Clinical trials
Tobacco Smoking clinical trials
Below are recruiting tobacco smoking clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05679349Recruiting
Help your clinic improve lung cancer screening for smokers
This study helps primary care clinics reach people who have a long smoking history so they can get lung cancer screening at the right time. It may help you (and others) get reminders and outreach to make screening easier to schedule.
Philadelphia, PennsylvaniaAges 50–77 - NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking
This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.
Columbus, OhioAges 21 years+ - NCT04949464Recruiting
Smoking quit coaching plus lung scans for people with HIV
This study tests a behavior-change program to help people with HIV quit smoking, along with routine low-dose lung CT scans to find warning signs early. It’s a feasibility study, meaning the main goal is to see if the approach is practical and acceptable, and if people can follow through.
La Jolla, CaliforniaAges 45–80 - NCT05672914Recruiting
Help quitting smoking after a psychiatric hospital stay
This study tests a program meant to help people stop smoking after they leave a psychiatric hospital. It may help you stay smoke-free longer by offering structured support during a high-risk time.
Austin, TexasAges 18 years+ - NCT03948893Recruiting
Behavior program to help you quit nicotine
This study tests a structured counseling/behavior treatment to help people who smoke become nicotine-free. If you’re interested in quitting, you may be asked to complete questionnaires and follow a quit plan as part of the research.
Columbia, MissouriAges 18 years+ - NCT06988371Enrolling by invitation
Study on smoking habits in a simulated tobacco marketplace
This study looks at how people who smoke occasionally or daily choose and use cigarettes in a simulated online marketplace. It may help researchers understand buying and smoking behaviors better.
Lexington, KentuckyAges 18 years+ - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT05121051RecruitingPhase 2
Broccoli sprout extract to reduce tobacco cancer-causing chemicals
This Phase 2 study tests whether broccoli sprout extract (Avmacol ES) can reduce cancer-causing substances linked to heavy smoking. It’s for adults who smoke heavily and may help lower harmful tobacco-related chemical effects in the body.
Tucson, ArizonaAges 18 years+ - NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT05846841Recruiting
Personalized quit-smoking support in primary care
This study tests a personalized tobacco (smoking) treatment plan delivered in primary care to help reduce cravings and smoking. It may help you quit or smoke less using options like nicotine patches/lozenges or varenicline, chosen to fit your needs.
St Louis, MissouriAges 18 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05896033Recruiting
Study how menthol cigarette rules affect current menthol smokers
This study looks at how changes in menthol cigarette and e-cigarette rules may affect people who currently smoke menthol cigarettes. You may be asked to complete phone-based reports (like a diary) about your smoking patterns.
Charleston, South CarolinaAges 21 years+ - NCT05555069Recruiting
Menthol-flavored vaping study for adult menthol cigarette smokers
This study looks at how menthol flavoring may affect whether adult menthol cigarette smokers switch to e-cigarettes. You may be asked to switch and use e-cigarettes over a set period, while researchers track your smoking behavior.
Kansas City, MissouriAges 21 years+ - NCT05415761Recruiting
Mobile phone support to help you quit smoking in clinic
This study tests different texting/app-based ways to help people quit smoking, especially those who may have less access to care. You may be assigned to one approach and get support through your phone.
Gainesville, FloridaAges 21 years+ - NCT05019495Recruiting
Study to improve quit-smoking support for people with HIV
This trial tests ways to deliver tobacco-quit treatment more effectively for people living with HIV. You may help researchers compare different quit-support approaches to see what works best.
Charleston, South CarolinaAges 21 years+ - NCT07102082Recruiting
Smokeless tobacco product claims study for Western New York smokers
This study looks at how people view a smokeless tobacco product that claims to be less harmful than cigarettes. If you smoke daily and are open to trying a smokeless tobacco product, you may be able to help by taking an online survey.
Buffalo, New YorkAges 21 years+ - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06432985Recruiting
Smoking Cessation Program for Veterans with Cancer
This study tests a video-based program to help Veterans who smoke and are being treated for cancer or lung cancer screening to quit. If you're a VA patient in San Francisco and currently smoke, you may be able to join.
San Francisco, CaliforniaAges 18 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT06876831Recruiting
Lung cancer screening for current and recent smokers
This study aims to create a program to help people get screened for lung cancer while they are in the hospital. It is for people who are at higher risk due to their age and smoking history.
New York, New YorkAges 50–80
Hear when a new Tobacco Smoking trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for tobacco smoking?
- Yes. Clin2 currently lists 125 recruiting tobacco smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.