Clinical trials
Tobacco Smoking clinical trials
Below are recruiting tobacco smoking clinical trials, each written for real people, not researchers. We’re tracking 113 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05846841Recruiting
Personalized quit-smoking support in primary care
This study tests a personalized tobacco (smoking) treatment plan delivered in primary care to help reduce cravings and smoking. It may help you quit or smoke less using options like nicotine patches/lozenges or varenicline, chosen to fit your needs.
St Louis, MissouriAges 18 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05896033Recruiting
Study how menthol cigarette rules affect current menthol smokers
This study looks at how changes in menthol cigarette and e-cigarette rules may affect people who currently smoke menthol cigarettes. You may be asked to complete phone-based reports (like a diary) about your smoking patterns.
Charleston, South CarolinaAges 21 years+ - NCT05555069Recruiting
Menthol-flavored vaping study for adult menthol cigarette smokers
This study looks at how menthol flavoring may affect whether adult menthol cigarette smokers switch to e-cigarettes. You may be asked to switch and use e-cigarettes over a set period, while researchers track your smoking behavior.
Kansas City, MissouriAges 21 years+ - NCT07102082Recruiting
Smokeless tobacco product claims study for Western New York smokers
This study looks at how people view a smokeless tobacco product that claims to be less harmful than cigarettes. If you smoke daily and are open to trying a smokeless tobacco product, you may be able to help by taking an online survey.
Buffalo, New YorkAges 21 years+ - NCT05415761Recruiting
Mobile phone support to help you quit smoking in clinic
This study tests different texting/app-based ways to help people quit smoking, especially those who may have less access to care. You may be assigned to one approach and get support through your phone.
Gainesville, FloridaAges 21 years+ - NCT05019495Recruiting
Study to improve quit-smoking support for people with HIV
This trial tests ways to deliver tobacco-quit treatment more effectively for people living with HIV. You may help researchers compare different quit-support approaches to see what works best.
Charleston, South CarolinaAges 21 years+ - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06432985Recruiting
Smoking cessation coaching for veterans with cancer
This study tests a counseling program to help veterans who smoke quit smoking, especially those undergoing cancer treatment or lung cancer screening. It may improve health outcomes during cancer care.
San Francisco, CaliforniaAges 18 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT06876831Recruiting
Lung cancer screening for current and recent smokers
This study aims to create a program to help people get screened for lung cancer while they are in the hospital. It is for people who are at higher risk due to their age and smoking history.
New York, New YorkAges 50–80 - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07439471Recruiting
Study on tobacco and cannabis co-use in young adults
This study looks at why and how young adults use both tobacco and cannabis together. It may help understand patterns of use and improve future health programs.
Buffalo, New YorkAges 18–30 - NCT05814055RecruitingPhase 2
Kava to help quit smoking by easing stress and sleep issues
This Phase 2 study tests whether kava can help people quit smoking, especially by reducing stress and improving sleep during tobacco abstinence. You may be offered kava as part of a quitting support plan and monitored for safety and progress.
Gainesville, FloridaAges 21–75 - NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+
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Common questions
- Are there clinical trials for tobacco smoking?
- Yes. Clin2 currently lists 113 recruiting tobacco smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.