Clinical trials
Treatment-resistant Bipolar Depression clinical trials
Below are recruiting treatment-resistant bipolar depression clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07876908Recruiting
Magnetic brain therapy for older adults with hard-to-treat depression
This trial tests a new intensive magnetic brain treatment (SAINT) for older adults whose depression has not improved with standard treatments. It aims to see if this treatment can also help with memory concerns, which are common in this group.
Costa Mesa, CaliforniaAges 65 years+ - NCT07843927RecruitingPhase 3
Adding DHEA hormone to antidepressants for difficult depression
This study tests whether adding a natural hormone called DHEA to your regular antidepressant can help improve depression symptoms. DHEA is a supplement that may boost the effectiveness of standard antidepressants for people with hard-to-treat depression.
Berlin, State of BerlinAges 18–75 - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT06378229RecruitingPhase 2
Psilocybin for hospitalized treatment-resistant depression
This trial tests whether a single dose of psilocybin can help hospitalized patients with tough-to-treat depression. It focuses on people who haven't improved with standard antidepressants and need a new option.
Ghent, Oost-VlaanderenAges 18 years+ - NCT07758010Recruiting
Brain stimulation for treatment-resistant depression
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
Belmont, MassachusettsAges 18 years+ - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT07745374Recruiting
Deep brain stimulation for bipolar depression
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, is safe and feasible for people with bipolar depression that hasn't improved with other treatments. It may offer a new option for those who have exhausted standard therapies.
New York, New YorkAges 22–70 - NCT07696871RecruitingPhase 1/Phase 2
Cannabidiol oil for treatment-resistant depression
This trial tests if cannabidiol (CBD) oil can help people with major depression that has not improved with standard antidepressants. You will take CBD oil or a placebo while continuing your current antidepressant treatment to see if it improves your symptoms.
Tubarão, Santa CatarinaAges 18–69 - NCT07673913Recruiting
Blood markers and brain stimulation for hard-to-treat depression
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
Ankara, AnkaraAges 18–55 - NCT07680140RecruitingPhase 4
Using biomarkers to choose depression treatment
This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.
New York, New YorkAges 18–70 - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Birmingham, AlabamaAges 18–75 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT07369102RecruitingPhase 4
Esketamine with or without talk therapy for tough depression
This trial tests if adding a type of talk therapy called integration therapy helps esketamine work better for people with depression that hasn't improved with other treatments. You'll receive esketamine, and some people also get guided sessions to reflect on their experiences.
San JuanAges 21–65 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Birmingham, AlabamaAges 18–65 - NCT07226232RecruitingPhase 3
Psilocybin for veterans with treatment-resistant depression
This study tests whether psilocybin (a psychedelic substance) can help veterans with depression that hasn't improved with standard treatments.
Birmingham, AlabamaAges 18–75 - NCT07217223Recruiting
Home-based brain stimulation for treatment-resistant depression
This study tests whether a gentle brain stimulation technique called tDCS can help people with depression that hasn't improved with medication. It can be done at home using a special headset and an internet connection.
San Diego, CaliforniaAges 18–85 - NCT07210112RecruitingPhase 2
Psilocybin and Trazodone for tough-to-treat depression
This trial tests if taking psilocybin (a psychedelic drug) with trazodone (an antidepressant) can help people whose depression hasn't improved with at least two standard antidepressants. If you have treatment-resistant depression, this study might be an option.
ParisAges 18 years+ - NCT07211438RecruitingPhase 2
Psilocybin with Monitors for Treatment-Resistant Depression
This study tests whether trained monitors improve the safety and outcomes of psilocybin therapy for people with depression that hasn't responded to other treatments. Participants will receive psilocybin in a supervised setting and will need to temporarily stop other psychiatric medications.
Toronto, OntarioAges 18–70 - NCT07184619RecruitingPhase 3
Evenamide for hard-to-treat schizophrenia (add-on study)
This trial tests a new medication, evenamide, added to your current antipsychotic treatment. It looks to see if it can help people whose schizophrenia has not responded well to standard therapies.
Los Angeles, CaliforniaAges 18 years+ - NCT07183748RecruitingPhase 2
Psilocybin microdosing plus therapy for hard-to-treat depression
This trial tests whether taking very small, repeated doses of psilocybin (a substance found in magic mushrooms) along with talk therapy can help people with depression that hasn't gotten better with other treatments. You'll need to stop your current depression medications and avoid drugs or alcohol for the study period.
BeershebaAges 18–65 - NCT07166289Recruiting
Ultrasound treatment for tough depression
This study uses focused ultrasound to stimulate brain circuits in people with treatment-resistant depression. It aims to see if this can help when other treatments haven't worked.
Tulsa, OklahomaAges 18–65 - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70
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Common questions
- Are there clinical trials for treatment-resistant bipolar depression?
- Yes. Clin2 currently lists 47 recruiting treatment-resistant bipolar depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment-resistant bipolar depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment-resistant bipolar depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.