study for retained needle fragments in people who inject drugs
This observational study looks at whether small pieces of drug-injection needles remain in injection sites. You may help by answering a questionnaire and getting X-ray images, which could improve how care and safety are handled for people who inject drugs.
TampereAges 18 years+ - NCT07148843RecruitingPhase 2/Phase 3
CBD for alcohol withdrawal and cravings
This study tests whether adding CBD (a cannabis compound that doesn't get you high) to usual care can help reduce alcohol withdrawal symptoms and cravings. It may offer a new way to support people trying to cut down or stop drinking.
Baltimore, MarylandAges 21–65 - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT07056894Recruiting
Cognitive training for substance use in early psychosis
This study tests a computer-based cognitive training program to help people with early psychosis reduce their alcohol and cannabis use. The program is designed to improve thinking skills and may make it easier to cut back on substance use.
St. John's, Newfoundland and LabradorAges 16–30 - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+ - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT07342504Recruiting
Brief alcohol support for people on buprenorphine
This trial tests a brief alcohol-focused support program designed for people who are already taking buprenorphine for opioid addiction. The goal is to help you reduce your drinking in a way that fits with your current treatment.
Notre Dame, IndianaAges 18 years+ - NCT07354152Recruiting
Flap vs skin graft for melanoma wound closure
This study compares two ways of closing a large wound after melanoma removal: using a skin flap (where nearby tissue is moved to cover the defect) versus a skin graft (taking a thin layer of skin from another area). It aims to see which method works better for healing.
Nantes, NantesAges 18 years+ - NCT07665502Enrolling by invitation
Smartphone app to boost opioid treatment for women facing violence
This study tests a smartphone app (WINGS+++) to help women who have experienced intimate partner violence and trauma improve their engagement with medication for opioid use disorder (MOUD). The goal is to see if the app makes it easier to start and stay on treatment.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 218 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.