Clinical trials
Tobacco Use clinical trials
Below are recruiting tobacco use clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06582888RecruitingEarly Phase 1
VR attention test for smoking cravings
This study tests whether a virtual reality (VR) program can measure how your brain pays attention to smoking cues. It also involves taking a medication called varenicline (Chantix) to see if it reduces cravings. You may be eligible if you are a daily smoker, have been smoking for at least 3 years, and are not ready to quit in the next month.
San Diego, CaliforniaAges 22 years+ - NCT06614504RecruitingPhase 2
Nicotine control for dual e-cigarette and cigarette users
This study is testing how to help people who both smoke cigarettes and use e-cigarettes. It looks at ways to control nicotine use to help you quit or cut back.
Providence, Rhode IslandAges 21 years+ - NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65 - NCT04297592Enrolling by invitationPhase 4
Antibiotics to prevent infection after hip or knee replacement
This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.
Iowa City, IowaAges 18–99 - NCT06746623Recruiting
Non-endoscopic screening for Barrett's in veterans without reflux
This trial tests a new, non-endoscopic screening method for Barrett's esophagus (a condition that can lead to cancer) in veterans who do not have chronic acid reflux. It aims to find early signs of the condition using a simple swallowable device, potentially avoiding the need for a traditional endoscopy.
Cleveland, OhioAges 40–85 - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT06930547Recruiting
Smoking cessation education for recovery
This study tests whether education classes can help people who are in recovery from mental health issues quit smoking. It is for people registered with a Community Mental Health Center who smoke daily.
Erzurum, ErzurumAges 18 years+ - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT07108166Recruiting
COPD and Chronic Bronchitis: Switching from Cigarettes to Heat-Not-Burn Device
This study tests whether switching from regular cigarettes to a heated tobacco device (a product that heats rather than burns tobacco) can improve symptoms and lung function in people with moderate COPD and chronic bronchitis. Participants will be randomly assigned to either switch to the heated device or continue smoking cigarettes.
Clearwater, FloridaAges 40 years+ - NCT07292883RecruitingPhase 2
Accelerated TMS for smoking cessation
This trial tests whether a rapid form of brain stimulation (TMS) can help people stop smoking. It is designed for adults who are ready to quit within the next month.
Penetanguishene, OntarioAges 18 years+ - NCT07447362Recruiting
Managing heart health risks in adults
This study checks if a program to manage heart health risks works better than usual care. If you have a risk factor like high blood pressure, diabetes, or smoking, you may qualify.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07466875Recruiting
Ear stimulation for nicotine withdrawal in psychiatric patients
This trial tests whether gentle electrical stimulation on the ear can help relieve nicotine withdrawal symptoms for smokers who are in a psychiatric hospital and must stop smoking. It is added on top of standard nicotine replacement therapy.
Nantou CityAges 18–65 - NCT07576595Recruiting
Lung Cancer Screening and Quit-Smoking Support for African Americans
This study helps African American smokers get lung cancer screening and receive support to quit smoking. Researchers will provide guidance and resources tailored to help you stop smoking and catch lung disease early if needed.
New Orleans, LouisianaAges 50–80 - NCT05992272Recruiting
How cues affect drinking and smoking habits
This study looks at how certain cues (like seeing a drink or a cigarette) trigger cravings and behavior in people who drink alcohol or smoke. Understanding this may help improve addiction treatments.
BerlinAges 16–65 - NCT07441603Recruiting
Lifestyle support program for hospital patients
This trial tests a proactive lifestyle program for patients admitted to the hospital. It aims to help you improve your health habits during your stay.
GreifswaldAges 18–64 - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07439471Recruiting
Study on tobacco and cannabis co-use in young adults
This study looks at why and how young adults use both tobacco and cannabis together. It may help understand patterns of use and improve future health programs.
Buffalo, New YorkAges 18–30 - NCT06787937Recruiting
Study on reducing nicotine in cigarettes
This study tests cigarettes that have less nicotine to see how people react to them. You may be able to join if you are a regular adult smoker interested in trying reduced-nicotine cigarettes.
Atlanta, GeorgiaAges 21 years+ - NCT07202039Recruiting
E-Cigarettes for Smokers on Buprenorphine
This study tests whether switching to electronic cigarettes can help reduce harm for people with opioid use disorder who are on buprenorphine and smoke daily. The goal is to see if e-cigarettes are a safer option than continuing to smoke regular cigarettes.
Greenville, South CarolinaAges 21 years+ - NCT07039175RecruitingPhase 3
Helping veterans with chronic disease change smoking or drinking habits
This study tests a program to help veterans with diabetes, heart disease, or related conditions who are thinking about cutting back on smoking or alcohol. The goal is to see if the program can motivate positive changes in these habits.
Buffalo, New YorkAges 18 years+ - NCT05863923Enrolling by invitation
Text message program to help people with HIV quit smoking
This study tests a texting program that sends messages to help people living with HIV who smoke quit smoking. It may help you reduce tobacco use using regular, motivational text messages.
Worcester, MassachusettsAges 18 years+ - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+
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Common questions
- Are there clinical trials for tobacco use?
- Yes. Clin2 currently lists 103 recruiting tobacco use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.