Clinical trials
Cigarette Smoking clinical trials
Below are recruiting cigarette smoking clinical trials, each written for real people, not researchers. We’re tracking 81 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05660525Recruiting
Helping rural smokers quit with pharmacist support and nicotine replacement
This study tests a smoking-cessation program delivered through community pharmacies in rural Appalachia. It may help people quit smoking using nicotine replacement (patch or lozenges) plus support from pharmacists.
Charlottesville, VirginiaAges 18 years+ - NCT03721822RecruitingPhase 1
Imaging how smoking affects lung inflammation in adults
This Phase 1 study uses special lung imaging to measure inflammation after different types of smoking or vaping. It looks at differences between people and may help researchers understand how smoking-related lung irritation develops.
Philadelphia, PennsylvaniaAges 18–45 - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06693700Recruiting
Using an air quality monitor to help make your home smoke-free
This study tests whether an indoor air quality monitor can help people keep their homes smoke-free. It is for MSK patients who currently smoke and want to reduce smoke exposure indoors.
Basking Ridge, New JerseyAges 18 years+ - NCT07580040Recruiting
How Smoking Affects the Eyes in the Short Term
This study measures how cigarette smoking immediately affects your eyes' health and structure. Researchers compare current smokers to people who have never smoked to understand if smoking causes quick changes to the eye's surface and shape.
IstanbulAges 18–60 - NCT06945120Recruiting
Lung Health Program for Chinese and Korean Smokers
This study is testing a program to help Chinese and Korean adults who smoke to improve their lung health. You may be able to join if you are a current smoker, speak Korean, Mandarin, or English, and live in the U.S.
Boston, MassachusettsAges 18–100 - NCT06816459RecruitingEarly Phase 1
Scent tests to find flavors in menthol cigarettes
This study tests if adult menthol cigarette smokers can identify different flavors by smell. You will complete a simple smell test and then try different cigarettes to see if you can tell flavors apart.
Buffalo, New YorkAges 21–55 - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking
This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.
Columbus, OhioAges 21 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT06535867Recruiting
Comparing phone-based vs. in-person mouth cancer screening in rural India
This study compares two ways to find early signs of mouth cancer or conditions that could lead to cancer. One method uses a simple phone-based health check, and the other uses standard in-person screening. People in rural areas of Varanasi who are at risk—such as those who use tobacco or have mouth sores—may be able to join.
New York, New YorkAges 18 years+ - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT07553962Recruiting
How couples support each other when quitting smoking
This study looks at how couples who both smoke can help each other quit. Researchers want to understand the ways partners support one another during a smoking cessation attempt, which may help improve quit success rates.
Denver, ColoradoAges 18 years+ - NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+ - NCT06373679Recruiting
Switch or Quit: A study for smokers who want to quit
This study helps adults 21 and older who have tried to quit smoking with a stop-smoking medication. You may be able to join if you want to try quitting again or want to reduce harm from tobacco.
Charleston, South CarolinaAges 21 years+ - NCT07348679Recruiting
Cigarette filter study for adult smokers
This study tests how different cigarette filters work in smokers who are not trying to quit. You must smoke at least 5 non-menthol cigarettes daily and not use Natural American Spirit or menthol brands.
New Brunswick, New JerseyAges 21 years+ - NCT06357767Recruiting
Quit Smoking Program for American Indian Women
This study tests a program to help American Indian women who smoke and have recently experienced abuse from a partner quit smoking. It focuses on women in the Rapid City area and offers support to quit.
Rapid City, South DakotaAges 18 years+ - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06020248Recruiting
How Skin Color Affects Thirdhand Smoke Exposure
This study looks at how thirdhand cigarette smoke (the residue left on surfaces after smoking) gets absorbed into skin, and whether skin color affects this absorption. Researchers want to understand health risks from exposure to smoke residue in homes and public spaces.
San Francisco, CaliforniaAges 18–50 - NCT07129590Recruiting
Trauma-informed care to help pregnant people quit smoking
This study tests whether a trauma-informed care approach can help pregnant people who have experienced trauma to quit smoking. The study involves clinicians and patients working together to improve smoking cessation support.
San Francisco, CaliforniaAges 18 years+ - NCT06213532Recruiting
Connect to lung care study for smokers
This study, called CONNECTing to LungCare, helps current smokers who get their primary care at UCSF clinics learn about lung cancer screening. The goal is to make it easier for people to get screened and to support smokers in their health journey.
San Francisco, CaliforniaAges 18 years+ - NCT06145763Recruiting
Quit smoking with a digital program for American Indian and Alaska Native adults
This study tests two smartphone apps to help American Indian and Alaska Native adults quit smoking. You will be randomly assigned to one of the apps and complete short surveys to see which works better.
Seattle, WashingtonAges 18 years+ - NCT04449458Recruiting
Online group program to help you quit smoking
This trial tests an online, group-based smoking-cessation program using nicotine replacement therapy (NRT) to help you quit smoking. It may help by combining stop-smoking support with internet-based group sessions you can join from home.
Tampa, FloridaAges 18 years+ - NCT07625956Enrolling by invitationPhase 4
Nicotine Pouches as a Smoking Substitute Study
This study tests whether nicotine pouches (small pouches you place in your mouth) can help smokers quit or reduce combustible cigarettes. You'll use the pouches as a substitute and attend visits in Charleston, SC to see if this approach works better with new support strategies.
Charleston, South CarolinaAges 21 years+
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Cigarette Smoking trials by city
Studies with a site in or near these metro areas.
Cigarette Smoking trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cigarette smoking?
- Yes. Clin2 currently lists 81 recruiting cigarette smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cigarette smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cigarette smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.