Treatment
Buprenorphine clinical trials
We’re tracking 51 recruiting studies that include Buprenorphine, each written for real people, not researchers, below.
Recruiting studies
- NCT06306443RecruitingPhase 3
Buprenorphine treatment for people leaving jail
This trial offers buprenorphine (a medication for opioid use disorder) to people in jail who are soon to be released. It helps you start treatment while incarcerated and continue it after you return to the community, aiming to reduce overdose and improve recovery.
Baltimore, MarylandAges 18 years+ - NCT06316830RecruitingPhase 2/Phase 3
Finding the best buprenorphine dose for opioid use disorder
This trial tests different doses of buprenorphine to find the safest and most effective one for treating opioid use disorder and preventing overdose. It is for people who have used fentanyl and are starting or continuing buprenorphine treatment.
Providence, Rhode IslandAges 18 years+ - NCT06051890RecruitingPhase 4
Assessing switching to long-acting buprenorphine injection in jail
This study tests whether switching from daily buprenorphine/naloxone (Suboxone) to a long-acting injectable buprenorphine (XRB) is safe and effective for men who are unsentenced and in jail for at least 4 days. It aims to see if the injection can help continue treatment without needing daily medication.
Boston, MassachusettsAges Any age - NCT05778591RecruitingPhase 2
Low-dose buprenorphine to improve social drive in schizophrenia
This study tests whether low-dose buprenorphine can improve social motivation in people with schizophrenia. It compares social motivation changes while keeping participants stable on treatment and avoiding certain medicines and substances.
Los Angeles, CaliforniaAges 18–60 - NCT05450718RecruitingPhase 4
Low-dose buprenorphine start for opioid use disorder
This trial tests whether starting buprenorphine using a low-dose plan is a safe and workable way to treat opioid use disorder. You may be able to join if you are 18+, have opioid use disorder, and can follow the study medication and visits.
The Bronx, New YorkAges 18 years+ - NCT03923374Recruiting
Study of buprenorphine for opioid use during pregnancy
This study looks at pregnancy and baby outcomes for people who are pregnant and taking buprenorphine for opioid use disorder. It may help doctors understand what to expect long-term for both parent and child when opioid treatment continues during pregnancy.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05189223Recruiting
Values coaching for veterans starting opioid addiction medicines
This study tests a brief “values-based” coaching/support session to help veterans adjust and stick with early treatment for opioid use disorder. It may help you feel more grounded and supported during the first months after starting medicines like buprenorphine, methadone, or naltrexone.
Bedford, MassachusettsAges 18 years+ - NCT07620171Enrolling by invitation
Peer Support to Help You Stay in Opioid Treatment
This study tests whether talking regularly with someone who has recovered from opioid addiction helps you stay in buprenorphine treatment longer. Buprenorphine is a medication that reduces cravings and withdrawal, and peer support may help you stick with it.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07475728Recruiting
Buprenorphine for Opioid Use Started by Emergency Medical Services
This study looks at offering buprenorphine through emergency medical services (EMS) to people having an opioid emergency. It aims to see if starting treatment in the field helps people get connected to long-term care.
Oakland, CaliforniaAges Any age - NCT07420283RecruitingPhase 2
Study of Brenipatide for opioid use disorder
This trial tests a new medicine called Brenipatide for people with opioid use disorder who are already taking buprenorphine but still occasionally use non-prescribed opioids. It aims to see if the study drug can help reduce opioid use.
Phoenix, ArizonaAges 18–75 - NCT07278518Recruiting
Emergency department decision aid for buprenorphine
This trial is testing a tool to help people in the emergency department decide whether to start buprenorphine (a medication for opioid use disorder). It's for patients who are not already on medication for their condition.
Charleston, South CarolinaAges 18 years+ - NCT07251283Recruiting
Food insecurity and eating in opioid treatment
This study looks at how food insecurity (not having enough to eat) affects eating habits in people taking methadone or buprenorphine for opioid use disorder. The goal is to learn more about food access and help improve support for people in treatment for opioid addiction.
