Natural history study for severe combined immune deficiency (SCID)
Part of Genetic & congenital, Hormones & metabolism, Immune system & allergy clinical trials.
This study follows children and adults with SCID and related immune disorders to understand how the illness behaves over time. It also helps researchers learn which testing results and genetic types of SCID match different treatment plans.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or your child) have SCID or a related condition that doctors classify as one of the SCID “types” the study studies
- Blood testing shows the T-cell immune part is missing or severely weak (the exact lab cutoffs depend on the SCID type)
- Your doctor plans a specific SCID treatment path (for example, transplant, PEG-ADA replacement medicine, or gene therapy)
- If this is “typical” SCID: either T cells are very low, T-cell function is very low, or T cells came from the mother
- If this is Omenn syndrome or “leaky” SCID: specific lab and symptoms (like rash for Omenn) and maternal cell testing must fit the study’s rules
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a gene therapy that uses base-edited stem cells to treat X-SCID, a genetic immune disorder. It may help improve immune function and reduce infections in patients who still have low immune cells or severe infections despite previous treatments.
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
This early-phase study tests a step-by-step transplant approach: first replacing the lungs, then doing a bone marrow (stem cell) transplant to treat certain immune deficiency diseases. It may help people whose immune problem has led to severe, end-stage lung disease.
This study looks at people with certain immune system weaknesses to see if they are at risk for chronic hepatitis caused by a virus in the gut. Researchers want to understand how the immune system affects this infection.
This study follows babies who had an abnormal newborn screening for severe immune problems. It aims to track their health over time.
This study looks at how the immune system works in people who have abnormal immune function, often shown by unusual or repeated infections or long-lasting inflammation. It may involve tests using blood samples and storage of blood for future research.
Hear when a new Severe Combined Immunodeficiency (SCID) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.