Clinical trials
Syphilis clinical trials
Below are recruiting syphilis clinical trials, each written for real people, not researchers. We’re tracking 28 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07089836Recruiting
Syphilis blood test study for at-risk and healthy people
This study tests two new blood tests for syphilis. It compares them to approved tests using blood from people who may have or had syphilis, including pregnant women, HIV-positive people, and healthy volunteers.
Lancaster, CaliforniaAges 13 years+ - NCT07830550Enrolling by invitation
Blood donation study for a syphilis test
This study is collecting blood samples from healthy adults to help develop a new test for syphilis, an infection that can be spread through sex. If you are willing to give a small blood sample, you may be able to join and help improve testing.
Salem, New HampshireAges 22 years+ - NCT07358949Recruiting
Rapid syphilis test for family planning patients in Hawai'i
This study tests a quick syphilis test for people getting birth control or abortion services. It aims to see if the test is easy to use and helpful in a clinic setting.
Honolulu, HawaiiAges 14 years+ - NCT06645106Recruiting
Rapid syphilis testing for pregnant patients in the ER
This trial offers quick, on-the-spot syphilis testing for pregnant people who come to the emergency department or obstetrical triage and haven't had prenatal care or a syphilis test yet during this pregnancy. It aims to make testing easier and faster so you can get care if needed.
Houston, TexasAges 18–50 - NCT06586905Recruiting
A study of a new syphilis test at an Ottawa sexual health clinic
This study tests a new rapid syphilis test (Multiplo® Complete Syphilis) that can be done at a clinic. It aims to see how well it detects infectious syphilis compared to standard lab tests. You might help if you are getting syphilis testing at the clinic.
Ottawa, OntarioAges 16 years+ - NCT06082453Recruiting
Modernizing syphilis testing in pregnancy and beyond
This study is testing a new, faster way to check for syphilis in pregnant people, new mothers, and their newborns, as well as in men and non-pregnant people at a Harris Health clinic. The goal is to make sure more people get the right treatment quickly.
Los Angeles, CaliforniaAges Up to 45 years - NCT07317687Recruiting
Rapid HIV, Hep C, and Syphilis Testing in Street Medicine
This trial offers free rapid testing for HIV, hepatitis C, and syphilis during street medicine visits. It helps find infections early so you can get connected to care.
Harpers Ferry, West VirginiaAges 18 years+ - NCT07300254Recruiting
Syphilis shedding study in women and men who have sex with women only
This study looks at how syphilis bacteria are shed from the body in people with early syphilis. It aims to understand how the infection might spread, especially among women and men who have sex only with women.
Melbourne, VictoriaAges 18 years+ - NCT07189208RecruitingPhase 2
Preventing syphilis during pregnancy
This study tests whether taking an antibiotic (penicillin) during pregnancy can prevent syphilis infection in women who are at higher risk. If you are pregnant and have certain risk factors, this trial may help keep you and your baby safe from syphilis.
Duque de Caxias, Rio de JaneiroAges 18–45 - NCT07170748Recruiting
Testing a new blood test for HIV, hepatitis B/C, and syphilis
This study evaluates a new blood test that checks for HIV, hepatitis B, hepatitis C, and syphilis all at once. It is designed to see how well the test works in different groups of people, including those with known infections and those without.
AbidjanAges 18 years+ - NCT06921213RecruitingPhase 2
Oral antibiotics for newborns exposed to syphilis
This study tests whether giving oral antibiotics at home is as safe and effective as the usual injections for newborns exposed to syphilis during pregnancy. It is for babies who appear healthy at birth.
JakartaAges birth–1 week - NCT06829602Recruiting
Syphilis testing during pregnancy for those facing barriers
This study tests if a quick syphilis test (done right in the clinic) can help pregnant people who may have trouble getting regular care. It aims to catch syphilis early so both you and your baby can get treatment if needed.