Burlington, VermontAges 18 years+ - NCT07202039Recruiting
E-Cigarettes for Smokers on Buprenorphine
This study tests whether switching to electronic cigarettes can help reduce harm for people with opioid use disorder who are on buprenorphine and smoke daily. The goal is to see if e-cigarettes are a safer option than continuing to smoke regular cigarettes.
Greenville, South CarolinaAges 21 years+ - NCT07169409RecruitingPhase 1
Telehealth for opioid use disorder in vulnerable settings
This trial tests whether a telehealth program can help people with opioid use disorder get and stay on buprenorphine treatment. It aims to make care more accessible for those in vulnerable situations.
Portland, OregonAges 18 years+ - NCT07044466Recruiting
Social functioning study for people in treatment for opioid use
This study looks at how people recovering from opioid use disorder get along with a close friend or family member (called a CSO). It may help improve social support during early treatment.
Charleston, South CarolinaAges 18 years+ - NCT07024498Recruiting
Buprenorphine follow-up after emergency care
This study helps coordinate ongoing care for people who start buprenorphine, a medication for opioid use disorder, while in the emergency department. It aims to connect you with continued treatment to support your recovery.
El Centro, CaliforniaAges 14 years+ - NCT06999811Recruiting
Technology vs. medication monitoring for buprenorphine in pregnancy
This study compares two approaches to help pregnant people stay on buprenorphine (a medication for opioid use disorder): one uses technology to support therapy, and the other uses standard medication monitoring. It aims to see which method works better for keeping you in treatment during pregnancy.
Charleston, South CarolinaAges 18–45 - NCT06642181RecruitingPhase 1
Guanfacine and meditation with buprenorphine for opioid use disorder
This study tests if adding a medication called guanfacine and mindfulness meditation to standard buprenorphine treatment helps people with opioid use disorder. It looks at whether this combination can improve treatment outcomes and reduce opioid use.
Newark, New JerseyAges 18–55 - NCT06651177RecruitingPhase 2
Tirzepatide with buprenorphine for opioid use disorder
This study tests whether adding tirzepatide, a medication used for weight and blood sugar, to buprenorphine treatment helps people with opioid use disorder. It aims to see if the combination improves outcomes compared to buprenorphine alone.
Jacksonville, FloridaAges 18 years+ - NCT06574009RecruitingPhase 4
Better options for chronic cancer pain in veterans
This study tests if switching from long-term opioid painkillers to buprenorphine (a different type of pain medication) can provide better pain relief for veterans who have had cancer but are currently cancer-free. It aims to find a safer and more effective way to manage chronic pain.
Indianapolis, IndianaAges 18–99 - NCT06416020Recruiting
Support for starting addiction treatment in community settings
This study looks at ways to help people who have just started taking buprenorphine for opioid use disorder stick with their treatment. It tests extra support outside of a clinic to help you stay on track and feel better.
Washington D.C., District of ColumbiaAges 16 years+ - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT06067737RecruitingPhase 2
Psilocybin and buprenorphine for opioid use disorder
This study tests whether adding psilocybin (a psychedelic medicine) to buprenorphine (a medication for opioid use disorder) can help people stop using opioids and stay in recovery. It is for people who have already been on buprenorphine but are still using other opioids.
Baltimore, MarylandAges 21–70 - NCT05942313Recruiting
Predicting and preventing problems from opioid use during pregnancy
This study looks at ways to predict and reduce harmful outcomes for pregnant people with opioid use disorder (OUD) and their babies. It focuses on people who are already receiving ongoing medication treatment during pregnancy and will follow them around delivery at a specific hospital.
Pittsburgh, PennsylvaniaAges 18 years+
Common questions
- Are there clinical trials studying Buprenorphine?
- Yes. Clin2 currently lists 51 recruiting studies that include Buprenorphine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Buprenorphine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Buprenorphine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Buprenorphine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.