Clinical trials
Treatment Resistant Depression clinical trials
Below are recruiting treatment resistant depression clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT07777575RecruitingPhase 4
Exercise and medication for weight loss while preserving muscle
This study tests whether a type 2 diabetes medication (tirzepatide) combined with a supervised resistance training (weight lifting) program helps prevent muscle loss while losing weight. You will either receive the medication or a placebo, and all participants will follow a diet and exercise plan.
München, BavariaAges 18–60 - NCT05869682RecruitingPhase 2
Bright light therapy for fatigue and depression in prostate cancer
This Phase 2 study tests whether a “bright white light” intervention can reduce cancer-related fatigue and depression in people with advanced prostate cancer receiving hormone-based treatment. If it works, it could improve day-to-day well-being while you’re on standard cancer therapies.
Duarte, CaliforniaAges 60 years+ - NCT06324422Recruiting
Exercise for Parkinson's fatigue
This trial tests if a structured exercise program can reduce fatigue in people with Parkinson's disease. It may help you feel less tired and improve daily function.
Aarhus, Central JutlandAges 40 years+ - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60
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Common questions
- Are there clinical trials for treatment resistant depression?
- Yes. Clin2 currently lists 125 recruiting treatment resistant depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment resistant depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment resistant depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.