Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 159 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05868421Recruiting
Veteran coaching with a trusted person to quit smoking
This study tests whether involving a supportive family member or friend can help a veteran use smoking-quit treatment more effectively. If you’ve smoked recently and can name a trusted contact who will join, you may be able to participate.
Minneapolis, MinnesotaAges 18 years+ - NCT07111936Recruiting
Using CONNECT to help multilingual smokers get lung cancer screening
This study tests a program called CONNECT to help current smokers aged 50-80 get lung cancer screening. It aims to see if the program works well for people who speak different languages.
San Francisco, CaliforniaAges 50–80 - NCT06584929Recruiting
Rural smoking cessation app study
This study tests a smartphone-based program to help people who smoke at least 5 cigarettes a day quit. It focuses on adults in rural areas who want to stop smoking using their own device.
Minneapolis, MinnesotaAges 21 years+ - NCT06357767Recruiting
Quit Smoking Program for American Indian Women
This study tests a program to help American Indian women who smoke and have recently experienced abuse from a partner quit smoking. It focuses on women in the Rapid City area and offers support to quit.
Rapid City, South DakotaAges 18 years+ - NCT06098144RecruitingPhase 4
Smoking cessation program for construction workers
This study tests a program to help construction workers quit smoking. It involves safety managers receiving training to support workers in their quit attempts.
Miami, FloridaAges 18 years+ - NCT05764759Recruiting
Help with quitting smoking using phone and primary care support
This study tests a new way to help people quit smoking in rural primary care settings using regular phone check-ins and air/smoke measurements. If you’re trying to stop, it may offer structured support and monitoring to help you quit.
Charleston, South CarolinaAges 18 years+ - NCT06751927Recruiting
New ways to help you quit smoking
This study tests new strategies to help people quit smoking. It may be right for you if you smoke at least 10 cigarettes a day and are not already using a quit-smoking medication.
Chicago, IllinoisAges 18–75 - NCT06544811Recruiting
Smokefree Native: Smartphone quit support for American Indians
This trial tests a smartphone-based program to help American Indian adults quit smoking. If you are ready to try quitting and have daily access to a smartphone, you may be able to join for free support.
Minneapolis, MinnesotaAges 18 years+ - NCT06236347Enrolling by invitation
Rural COPD study using e-visits for smokers
This study tests whether online e-visits can help rural smokers without COPD quit smoking. It uses smartphone tools and mailed devices to track progress remotely.
Charleston, South CarolinaAges 40 years+ - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT05660525Recruiting
Helping rural smokers quit with pharmacist support and nicotine replacement
This study tests a smoking-cessation program delivered through community pharmacies in rural Appalachia. It may help people quit smoking using nicotine replacement (patch or lozenges) plus support from pharmacists.
Charlottesville, VirginiaAges 18 years+ - NCT05337722Recruiting
Phone app with peer support to help pregnant people quit smoking
This trial tests a smartphone app that aims to help pregnant people stop smoking, using support from peers (other people going through it). If you smoke regularly and can use an Android phone, the app may provide helpful quitting guidance and encouragement.
Cluj-Napoca, ClujAges 18 years+ - NCT05627674Enrolling by invitation
Help improve lung cancer screening and quitting support uptake
This study tests a “precision” approach to help people who are newly eligible for lung cancer screening actually get screened and start smoking-cessation treatment. If it works, it could make screening and quitting help easier to access and more engaging.
St Louis, MissouriAges 18 years+ - NCT07049757Recruiting
Healthy Family Project: Reducing tobacco smoke in Chinese American homes
This study helps Chinese American families reduce tobacco use and secondhand smoke exposure. Smokers, family members, and community health workers are all welcome.
San Francisco, CaliforniaAges 18 years+ - NCT06474299RecruitingPhase 4
Quit Smoking and Vaping With Patches and Pills
This study tests whether a combination of a nicotine patch plus a medication called varenicline can help people who both smoke and vape quit both. You'll get free medication and support to help you stop.
Madison, WisconsinAges 21 years+ - NCT06926608Recruiting
Helping Latinos quit smoking and get active
This trial is for Hispanic or Latino adults who smoke and want to quit. It tests a program that combines text messages and a wearable activity tracker to help you quit smoking and become more physically active.
Rochester, New YorkAges 18 years+ - NCT06853483Enrolling by invitation
School program to help parents quit smoking
This trial tests if a school-based program can help parents stop smoking. If you are a parent who smokes at least one cigarette a day and your child is in primary 4 (4th grade), this program may offer support to help you quit.
Wuhan, HubeiAges Any age - NCT07166120Recruiting
A tailored approach to help cancer patients quit smoking
This trial tests a personalized treatment plan to help people with cancer stop smoking. Researchers will see if matching you with the right medication (like the nicotine patch, lozenge, or varenicline) can improve your chances of quitting and living longer.
St Louis, MissouriAges 18–89 - NCT06693700Recruiting
Using an air quality monitor to help make your home smoke-free
This study tests whether an indoor air quality monitor can help people keep their homes smoke-free. It is for MSK patients who currently smoke and want to reduce smoke exposure indoors.
Basking Ridge, New JerseyAges 18 years+ - NCT06556433Recruiting
Smoking Cessation Trial with Family Support and Financial Incentives
This study tests whether offering financial rewards to both you and a family member can help you quit smoking. You will be asked to quit smoking, and both you and your nominated family member can earn payments for meeting certain milestones.
Anchorage, AlaskaAges 18 years+ - NCT07602699RecruitingPhase 2
Tirzepatide to Help People Quit Smoking
This study tests whether tirzepatide, a medication that helps with weight and blood sugar, can also help people quit smoking. You'd receive the medication plus standard quitting support (nicotine patches or gum and a quit-smoking app) over several months.
Los Angeles, CaliforniaAges 21–65 - NCT04725617Recruiting
Smoking-quit program for people with HIV and sleep issues
This study tests a wellness-based smoking-cessation program (including the stop-smoking medicine varenicline) for people living with HIV who want to quit. It aims to help you reduce or stop smoking while monitoring safety, sleep, and mental health during the program.
Phoenix, ArizonaAges 18–75 - NCT05224154Recruiting
Help to quit smoking using a smartphone program
This study tests a smartphone-based program to help people quit smoking. It may help if you want to stop and are comfortable using a phone and speaking/read English.
Glassboro, New JerseyAges 18 years+ - NCT05493254Recruiting
Telehealth help to quit smoking in primary care visits
This study tests a phone/video-based program to help people quit smoking through primary care. It may help you get support and track your progress remotely.
Charleston, South CarolinaAges 18 years+
Hear when a new Smoking Cessation trial opens
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Smoking Cessation trials by city
Studies with a site in or near these metro areas.
Smoking Cessation trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 159 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.