Treatment
Buprenorphine clinical trials
We’re tracking 50 recruiting studies that include Buprenorphine, each written for real people, not researchers, below.
Recruiting studies
- NCT05988710RecruitingPhase 4
Low-dose buprenorphine for pain in opioid-naive adults
This study tests a low-dose form of buprenorphine (a medicine for pain) placed inside the cheek. It is designed for people who have never taken opioids before, to see how well it works for pain and how likely it is to be misused.
Nashville, TennesseeAges 18–65 - NCT04375033RecruitingPhase 4
Comparing Buprenorphine pill vs injection for opioid use disorder
This study compares two forms of a medication called buprenorphine (one is a pill you take under the tongue, the other is an injection) to see which works better for treating opioid use disorder. If you are eligible, you will receive one of these forms for a year and regular check-ups.
Tuscaloosa, AlabamaAges 18 years+ - NCT07439549RecruitingPhase 4
Quick-start buprenorphine with naloxone for opioid use disorder
This study tests a faster way to start buprenorphine (a medication for opioid use disorder) by using naloxone to briefly trigger mild withdrawal. This could help people get started on treatment more comfortably and quickly.
Vancouver, British ColumbiaAges 19 years+ - NCT05824832RecruitingPhase 4
Buprenorphine, clonidine, and steroid to extend arm nerve block
This study tests whether adding certain medicines (buprenorphine, clonidine, and a steroid) to an arm “nerve block” during shoulder surgery can help the numbness last longer and improve comfort afterward. It is for adults having shoulder arthroscopy and compares how long the nerve block works.
Maywood, IllinoisAges 18 years+ - NCT06880718RecruitingPhase 4
Injectable buprenorphine for opioid use disorder in prison
This study tests whether a once-monthly injection of buprenorphine (called extended-release buprenorphine, or XR-B) works well for people in prison who are already in a medication program for opioid use disorder. It looks at preferences and outcomes in the last months before release.
Cranston, Rhode IslandAges 18 years+ - NCT06726200RecruitingEarly Phase 1
Comparing buprenorphine formulations for fentanyl addiction
This study tests two different forms of buprenorphine (a medication for opioid addiction) to see which works better for people who use fentanyl or other strong synthetic opioids. If you are seeking treatment for opioid use, this trial may help you find the most effective option.
New York, New YorkAges 18–65 - NCT05589181RecruitingPhase 3
High-dose buprenorphine start in the emergency department for fentanyl use
This Phase 3 study tests whether starting a high dose of buprenorphine in the emergency department helps people with opioid use disorder come through withdrawal more safely and effectively. It focuses on people whose urine test shows fentanyl and who are already in withdrawal when they arrive.
Newark, New JerseyAges 18 years+ - NCT03460314Recruiting
Testing buprenorphine absorption around stomach weight-loss surgery
This study checks how well buprenorphine (a medicine used for opioid dependence and pain in some cases) works in the body after gastric bypass or sleeve gastrectomy. It may help doctors better plan dosing and timing around weight-loss surgery.
TrondheimAges 18–70 - NCT07733128Recruiting
Pain relief with buprenorphine patch after lung surgery
This study tests a skin patch that releases buprenorphine, a pain medicine, to control pain after lung surgery. It may help reduce pain and the need for other pain medicines.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07631598Recruiting
Buprenorphine at Needle Exchange Programs to Prevent Overdoses
This study tests whether offering buprenorphine (a medication that reduces cravings and withdrawal) directly at syringe service programs (places where people get clean needles) can help people with opioid addiction stay safe and reduce overdose risk. If you use opioids and visit a syringe service program, this may be an option to explore.
Los Angeles, CaliforniaAges 18 years+ - NCT07485335RecruitingPhase 4
Overdose prevention support after emergency department care
This study tests a package of support services to help people who have had an opioid overdose and are starting buprenorphine in the emergency department. The goal is to keep them safe and reduce the chance of another overdose.
Birmingham, AlabamaAges 19 years+ - NCT05883358Recruiting
Treating kratom withdrawal with clonidine or buprenorphine
This trial studies medicines (clonidine and/or buprenorphine) to help manage kratom dependence and kratom withdrawal symptoms. You may be asked to regularly track withdrawal symptoms in diaries to help the study team monitor safety and response.
Surrey, British ColumbiaAges 20–99 - NCT07430345RecruitingPhase 1/Phase 2
Buprenorphine for pain in older adults with broken bones
This trial tests a low-dose pain medicine called buprenorphine for people 65 and older who come to the emergency room with a broken bone. It aims to find a safe way to manage pain in older adults.
Camden, New JerseyAges 65 years+ - NCT07434427RecruitingPhase 4
Buprenorphine vs. oxycodone for pain after lung surgery
This study compares two common pain medicines given through a patient-controlled pump after lung surgery done with small incisions. The goal is to see which one works better and has fewer side effects.
Zabrze, Silesian VoivodeshipAges 18–75 - NCT07421102RecruitingEarly Phase 1
Mailing buprenorphine after hospital stay
This study tests whether mailing buprenorphine (a medication for opioid use disorder) to patients after they leave the hospital helps them stay on treatment. If you started buprenorphine in the hospital and are heading home to South Carolina, this option might make it easier to continue your recovery.
Charleston, South CarolinaAges 18 years+ - NCT07176351RecruitingPhase 4
Monthly buprenorphine injections from a mobile clinic
This study tests a new way to receive buprenorphine—a once-a-month injection—from a mobile clinic that comes to you. It aims to make treatment more convenient and acceptable for people with opioid use disorder.
New Haven, ConnecticutAges 18 years+ - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT03646058RecruitingPhase 3
Add-on buprenorphine to ease suicidal thoughts in depression
This Phase 3 study tests whether adding buprenorphine to your usual pain-dose medicines can reduce severe suicidal thoughts during a major depressive episode. It may help people who are currently hospitalized or closely followed and have higher scores for both depression severity and suicidal thinking.
Bordeaux, FranceAges 18–65 - NCT06494904RecruitingPhase 3
Standard vs. High Dose Buprenorphine in the ER
This study compares a higher dose of buprenorphine (a medicine that helps stop opioid cravings and withdrawal) to the usual dose, given in the emergency department. It aims to see if the higher dose works better to start treatment for opioid use disorder.
Oakland, CaliforniaAges 18–65 - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06415994Enrolling by invitation
Placental imaging and outcomes in opioid use disorder in pregnancy
This study looks at how the placenta and baby's development may be affected when a mother takes buprenorphine or methadone for opioid use disorder during pregnancy. It aims to find better ways to monitor health and improve outcomes for both mothers and babies.
Indianapolis, IndianaAges 18–100 - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06323824RecruitingPhase 4
Methadone vs. buprenorphine for opioid use disorder treatment
This study compares two medications, methadone and buprenorphine, to see which helps people stay in treatment for opioid use disorder. You may be eligible if you are starting a new treatment episode.
Oakland, CaliforniaAges 18–99 - NCT06316830RecruitingPhase 2/Phase 3
Finding the best buprenorphine dose for opioid use disorder
This trial tests different doses of buprenorphine to find the safest and most effective one for treating opioid use disorder and preventing overdose. It is for people who have used fentanyl and are starting or continuing buprenorphine treatment.
Providence, Rhode IslandAges 18 years+
What Buprenorphine is being studied for
Conditions with recruiting Buprenorphine studies.
Common questions
- Are there clinical trials studying Buprenorphine?
- Yes. Clin2 currently lists 50 recruiting studies that include Buprenorphine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Buprenorphine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Buprenorphine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Buprenorphine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.