Clinical trials
Tobacco Smoking clinical trials
Below are recruiting tobacco smoking clinical trials, each written for real people, not researchers. We’re tracking 113 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07710820Recruiting
Can a heated tobacco product help you stop smoking?
This study tests whether having access to a heated tobacco product (a device that heats tobacco, not burns it) helps current cigarette smokers quit smoking. You'll try four different flavors over a week and then continue using one you like.
Brandon, FloridaAges 21–65 - NCT05627674Enrolling by invitation
Help improve lung cancer screening and quitting support uptake
This study tests a “precision” approach to help people who are newly eligible for lung cancer screening actually get screened and start smoking-cessation treatment. If it works, it could make screening and quitting help easier to access and more engaging.
St Louis, MissouriAges 18 years+ - NCT06932276Recruiting
Smoke-free homes study for families with kids
This study tests a program to help families make their homes smoke-free, especially when there are children and smokers living together. It aims to reduce secondhand smoke exposure for kids.
Barcelona, CataloniaAges 18 years+ - NCT05572671Recruiting
Study brain scans to predict near-term smoking relapse risk
This study uses MRI brain scans and smoking measurements to understand what may predict when someone is about to smoke again. If you qualify, you’ll be asked to avoid nicotine for 12 hours before a lab visit and complete MRI safety screening.
University Park, PennsylvaniaAges 21–65 - NCT06438549Recruiting
Community health workers help pregnant smokers quit
This study tests whether adding a community health worker to your prenatal care team can help pregnant women quit smoking. It's for women who are ready to make a quit plan and are getting care at certain hospitals.
Loma Linda, CaliforniaAges 18 years+ - NCT06166433Recruiting
Smoke-free home program in Armenia and Georgia
This study tests a program to help people make their homes smoke-free. If you smoke indoors or live with someone who does, and you speak Armenian or Georgian, this may help protect your family from secondhand smoke.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06966362RecruitingPhase 4
Help cutting back on smoking for veterans not ready to quit
This study tests a medicine called varenicline (also known as Chantix) to help veterans who aren't ready to quit smoking yet but want to cut down. The goal is to see if it helps reduce how much they smoke.
San Diego, CaliforniaAges 21 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05836103Recruiting
Texting on your phone to help you quit smoking
This trial tests whether smartphone texting messages can help young adults stop smoking. If you’re planning to quit soon, the messages may support you during the quitting process.
Baltimore, MarylandAges 18–30 - NCT07301151Recruiting
Quit smoking study for Black adults in Minnesota
This study tests a smartphone app to help Black adults in Minnesota who smoke quit smoking. You'll use the app to track your progress and get reminders.
Minneapolis, MinnesotaAges 21 years+ - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06651684Recruiting
Quit smoking help for parents with social needs
This trial tests if health navigators can help parents who smoke and have unmet social needs to quit smoking. If you smoke and face challenges like trouble paying bills or finding childcare, this program may support you.
Montreal, QuebecAges 18 years+ - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT06873009Enrolling by invitation
Can therapy help men in prison quit smoking?
This trial tests if cognitive behavioural therapy (a type of talk therapy that changes thinking and habits) can help men in prison stop smoking. It aims to see what works best and for whom.
Paris, Île-de-France RegionAges 18 years+ - NCT06609369RecruitingPhase 2
Sleep and smoking relapse study
This study tests whether improving sleep can help people quit smoking and avoid relapse. It uses brain scans, a quitting medication, and counseling.
New Haven, ConnecticutAges 18–65 - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05859451Recruiting
Heated tobacco product study for surgically treated leg fractures
This study looks at whether a tobacco heating system (instead of cigarettes) affects how well a surgically repaired tibia or femur fracture heals. It mainly targets smokers with a certain smoking history who do not want to join free smoking-cessation seminars.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07576595Recruiting
Lung Cancer Screening and Quit-Smoking Support for African Americans
This study helps African American smokers get lung cancer screening and receive support to quit smoking. Researchers will provide guidance and resources tailored to help you stop smoking and catch lung disease early if needed.
New Orleans, LouisianaAges 50–80 - NCT07489443Recruiting
Helping pregnant women reduce tobacco and cannabis use
This study is testing a program to help pregnant women and new mothers cut back on or quit using tobacco and cannabis. It’s designed to see if the program is easy to use and helps improve health for both mom and baby.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07568483Recruiting
Web-based smoking cessation support program
This study tests TUBSIS 2.0, a digital program designed to help you quit or cut back on smoking. You'll use it on your computer, tablet, or phone, and researchers will track how it affects your smoking habits over time.
ZurichAges 18 years+ - NCT07236580Recruiting
Breathing exercises for teens with ear problems and smoke exposure
This study tests whether special breathing exercises can help teenagers with a blocked eustachian tube (the tube that connects the ear to the throat) whose parents smoke. It aims to improve ear and lung function.
Giza, DokkiAges 13–17 - NCT07162935Recruiting
Cigarillo use study for young adults
This study looks at how young adults use cigarillos. You will smoke research cigarillos in a lab and answer questions. The goal is to understand cigarillo use to help with future regulation.
Oklahoma City, OklahomaAges 18–24
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Common questions
- Are there clinical trials for tobacco smoking?
- Yes. Clin2 currently lists 113 recruiting tobacco smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.