Hamilton, OntarioAges 13–49 - NCT06428643Recruiting
Chlamydia prevention program for young Black adults in New Orleans
This study tests a program to help reduce chlamydia infections in young Black or African American people in New Orleans. It involves testing for chlamydia and then providing treatment or prevention support.
New Orleans, LouisianaAges 15–26 - NCT06069141Recruiting
Comparing syphilis treatments for people with HIV
This study compares the standard treatment for early syphilis with a combination that includes an extra antibiotic, to see which is more effective. It is for people living with HIV who have early syphilis.
Hsinchu, TaiwanAges 18 years+ - NCT05326061Recruiting
Study for people at high risk of getting HIV
This registry study looks at people who are HIV-negative but at high risk of getting HIV, to better understand risk and care needs. If you qualify, you may be asked to share health and behavior information to help guide future prevention efforts.
ViennaAges 18–100 - NCT03418441Recruiting
Study infections of the brain and spinal fluid in Denmark
This trial focuses on people in Denmark who may have an infection in the brain or the fluid around the brain and spinal cord. Researchers aim to collect and compare diagnostic results for different infection types (viral meningitis, bacterial meningitis, encephalitis, and others) to help confirm the cause and guide care.
AalborgAges 18 years+ - NCT07563309Recruiting
Testing a new rapid HIV, hepatitis B, and syphilis test
This study evaluates a new rapid blood test that checks for HIV, hepatitis B, and syphilis all at once. Researchers want to make sure the test works well, is easy to use, and gives accurate results.
Johannesburg, GautengAges 18 years+ - NCT07500415Recruiting
Doxycycline to prevent STIs in Rio de Janeiro
This trial tests whether taking the antibiotic doxycycline can prevent sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in people at higher risk. If you are a man or transgender woman who has sex with men, are living with HIV or on PrEP, and have had an STI in the past year, you may be able to join.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07397403RecruitingPhase 4
Doxycycline to prevent STIs in men who have sex with men
This trial tests whether taking a single dose of doxycycline after sex can prevent common sexually transmitted infections (STIs) like gonorrhea, chlamydia, and syphilis in men who have sex with men (MSM) in Bangkok.
Sathorn, BangkokAges 3 weeks–2 months - NCT06391125RecruitingPhase 3
Lidocaine for pain relief with penicillin shot for syphilis
This study tests if adding a numbing medicine (lidocaine) to a penicillin shot reduces the pain of the injection for people being treated for syphilis. If you are starting your first of three weekly penicillin shots, you may be able to join.
St Louis, MissouriAges 18 years+ - NCT06996938Recruiting
Sexual health screening for women in vulnerable situations
This study offers sexual health checkups and prevention services to women who are in difficult social or financial situations, including those without stable housing or who have sold sex for money. The goal is to see if these services are helpful and acceptable.
ParisAges 18 years+ - NCT06683638RecruitingPhase 2
Daily doxycycline for early syphilis treatment
This trial tests if taking a daily antibiotic (doxycycline) for two weeks can treat early syphilis in adults. It may help people who have been diagnosed with primary, secondary, or early latent syphilis.
Seattle, WashingtonAges 18 years+ - NCT06791928Enrolling by invitationPhase 2
HIV and syphilis self-testing study for men who have sex with men
This study tests whether giving at-home HIV and syphilis self-test kits to men who have sex with men (MSM) can help more people learn their status and get linked to care. It also looks at how sharing test results with partners might increase testing and prevent the spread of infections.
WakisoAges 18–65 - NCT06738407RecruitingPhase 4
Doxycycline to prevent STIs in high-risk people
This study tests whether taking a daily antibiotic (doxycycline) can prevent sexually transmitted infections in people at high risk. If you've had an STI recently and sometimes have sex without condoms, you might be able to join.
Los Angeles, CaliforniaAges 13–29
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Syphilis trials by city
Studies with a site in or near these metro areas.
Syphilis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for syphilis?
- Yes. Clin2 currently lists 28 recruiting syphilis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a syphilis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a syphilis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.