Clinical trials
Tobacco Use clinical trials
Below are recruiting tobacco use clinical trials, each written for real people, not researchers. We’re tracking 97 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05572671Recruiting
Study brain scans to predict near-term smoking relapse risk
This study uses MRI brain scans and smoking measurements to understand what may predict when someone is about to smoke again. If you qualify, you’ll be asked to avoid nicotine for 12 hours before a lab visit and complete MRI safety screening.
University Park, PennsylvaniaAges 21–65 - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05415761Recruiting
Mobile phone support to help you quit smoking in clinic
This study tests different texting/app-based ways to help people quit smoking, especially those who may have less access to care. You may be assigned to one approach and get support through your phone.
Gainesville, FloridaAges 21 years+ - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT04722835Recruiting
Study lung immune cells in people at risk for COPD
This study looks at different lung immune cell patterns and how they work in smokers who are not yet diagnosed with COPD or asthma. It may help researchers understand why some people are more likely to develop COPD, which could guide future prevention or early treatments.
San Francisco, CaliforniaAges 40–75 - NCT04595422Recruiting
Train quitline staff to reach smokers about lung screening
This trial tests an educational approach delivered through tobacco quitlines to encourage eligible smokers to learn about lung cancer screening. It may help people who have a heavy smoking history get the right information and next steps.
Houston, TexasAges 18 years+ - NCT04297592Enrolling by invitationPhase 4
Antibiotics to prevent infection after hip or knee replacement
This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.
Iowa City, IowaAges 18–99 - NCT07441603Recruiting
Lifestyle support program for hospital patients
This trial tests a proactive lifestyle program for patients admitted to the hospital. It aims to help you improve your health habits during your stay.
GreifswaldAges 18–64 - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07439471Recruiting
Study on tobacco and cannabis co-use in young adults
This study looks at why and how young adults use both tobacco and cannabis together. It may help understand patterns of use and improve future health programs.
Buffalo, New YorkAges 18–30 - NCT07202039Recruiting
E-Cigarettes for Smokers on Buprenorphine
This study tests whether switching to electronic cigarettes can help reduce harm for people with opioid use disorder who are on buprenorphine and smoke daily. The goal is to see if e-cigarettes are a safer option than continuing to smoke regular cigarettes.
Greenville, South CarolinaAges 21 years+ - NCT06787937Recruiting
Study on reducing nicotine in cigarettes
This study tests cigarettes that have less nicotine to see how people react to them. You may be able to join if you are a regular adult smoker interested in trying reduced-nicotine cigarettes.
Atlanta, GeorgiaAges 21 years+ - NCT07039175RecruitingPhase 3
Helping veterans with chronic disease change smoking or drinking habits
This study tests a program to help veterans with diabetes, heart disease, or related conditions who are thinking about cutting back on smoking or alcohol. The goal is to see if the program can motivate positive changes in these habits.
Buffalo, New YorkAges 18 years+ - NCT06965153Recruiting
Peer coaching to help people with opioid use disorder quit smoking
This trial tests whether having a peer recovery coach can help people with opioid use disorder quit or reduce smoking. If you're already on medication for opioid use disorder and want to work on your smoking, this program might offer extra support.
Boston, MassachusettsAges 18 years+ - NCT05863923Enrolling by invitation
Text message program to help people with HIV quit smoking
This study tests a texting program that sends messages to help people living with HIV who smoke quit smoking. It may help you reduce tobacco use using regular, motivational text messages.
Worcester, MassachusettsAges 18 years+ - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+ - NCT06395415Recruiting
Mobile health program for young adult e-cigarette users
This study tests a mobile health program to help young adults ages 18–26 who use e-cigarettes regularly to reduce or quit. It uses text messages to support you, and you'll need to be interested in changing your vaping habits.
Chicago, IllinoisAges 18–26 - NCT05338801Recruiting
Study menthol effects in e-cigarette users
This study tests how menthol in e-cigarettes affects addiction-related feelings and exposure. You may be asked to visit a lab and temporarily stop vaping before each session.
Miami, FloridaAges 21–35 - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+ - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65
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Common questions
- Are there clinical trials for tobacco use?
- Yes. Clin2 currently lists 97 recruiting tobacco use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.